Conserved Protein Domain Family
SPG48
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pfam14764: SPG48 (this model, PSSM-Id:291430 is obsolete and has been replaced by 464303)
AP-5 complex subunit, vesicle trafficking
This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterized by progressive spasticity in the lower limbs.
Links
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Statistics
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PSSM-Id: 291430
Aligned: 33 rows
Threshold Bit Score: 98.424
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0J9X3         34 ASDPILLESVRRVCEMCK---KA--KgpsdE--MVARAFPVMSKLFQRCAAAPTQ----S----Vass--gvLLLTILQF 96   Japanese rice
XP_002978565   26 tADTSVRDAVERLNAMCK---SEgnE----D--LVTRVYPAMTKLFQRCCSSSTQrpstA----L-------VALAILQF 85   Selaginella m...
XP_002281589   29 ASDPNLLPSVRKLYELCK---SE--E----SedLVARVYPQINKIFQRLVASVSQ----S----Rtsn--glLFLAILQF 89   wine grape
XP_003886014 1123 MSDAVGVEAMRILDLVCR---AD--A----E--FVAAVFPTIKRVCERTLAGGGG----L----H-------LFTCVFHF 1176 Neospora cani...
XP_796686     331 LIQACLVEAIETLIVICR---LD--T----S--LVSKLYPSIKQAHTNLAK--KW----P----R-------VQLAILQF 382  purple sea ur...
XP_006352496   32 ASDPSVLNSVKSLCDLCR---SE--K----SedLIARVYPHLNRIFQRCLSSISQ----S----Qtsn--glLLLAILQF 92   potato
XP_002882915   26 ASDPSILQSVKKLHGFCK---LE--K----SddLVARIYPQINKVFHRSVASLSQ----S----EsgtskglLLLAILQF 88   Arabidopsis l...
XP_006826534   25 stDPSLLESVKKLYEMCK---NEnsE----D--LIARVYSHMNKLFQRCIAAMSQ----A----Qtsn--glLHLAILQF 85   Amborella tri...
XP_001753717   32 adDTTVLRAVKNLHRLCAkgeQN--D----D--LVGRVYPHLVKIFNRCSASLLS----Q----Kast--glLLLAILQF 93   Physcomitrell...
XP_004996515  460 LRQAVAKQAIDTLATLAG---VH--P----E--VVPAAKSYIDRLLARFASIPQK----AlyepH-------LLLSLVSF 517  Salpingoeca r...

Q0J9X3         97 FLDFGE--AVLHDADGSLRTFFRSCLSREFADPIVAERTLEFLIANKTKILSSfPTLIPQFFPLLLK 161  Japanese rice
XP_002978565   86 FLDHGE--TVLHDADPSLRAFFRSCLVKQYADPAVAAATVAFLNHNKMKLLLSySSVLPQFFPLLLK 150  Selaginella moellendorffii
XP_002281589   90 FLDFGE--IVLHDADPSLRTFFRSCLSREFADPVVAKATLDFLIWNKKKILTSfptllpqffplllk 154  wine grape
XP_003886014 1177 YLHHHP--HQLLSLDSFVQQYVTH-LGLHYRSVLLSMNALTFLNNNLQALVVK-TNIFTRYFPVIFK 1239 Neospora caninum Liverpool
XP_796686     383 FLDYSEalHVVFKPEETIADLFGEVITRYMHDDTVTFDTVTFLLTNLQQLCLE-TELLEKYSPSILR 448  purple sea urchin
XP_006352496   93 FLDFGD--VVLHDADPNLRTFFKSCLSREFADPVVAEATLDFLNANKKKFSSSfptllpqffplllk 157  potato
XP_002882915   89 FLDFGD--MVLHDADPSLRTFFRSCLSREFSDSAVAEATCEFLVANQRKLLAS--------FPNllp 145  Arabidopsis lyrata subsp. ...
XP_006826534   86 FLDFGE--VVLHDANSSLRAFFRSCLSRQFAAPVVAESTLNFLFLNKTRFLNSfpsllpqffplllk 150  Amborella trichopoda
XP_001753717   94 FLDFGE--IVLHDSDPSLRTFFRSCLSRQYADATVAAATLKFLNQNKAKLVVAhpallpqyyplllk 158  Physcomitrella patens
XP_004996515  518 FVAYGE--HIAFDLHALFDSFFESVLGVRFADPRLCLDTISMLMEHRTALL-N-TRLFPVHFPTILR 580  Salpingoeca rosetta
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