3LFM


Conserved Protein Domain Family
FTO_CTD

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pfam12934: FTO_CTD (this model, PSSM-Id:289686 is obsolete and has been replaced by 432887)
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FTO C-terminal domain
This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.
Statistics
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PSSM-Id: 289686
Aligned: 12 rows
Threshold Bit Score: 210.661
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LFM_A       319 GTLDYILQRCQLALQNVC--------------D----D--------------VDnddvSLKSFEPAV--LKQGEEIHNEV 364 human
XP_012409272 326 GTLDYILKQCQLVMQNVW--------------D----Dme----------pkTM----HLRSLEPSV--VKQGEEIHNEV 371 Tasmanian devil
NP_001017273 322 DTFQYIKSQCNSALQNLH--------------MdpdtG--------------AA----ALKSLEPRV--LGQTEEIHNEV 367 western clawed ...
ADH02258     291 GTLEYIFGQCELALQNLQtd----------snS----T--------------AL----SLKSLETAV--IKQMEEIHNEV 336 rock pigeon
Q00Y15       517 DTFQYIKRRCLEALALIP--------------D----L--------------EN----KSASLDAKK--IQLLAEIHREV 558 Ostreococcus tauri
XP_009301626 405 GTLDYIQKRCSEALENLH--------------SdpekN--------------AK----SLISLLPSI--LQRIEDIHNEV 450 zebrafish
XP_006641538 130 GTLDYIQRRCQEALKFLR--------------SdldsG--------------TH----TLRSLEPSV--LQHCEEIHNEV 175 spotted gar
XP_001420808 251 DTFQYIKRRCIDALAIVP--------------D----L--------------ER----ENKPLDAKQ--IQFLADVHREV 292 Ostreococcus lu...
XP_002502764 334 DTFDYVRGRCERALAVLP--------------S----LkwragrwpkgtkppRD----ASSTQLSDA--VRVLGETHREV 389 Micromonas sp. ...
XP_003060875 338 DTFEHIKTRCERALRLLPgikkiaqvgpgpgdD----L--------------AA----FARS-------AQMMGETHREC 388 Micromonas pusi...
XP_002287957 366 GTWQYIRDKTKQVLDAST--------------K----Fnsse-------ktcQA----SKKTFEKFVahVRLQQLLMNEV 416 Thalassiosira p...
XP_004347827 456 GTRDYIVNLCNSAIADA-----------------------------------LI----SGSHFDLMS--VTKVQQALTEV 494 Capsaspora owcz...
3LFM_A       365 EFEWLRQFWFQGNRYRKCTD-WWCQPMAQLEALWKKMEGVTNAVLHE-V-KREGLPVEQR--------NEILTAILASLT 433 human
XP_012409272 372 EFEWLRQFWFHGHRYKKCTD-WWHLPMSELEGLWKKMECVTNAVLCE-I-RKEGLPMEQK--------NEIITDLLALLT 440 Tasmanian devil
NP_001017273 368 EFEWLRQFWFQGKRYNKCTT-FWKEAMTELENHWKQMETMTSLVLKA-I-ENENLTVDEK--------CNILKNILPCLV 436 western clawed ...
ADH02258     337 EFEWLRQFWFQGKRYLKCTD-WWLKPMAKLEEFWRKMELMTSLVLQE-V-RKKEQTEEQR--------NETISCLLLVLT 405 rock pigeon
Q00Y15       559 EFQWIRMFHLQGDTHARQHKtYWTQRIAELTEAWDRMEACFRAILSK-L-KLSPESTPQP--------SRAYSMMLYAMK 628 Ostreococcus tauri
XP_009301626 451 EFEWLRQYWFQGRRYARFCS-WWTKPMEQMEKDWKEMERMTQLLLVV-V-EDEATAQENR--------REMADVLLNALT 519 zebrafish
XP_006641538 176 EFQWLRQYWFQGRRYEKFCS-WWRKPMEELEEAWRKMEIMTQLALAE-A-EDAARTMERR--------REVAQVLLPFLT 244 spotted gar
XP_001420808 293 EFQWIRMFHLQGEAHAAWHDtYWTRKIAELTEAWDRMEACFRVILSK-L-KRSSRSPESP--------PRAYAMLLYALK 362 Ostreococcus lu...
XP_002502764 390 EFQWIRMFWLQGTRHAAQHDgYWTRRIEELTQAWDVMELGLRFAMDAcA-RAADGKAKAE--------PRAFEMLRYLLE 460 Micromonas sp. ...
XP_003060875 389 EFQWIRMFWLQGSRHAASHSaYWRQRIAELTQAWDAMELGYRWALDA-L-RAGASTGAMP--------LRAYDVVSYLLE 458 Micromonas pusi...
XP_002287957 417 EFEWLRQWYVQGSKHASLHP-YWHQPIEVLCDSYSNMEQRSVDLLVR-M-KRASHDNKTEtfnt-elsEDLFDVFIETLT 492 Thalassiosira p...
XP_004347827 495 ECGWIRQFWAHGLRHARIQA-FWKRVIESLELQWQQLESLTRQSLDS-ItRHMSEALHTAtksenariATICDALLKAFE 572 Capsaspora owcz...
3LFM_A       434 ARQNLRREWHARCQSRIARTLPADQKPECRPYWEKdd--------aSMPLPFDLTDIVSELRG 488 human
XP_012409272 441 TRQELRMEWCMRCQSRIAQNLPEEQRPICWPYWEDdd--------pEMPLPFNLSNIILELQG 495 Tasmanian devil
NP_001017273 437 ERQNLRQEWRERCRSKLAKKLPPDQAPCCYPYWNDdn--------kSMPLSFDLHSITFALQN 491 western clawed frog
ADH02258     406 ERQRLRNEWAARCQSEAAESLPEEQKPECHPFWTNee--------sNMPLPFDLEEVIVHLQN 460 rock pigeon
Q00Y15       629 EVKELRDEHVKRISASAYAALPESQRPVDLPQYDD-----------TSPLPFELKPVIYFVEA 680 Ostreococcus tauri
XP_009301626 520 DRQQHRQTWRDRCQSSLAQTLPPEEAPVDRPYWSNdd--------pDMPLPFDLSDIINRVES 574 zebrafish
XP_006641538 245 ERQERRQLWRARCHSRLAQTLPPDEAPMCRPDWHDdd--------sSMPLPFDLKAIIDALER 299 spotted gar
XP_001420808 363 TVKELRDEYTKRTKASAYASLPPSQRPVDLPAYDN-----------TSPLPFELKPVIYFLEE 414 Ostreococcus lucimarinus CCE9901
XP_002502764 461 TIAELREEHDARTQSGAYAQVPDDCKPVDLPGFDD-----------SSPLPRNLRPVLNTLER 512 Micromonas sp. RCC299
XP_003060875 459 ETRELRAEHARRSRAGAYEAMPADCRPVDEPKFDE-----------KSPLPFDLGPVLATLAG 510 Micromonas pusilla CCMP1545
XP_002287957 493 ERSNQRSGWTARYRDPIFGEIPADERPFPCPLLDRtgdmtldeslkKGQMPEDLENVIAKLRE 555 Thalassiosira pseudonana CCMP1335
XP_004347827 573 HRLRLREQWANFYSSPDFDHMENDLLPVRRPHFSA-----------SSPLPEALEPKIAQLVk 624 Capsaspora owczarzaki ATCC 30864
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