Conserved Protein Domain Family
3-PAP
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pfam12578: 3-PAP (this model, PSSM-Id:289355 is obsolete and has been replaced by 463634)
Myotubularin-associated protein
This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.
Links
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Statistics
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PSSM-Id: 289355
Aligned: 25 rows
Threshold Bit Score: 92.0657
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3V1L6       553 QQQSLMVPGPPSsmwlfsrGTLTPLNQLCPWQDSSSLLAVSShwlprPARSSESLAdqEWGLPSHWGACPLPP-GLLLPG 631 house mouse
A2BGG1       551 LSLPSSAFKTPT-------KKGFFKDETDSLKKMLRVKRISR-----WMGSPDSPVvaSREFYESWQQRPLDYhGLLLPS 618 zebrafish
A0JMF6       553 KNYSSTVRGLPSl-----mRNGSLGPNDTLTRRNSLVLRLRSdl--sQVREQPETP--SERFVRDFFSRAVDLqGLLLPQ 623 zebrafish
XP_006628855 541 KYHSSTMRGMPs------lRNGLMSEQDSIPRRNSLVLRLKPdf--sQLREPQDSP--SEQFFRDWLSRPPDLqGLLLPQ 610 spotted gar
XP_003442317 550 KAYSSTLRGPPTn-----lRNGVKGGEETLTRRSSLANELKSel----tPVKDESP--SERFFKDWFSRPADLqGLLIPL 618 Nile tilapia
XP_007241217 330 KNYSSTLRGVPTa-----lRNGVSNDHDTLPRRNSLMPRLRPdl--aQLREQQESP--AERFLQDWLSRPADPqGLLLPQ 400 Mexican tetra
XP_005060585 497 RQLSLPLTQAKPs-----tKRGFFREETDHLIKNILGKRIGK-----FINSSDEPPnsLREFYDSWHSKPVDYhGLLLPR 566 collared flycat...
XP_002745130 561 RQLSLPLTQSKSs-----pKRGFFREETDHLIKNLLGKRISK-----LINSSDELQdnFREFYDSWHSKPTDYhGLLLPH 630 white-tufted-ea...
XP_007250531 555 LSLPSSAFKTPP-------KKGFFKDETESLKKMLRVKRISR-----WMASPDSPAanTREFYEAWQRRPLDHhGLLLPW 622 Mexican tetra
XP_002412392 509 rayrNVWDWSGPesrlsaqDLELFQNPLYLLRRSRELLNAGRpv--pPPLPPSGSG--DRR------CAPSEDeDLLSMD 578 black-legged tick

Q3V1L6       632 YLGPQIRFWKRCYLRGRPEVQMGSSAL------------TVSALQDELSHLQELLRQWTPRISP 683 house mouse
A2BGG1       619 LDGPSVRIWMQRYLRWIPEVHIMGGGSvai-------mtKLMELLSQVEDLKRVLEQRDPSLAT 675 zebrafish
A0JMF6       624 LLPSHLSVWKLYFLRWVPEAQIPHGGPvta-------fhKLSVLTDEIEMLQNQLRQYKGAAGT 680 zebrafish
XP_006628855 611 LLPSHIKLWKLYFLRWIPEAQINGGGFita-------fhKVSLLADEIEKLQNQLRQYKGNPCP 667 spotted gar
XP_003442317 619 LMPSHMAFWKLFFLRWVPEACISKGGPvtt-------yhKLSQLVDEIEILQSQLRQYKGTSPG 675 Nile tilapia
XP_007241217 401 LLPSHLPLWKLYFLRWVPEARIPHGGPvta-------fhKLSVLADEIEMLQNQLRQYNGGATP 457 Mexican tetra
XP_005060585 567 IDGPEIKVWAQRYLRWIPEAQLHGGGTiat-------aaKILDLMEEVQSLQVKMDEERSQAVS 623 collared flycatcher
XP_002745130 631 IEGPEIKVWAQRYLRWIPEAQILGGGQvat-------msKLLEMMEEVQSLQEKIDEKHHSQQE 687 white-tufted-ear marmoset
XP_007250531 623 LDGPAVRLWMQRYLRWIPEVQILGGGPvav-------tnKMAELLVQVQELRKKLDLKGCWQPE 679 Mexican tetra
XP_002412392 579 ATVKALSVWTQCYFRWVPKAEVVNGDPgtlflhnvrvarDIQFLAAQV----RLLREHRRDGVE 638 black-legged tick
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