Conserved Protein Domain Family
MTP18
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pfam10558: MTP18 (this model, PSSM-Id:287521 is obsolete and has been replaced by 431357)
Mitochondrial 18 KDa protein (MTP18)
This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.
Links
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Statistics
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PSSM-Id: 287521
Aligned: 84 rows
Threshold Bit Score: 181.617
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0CVQ1        19 PYRYAGYANRL-RTILLSAHRYVAYTSDIGESFRPVAHPYLVRSAYAISWSYLIGDVVHEGYK--AYLRNRRVLAppcda 95  Aspergillus ter...
Q5UNZ8        14 SLKYAGPMSRLaRAF--SGFRMASYASDVGEATRGTFPNQFVHSMYAVTISYIFVDL-YFRYKdnKHLSNNKQCD----- 85  Acanthamoeba po...
GAA99527      50 NARYLAYLARL-RPLLLPATRYLAYTSDVGEAFRPVVNPTAVRAAYGISWMYLVGDVAYEGFR--ATKEREARAE----- 121 Mixia osmundae ...
CCU98199      23 igRYTAYTMRL-KTLITTGSRYIAYSSEVGEAIRPLARPIVVTAAYAISWAYIFGDVGYTCWQ--ASKGMDK-------- 91  Malassezia symp...
XP_001730783  24 lgRYSAYTMRL-KTLVTSVSRYIAYTSDVGEAFRPLTRPIVVTSAYAISWAYIFTDVGWTCWQ--AAKLQDR-------- 92  Malassezia glob...
XP_006682338   9 PLRILGYAGRL-RNFVTAGSRYLAYTSDMGEAFRPVVPRSVVNAAYGVSFAYVGIDVAYEGYK--SSLRGDSPME----- 80  Batrachochytriu...
XP_002668115  37 SLRYLGYLGRL-KTAIVAGARYLAYTSDVGEAFRPIVHPLIVRAGYGISWAYVLGDVGIQTYR--EKEKGSSTNT----- 108 Naegleria grube...
EST07135      80 pERYAAYFMRL-KTVIIASSRYVAYTSDIGEAFRPLTKPAVVKAAYGISWTYILGDVFYAGYK--AAKQYEALASttfts 156 Pseudozyma bras...
XP_012191542  84 pgRYAAYAARL-KTAVGSSLRMSAYTSEMGEALRPLTKPWVVRGAYAVSWTYIIVDVAYAGFK--AAKQYESLASttfsa 160 Pseudozyma hube...
GAC75419      82 PSRYAAYAMRL-KTVIVASSRYVAYSSDIGEAFRPLTSPAFVRGAYAVSWTYILGDVVYAGYK--AAQQYEALASttfsk 158 Pseudozyma anta...

Q0CVQ1        96 ykdasnvalgmvtgnlsgp-------------------------ltsaspaassavttdkdtltpwptTR---------- 140 Aspergillus ter...
Q5UNZ8        86 --------------------------------------------------------------------SK---------- 87  Acanthamoeba po...
GAA99527     122 --------------------------------------------------------------------KRtaldrltgrg 133 Mixia osmundae ...
CCU98199      92 --------------------------------------------------------------------DS---------- 93  Malassezia symp...
XP_001730783  93 --------------------------------------------------------------------DS---------- 94  Malassezia glob...
XP_006682338  81 --------------------------------------------------------------------VT---------- 82  Batrachochytriu...
XP_002668115 109 --------------------------------------------------------------------VL---------- 110 Naegleria grube...
EST07135     157 ssgplqeleteaaryadkalssvkqnlpleklldhktlstlsptekvelrkrhtqrlaeagqhagvdpNQ---------- 226 Pseudozyma bras...
XP_012191542 161 tgpvqeleteaaklanqtlssvrenlpleev-ldsktlsalspsekvelrkrhtqrlaehgrhagvdpSK---------- 229 Pseudozyma hube...
GAC75419     159 sgpvqeleseaaqladkaltsarenlplekl-ldaktlnalsptekvelrkrhverlaeqgdhagvdpNQ---------- 227 Pseudozyma anta...

Q0CVQ1       141 ---IPLAEDYRMVMAKRAVFQSVASMGLPALTIHSVVKYSGRMLKNS--KMVFFRTWAPIGLGLSVVPFLPYIFDEPVEE 215 Aspergillus ter...
Q5UNZ8        88 ---MTEFQKY---MGYHTLWHAQASLFFPTITIHSIVSSTKEFTANInwLNPKVKKFAPVCLSLALIPCLIKPIDDLADK 161 Acanthamoeba po...
GAA99527     134 iedLSASTEVGLRVVKRATFQATASMLFPALTIHTTVKQSGRLFKNA--KSPRVRAWGPTVLGLAVVPALPYIFDEPVEH 211 Mixia osmundae ...
CCU98199      94 ---PTRTTDLAWIAARRGTFQTLASLYLPALTIHSIVRFSGPVFAKF--RSVRVRALGPSVLGLFTIPLLPLLFDHPVET 168 Malassezia symp...
XP_001730783  95 ---PTLASDIAWIAARRGAFQSLASLVLPAVTIHSVVKHSAHLFAKF--KSSRVRVAGPTAAGLLVVPLLPIVFDDPVET 169 Malassezia glob...
XP_006682338  83 ---RT--------VVERTIFQGLASLLLPAITIHSVVDLTTKALKNT--SINALKRWGPTAAGLAVLPVLPILLDRPVEY 149 Batrachochytriu...
XP_002668115 111 ---RT--------ATKTAIFQSTASMILPMITIHQTVHVVSAILKKVgyKSKVI----PTISGLAVIPALPFMFDHPVEH 175 Naegleria grube...
EST07135     227 ---ISEVTHVGLTMARQAVFQSIASMALPAFTIHSIVRYSAPLFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEH 301 Pseudozyma bras...
XP_012191542 230 ---VSEVTHVGMTVARQAVFQSIASMALPAFTIHSIVKYTAPVFAKA--KNHRIRAFGPTAAGLMFIPALPFLFDEPVEH 304 Pseudozyma hube...
GAC75419     228 ---VSEATHVGVVMARRAVFQSIASMALPAFTIHSIVRYSAPVFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEH 302 Pseudozyma anta...

Q0CVQ1       216 AV 217 Aspergillus terreus NIH2624
Q5UNZ8       162 IM 163 Acanthamoeba polyphaga mimivirus
GAA99527     212 GV 213 Mixia osmundae IAM 14324
CCU98199     169 AV 170 Malassezia sympodialis ATCC 42132
XP_001730783 170 VV 171 Malassezia globosa CBS 7966
XP_006682338 150 VM 151 Batrachochytrium dendrobatidis JAM81
XP_002668115 176 FV 177 Naegleria gruberi strain NEG-M
EST07135     302 VI 303 Pseudozyma brasiliensis GHG001
XP_012191542 305 VV 306 Pseudozyma hubeiensis SY62
GAC75419     303 VI 304 Pseudozyma antarctica T-34
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