Conserved Protein Domain Family
Med11
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pfam10280: Med11 (this model, PSSM-Id:287280 is obsolete and has been replaced by 463042)
Mediator complex protein
Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organization is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.
Links
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Statistics
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PSSM-Id: 287280
Aligned: 89 rows
Threshold Bit Score: 50.3439
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6C590        60 SERLESLHKTDMKIAKMTETLSNAIDLLIPrseldinsfelkegdkgwepgiqQGLPsLKSAFKVNSIEFLQSLEE-VST 138 Yarrowia lipoly...
Q9BI74        11 TDRIQAIVTTEKSIDEMMKCAREIIQDLGK------------------------EKQiGKNKMEDNANNFKKLITQ-VEN 65  Caenorhabditis ...
Q6P255         8 NERLRALEEIEREIAAILLNAGNVILELSK-------------------------EKpNERVLDKQATQFTASVQR-VES 61  western clawed ...
XP_974541      5 mERIQVLDSIEKDIITCLHSAGQVFVELSK-------------------------EKsSLKQAENHTQTFLKTLGA-VES 58  red flour beetle
XP_008215113  37 mERIQILEAIEKDIITCLQSAGQAFMELSKd-------------------------KpNSKQAEGQTHQFIKTLGL-VES 90  jewel wasp
NP_001156198   5 mERIQALELIEKDIITCLQSAGQALLELSK-------------------------EKsSLKQVENQSHQFLKSLGN-VES 58  pea aphid
XP_008854114   8 NERLRALEDIEREIGAILQNAGTVILELSKekt------------------neRLLDrQAAAFT-------TSVQH-VEA 61  Upper Galilee m...
NP_001187819   3 NDRLRALEDVEKEIAVVLQCAGTIVLELSK-------------------------EKhNASLLDRQLNQFQTSINR-IEN 56  channel catfish
XP_001640033   5 RDRLKQLEEIEKDIVKVMQSAGETIAELSN-------------------------ENpSEDMVNMKATEFVKSLEG-VEK 58  starlet sea ane...
EFA79080       1 mnSLTVLNNIEDRVVESINTAGKALNILSKsl-------------------diKQTTpSIQEFKQLSDRYFNIVEKdVYK 61  Polysphondylium...

Q6C590       139 TLRKEIKRLNDfs-----------rdKVLPIN------TDTKAQWTS--LENYDKIINQ-IKGM 182 Yarrowia lipolytica
Q9BI74        66 ELSAQMQYLSHvcvgsshqgstfgvlQNSLLAqsglssLHSELFQIV--RYLDPtsdepqttee 127 Caenorhabditis elegans
Q6P255        62 ELSGQIRYLTQvatgqphegssysarKDGTMAlnridyARVKLAELS--RT---------CDQM 114 western clawed frog
XP_974541     59 KLTEQINYLTQvstgqphegsgyasqKVLQMAwhrlehARSRVNELD--RLKLKHMqgrrvqpp 120 red flour beetle
XP_008215113  91 KLSDQINYLTQvstgqphegsgyesqKVLQMAwhrlqhVRSRVDELE--RLKNKHMhsrslaal 152 jewel wasp
NP_001156198  59 KLTEQINYLTQvstgqpyensgyasqKVLQMAwhrlehARSRVKELE--RSKNKYLqdqeqlkg 120 pea aphid
XP_008854114  62 ELSGQIRYLTQvatgqphegssyssrKDCQMAlkrvdyARLKLSDVA--RTCEQMLENE-VKEM 122 Upper Galilee mountains blind m...
NP_001187819  57 ELSSQIRYLTQvatgqphegstysarKDCQMA----------LNRAEyaRVKLGELRRT-CETM 109 channel catfish
XP_001640033  59 GLTEQINYLTQvatgqphegstygvdKDFELAtsrtaiVKGQLQEVQ--KILKNptvakt---- 116 starlet sea anemone
EFA79080      62 GLMEFVDSMTDvapfdh---ssysnkCELDVShnfteiILLHL---------------EeMEEI 107 Polysphondylium pallidum PN500
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