2AUH


Conserved Protein Domain Family
BPS
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pfam08947: BPS (this model, PSSM-Id:286088 is obsolete and has been replaced by 462644)
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BPS (Between PH and SH2)
The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.
Links
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Statistics
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PSSM-Id: 286088
Aligned: 11 rows
Threshold Bit Score: 81.8274
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AUH_B        10 SISENSLVAMDFSGQK-SRVIENPTEALSVAVEEGLAWRKKGSLRL 54  human
XP_003942889 366 SVSDNTLVAMDFSGHA-GRVIENPREALSVALEEAQAWRKKTNHRL 410 Bolivian squirrel monkey
NP_001102563 266 SVSENSLVAMDFSGQI-GRVIDNPAEAQSAALEEGHAWRKRSTrmn 310 Norway rat
XP_008293654 275 SVSENSLVAMDFSGRT-GRVIDNPVEAQSAALEEGQTWR-KRSQRM 318 bicolor damselfish
XP_004948654 355 SVSDSALVAMDFSGCT-GRVIENPSEVLTAVLEEAQAWRKKTTHRY 399 chicken
XP_012954431 283 SISENSLVAMDFSGHR-SRIIENPMEVLSVAVEEGLAWRRRGCLRL 327 mallard
AAH21820      37 SVSENSLVAMDFSGEK-SRVIDNPTEALSVAVEEGLAWRKKGCLRL 81  house mouse
ACO51148     100 SISENSLVAMDFSGHK-SRVIENPSEALSVAVEEGLSWRRKSCHRL 144 bighead carp
XP_004917759 282 SISENSLVAMDFSGQK-SRVIENPTEALSIALQEGLLWRRKSSGRI 326 western clawed frog
XP_006638252 439 CVSEASLVAMDFSGKAgGRVIENPREAQSAEQEEGQAWRKKTALRC 484 spotted gar
XP_005794862 407 SESENSLVAMDFTGKAgGRIIENPTEAQNAEQEEAQAWRKRETLRF 452 southern platyfish
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