Conserved Protein Domain Family
OPA3

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pfam07047: OPA3 (this model, PSSM-Id:284465 is obsolete and has been replaced by 462072)
Optic atrophy 3 protein (OPA3)
This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.
Statistics
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PSSM-Id: 284465
Aligned: 149 rows
Threshold Bit Score: 67.1106
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6C339         6 LKLTSLLVRTIAKPMATAIKGQAK---Q-------HPRFK-QICISLAQRLHQTDTNL----KM-------RLM--GK-- 59  Yarrowia lipoly...
A0CU80         5 KKLAALFIRTFSKPVANIIKRYAL---NnnnnrsfGRRIVrNSFIFLGNKYHAFDTYL----ER-------ASI--GQtn 68  Paramecium tetr...
A0BUL1         5 FKVFSLIVRVFARPVIARTKAAHL---Kkaq--sgHTTWIkQFYVRLGNFQHKWDQKI----DS-------KFM--GIdk 66  Paramecium tetr...
A0CNE2         5 LKLISLIVRVFARPIITSRKEVSI---Ekvl--msKQRFLtQQIQNLGNYYYYTDQKI----DR-------MYL--NQnl 66  Paramecium tetr...
EHJ73204       9 FRLATLLARQLSSPVATRIKRYAV---G-------NPKVGgRVCRCVAQSYHECEWMA----RT-------WAL--KMag 65  monarch butterfly
XP_001016702   5 FKLFSLFVRILARPVIARTKAHTSsklQ-------NQKFR-VFFVWLGNKAHRINVYI----NR-------TFLklNN-- 63  Tetrahymena the...
XP_008206277   9 saLLTQLFRQLTKPASQRIVDYAA---R-------HPSFRrYLLLAPGRLYHRLESHL----ERlkaapmvASK--AE-- 70  jewel wasp
EGI68336       9 anligqILRQITQPLSKAIVKRVK---K-------RPLIRkYVLMQLGHFYYLCENLI----EW-------RQI--SV-- 63  Panamanian leaf...
EKG07180      12 FRFFFLAIRQISKPVVKATVSRAK---R-------EATITrALCLSLGRFSLGISCVI----EK-------WNS--EDtt 68  Trypanosoma cruzi
XP_002141204   5 feLSRTIINTCSKRVVAFVVNHAS---N-------HPKSR-EKLIRFGQSSHRTYIHLkyfgSY-------WLD--RSff 64  Cryptosporidium...
Q6C339        60 ----ST-------------------------------------------------------------------------- 61  Yarrowia lipoly...
A0CU80        69 --qqFF-------------------------------------------------------------------------- 72  Paramecium tetr...
A0BUL1        67 --ksSD-------------------------------------------------------------------------- 70  Paramecium tetr...
A0CNE2        67 --hdEY-------------------------------------------------------------------------- 70  Paramecium tetr...
EHJ73204      66 islpKN-------------------------------------------------------------------------- 71  monarch butterfly
XP_001016702  64 ----QD-------------------------------------------------------------------------- 65  Tetrahymena the...
XP_008206277  71 ----KK-------------------------------------------------------------------------- 72  jewel wasp
EGI68336      64 ----IT-------------------------------------------------------------------------- 65  Panamanian leaf...
EKG07180      69 --rrSDgswansgrsdarenqakegflvaprsrsllqk--------------nvapggsdgtqrigrlflrlpmqtawga 132 Trypanosoma cruzi
XP_002141204  65 --isSTsrnyinsktipnnephlkyctdidffnspstspeskfatytlfsqskasrsnqclvtpsqtsplppvsslpvks 142 Cryptosporidium...
Q6C339        62 ---FKVRPLNEAKAIES---------GATFVAEGFIFSVAGGLILYESFRARRKELNRRETVADD-------IET-LQDE 121 Yarrowia lipoly...
A0CU80        73 -----IKPLTDEAAFMK---------GTDLFSDLFIYACVLGLPLYEIMRQSNESAKKEAIQDEK-------LHK-LSKE 130 Paramecium tetr...
A0BUL1        71 ---FFFKPLNDELALEK---------GVEFFYEILIYALLITLPTYEMYSAQQDSKKKSEQNTQK-----------LNNL 127 Paramecium tetr...
A0CNE2        71 ------DKLNDEDALKLvilitiilqGTEFLLEMIIYTILILVSLFEIYKTYF---EQQERLQNMnn----tIKN-LQQQ 136 Paramecium tetr...
EHJ73204      72 ---ARAPPLRDQTALNL---------GGDLLGEIIIFTIGSLIIIFEVNRQADIKETKELDEKSEwlaimlsLEE-IQRE 138 monarch butterfly
XP_001016702  66 ---FKVQDLSEPAALEL---------GVETFYEVIIYACILGLPIIEIYRAQVESNEKSEKQKQV-------MEG-IHTR 125 Tetrahymena the...
XP_008206277  73 ---PKVKALKDEEAAML---------GSQLMIEIVIFALLALILTCDWLRSQRKSALEEDRRRAE-------FAE-LERQ 132 jewel wasp
EGI68336      66 ---KK-RPIDDDRTMEV---------GTSLLLEAIIFGFLGGVVIYETQKAADRACIAEELQIQE-------FND-IKAK 124 Panamanian leaf...
EKG07180     133 frsAYSPSIDEERLVKI---------GAEVLIELLVYSILSAALYFELSTASKASEAKEACLLQR-------IEA-LERK 195 Trypanosoma cruzi
XP_002141204 143 ritLNVKPLDESKAFEV---------GVDTAADLSVFAITLSLVCTSLWMRRRRQ-QKSQKLQKE-------SEKiLLAR 205 Cryptosporidium...
Q6C339       122 IE 123 Yarrowia lipolytica
A0CU80       131 VE 132 Paramecium tetraurelia
A0BUL1       128 MK 129 Paramecium tetraurelia
A0CNE2       137 IK 138 Paramecium tetraurelia
EHJ73204     139 VQ 140 monarch butterfly
XP_001016702 126 LQ 127 Tetrahymena thermophila SB210
XP_008206277 133 ks 134 jewel wasp
EGI68336     125 kd 126 Panamanian leafcutter ant
EKG07180     196 VN 197 Trypanosoma cruzi
XP_002141204 206 VE 207 Cryptosporidium muris RN66
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