1FJR


Conserved Protein Domain Family
Methuselah_N
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pfam06652: Methuselah_N (this model, PSSM-Id:284145 is obsolete and has been replaced by 429053)
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Methuselah N-terminus
This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site. This family is found in conjunction with pfam00002.
Links
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Statistics
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PSSM-Id: 284145
Aligned: 36 rows
Threshold Bit Score: 198.223
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1FJR_A         5 CDYFDTVDISAAQKLQ---N------GSYLFEGLLVPAILTGEYDFrILPDD-SKQKVARHIRGCVCKLKPCVRFCCPHD 74  fruit fly
Q29ET6        57 CTFFDTVNLTGYTPFP---N------GSYSYEGVLIPSHLVGQYNY-IYKDLvERVDVDWHPRGCICRLKACLNICCPWG 126 Drosophila pseu...
XP_002012032  54 CSFFDTVNLTGYPSFP---N------GSYNYEGVIIPSHYVGTFDY-IYKDLvDRIDVTPHVRGCICKLKPCINICCPWG 123 Drosophila moja...
XP_001955867  53 CKFHDTVNLTGHTRFP---N------GSYEYEGIIIPEHLVGNYDYvFRSLA-DRVEVPNHVRGCVCKLKPCLNICCPWG 122 Drosophila anan...
NP_612030     56 CNFYDTVNLTGHRLFP---N------GSYDYYGTIVPAELVGTYDY-IHSSLtERIEVREHVRGCVCKFKSCLNICCPWR 125 fruit fly
XP_002046452  32 CAFIDTANITGGYNMG---NlggslnGSYVYNWTVIPKELVTAYDF-VIENG-IRVPAARHLRACVCKLRPCVRFCCPAG 106 Drosophila virilis
XP_002012035  31 CAFIDTVNITGSYNMGsslN------NSYVHNWTVIPRELVTAYDF-IIENG-IRVPAKRHLRACICKLRPCVRFCCPAG 102 Drosophila moja...
XP_002065959  40 CAFIDTTNISGSYAMDssfN------GSYIHNWTVIPREWVAIYDF-VIEDG-VRVPARRHLRGCVCKQTPCVRFCCPDG 111 Drosophila will...
XP_001983629  33 CAFIDTVNITGSYRMDgslN------NSYVHNWTVIPKEFVTDYDF-VIENG-IRVPTERHLRACICKQRPCVRFCCPNG 104 Drosophila grim...
NP_611998     30 CAFIDTANITGSYGL----D------GPFVHNWTVIPRHFVAVYDF-VIENG-IRIPASRHLRACVCKTKPCVRICCLRG 97  fruit fly

1FJR_A        75 HIMD-N-Gv--CYDNm--SdeelaeldP-FLNVTLDDGSVSRRHFKNELIVQWDLPmpCDGMFYLD-NREEQdKYTLFEN 146 fruit fly
Q29ET6       127 QVYN-S-EkeeCNNDt--Tdtri-wpqP-VMNVTFDNSSTQSVNIFKQFAVQSFRP--CPKMFSLQpEINDFdDYLLFQN 198 Drosophila pseu...
XP_002012032 124 QIYN-Y-Te--CQKDt--Ntkqk-wpeP-LINVTLNNGSVQSVNIYEQFVVQSFRP--CTEMFSLVpEVNSYdTFQLYEN 193 Drosophila moja...
XP_001955867 123 QIYN-S-GrgeCMNDt--Mdhre-wpkP-VLNVTFAENITMEVNISQQFAVQSFRP--CAKMFSLQpEINDFdAYLIFQN 194 Drosophila anan...
NP_612030    126 QVFN-S-EvdgCIIDh--Sdnrt-wpdPpMLNITFRNESTILVNMFTQFAIQSFRP--CPKMFSLQpETNNWdDYLLFEN 198 fruit fly
XP_002046452 107 QLYE-L-QrrrCVAPt--GdgpqppghS-HMTVELHNGSRLSIELRARFSVHVETP--CDHMRALTkDSVYL-NWTLHEN 178 Drosophila virilis
XP_002012035 103 QFYD-L-EersCLAAq--EqlppppgqS-HMAVQLHNGTQLDIELRSLFSVYEETP--CDHMKAYTkDNTYL-NWTLHEN 174 Drosophila moja...
XP_002065959 112 QIYDlN-Ek-qCRQPhsmSvnnlppdhS-HMDIELNNGSLRHIELRSLYSIHVETP--CKHMKALRkNMEYVh-WTLHEN 185 Drosophila will...
XP_001983629 105 QLYD-LqDh-kCVPHs--AehpqppghS-HMTVGLRNGTQLQMEIASRFSVHVETP--CDNMRAVIkDGDYF-NWTLYED 176 Drosophila grim...
NP_611998     98 EIYD-L-EkrqCLVPv--AgvsslpshS-HMEVELGNGSLRLVKLQPRFSIHVETP--CEHMKAVTkGSEYVh-WTLHEN 169 fruit fly

1FJR_A       147 GTFFRHfdRVTLRKREYCLQHLTFADGNatsIRIAPHNC 185 fruit fly
Q29ET6       199 GSMLRLddHNYINKSEFCLVVSYVNETDl-yYSLNPANC 236 Drosophila pseudoobscura
XP_002012032 194 GTLFREddQHYIFKNEFCLVPTSINDTDl-yYTINPANC 231 Drosophila mojavensis
XP_001955867 195 GSMFRVddKVFIEKNQYCLVPTFVNESDl-vYSLNPANC 232 Drosophila ananassae
NP_612030    199 GSMLRVddKLLIRKNEFCMVPTYVNESDm-fYTIHPANC 236 fruit fly
XP_002046452 179 GSITH---REHLFTKHYCFTPLRVGNSS---WNWQPLAC 211 Drosophila virilis
XP_002012035 175 GSIIH---RDYLFSKHYCFSPLLIGNSS---WSWQPLAC 207 Drosophila mojavensis
XP_002065959 186 GTITH---RGHMFTKHYCFTPLQLANAS---WDWQPLAC 218 Drosophila willistoni
XP_001983629 177 GSIIH---REHLFTKHYCYTLVLLGNRT---WSWQPLAC 209 Drosophila grimshawi
NP_611998    170 GTISH---RGHIFSKHYCFTPLLHGNST---WEWQPLAC 202 fruit fly
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