1TH1


Conserved Protein Domain Family
APC_crr
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pfam05923: APC_crr (this model, PSSM-Id:283553 is obsolete and has been replaced by 461781)
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APC cysteine-rich region
This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Links
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Statistics
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PSSM-Id: 283553
Aligned: 45 rows
Threshold Bit Score: 30.0897
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TH1_C         10 SPPEHY-VQETPLMFSRCTSVSSLD 33   human
XP_009018419  985 DTLKVYaEEGTPFEISRVTSLSDIS 1009 Helobdella robusta
XP_783363    1945 DTPRVFaVEGTPINFSCNGSLSSLS 1969 purple sea urchin
XP_011665957 1869 DSPRVFaVEGTPGIISRADSLSSLS 1893 purple sea urchin
XP_007250389 1429 DTLIHFaTESTPDGFSCASSLSALS 1453 Mexican tetra
XP_011385647   91 AGSVRFtVEKPDENFSCASSLSALa 115  large flying fox
XP_001955695  721 DKLNRFhVEHTPAVFSCATSLSNLS 745  Drosophila ananassae
EHJ78123       40 ERPAQFvVENTPAHFSANTSLSSLT 64   monarch butterfly
XP_004925304 1234 ERVSRFvVEHTPAQFSANTSLSSLT 1258 domestic silkworm
XP_002000958 1085 DDLSKFnVENTPAQFSGATSLSNLS 1109 Drosophila mojavensis
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