Conserved Protein Domain Family
TROVE
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pfam05731: TROVE (this model, PSSM-Id:283406 is obsolete and has been replaced by 461724)
TROVE domain
This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
Links
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Statistics
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PSSM-Id: 283406
Aligned: 26 rows
Threshold Bit Score: 262.695
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q231I6         27 NQND-----IQVRVKIDDPKQYLVNVTAAC---LLQEGSYYQDK-------DERRYIITKALLEV-----AESDPEFICQ 86   Tetrahymena t...
Q27274         63 VENNaggfvFPVSDETQVRRFLILGSDKGSyhqSSEKITIDNAQriikiieQGNGHMVLKELALInaenrNPKMNAMIFT 142  Caenorhabditi...
EGT55430       64 VKNNaggyvFQTSDETQVRRFIIIGSDKSSyyqSAEKMTMENAQriieiveSGKGHMVLEQLARInaenrNPKMNSMLFT 143  Caenorhabditi...
XP_003373098   44 avNDaggsgFEVSRIMRLKRFLILGTEGGTfyvSEKQLTKENAInvlymieNNRGMEVLEQLVEVslagrAPKQTATLFC 123  Trichinella s...
XP_011456874   38 VMNStggyvYSTDYVTQLMRFLCIGTTGGTyytGEAELTRENTRcidrlinSGRGKDVVELVREFsvgnrSCKQRPLLYT 117  Pacific oyster
XP_001698480   16 VRNNaggfvFKVDDLTLLRRYIILGSDANNyyvSRKSVDLASAQcvarllaAGQGEAVVKELVDIsregrAPKQATGIVV 95   Chlamydomonas...
KKA65036       55 kKNSegyvtLALSDENRIRRFLILGATGGTfyaKEQKLTMENVQalkeiiiRGGASTILETLREVsiagkSQKQEAILLA 134  Pristionchus ...
WP_011727486   23 VRNAaggytFPVDDWARVHRFLTLGTDGGTyytADRELTRDNAEvvl-rvaATDPVGLVNRIVEVseagrAPKANPALFA 101  Mycobacterium...
ERG85813       62 VRNTaggyvFKVNDLNRIRRFLILGTEGGTyysSEKQLTMDNVKamceiieKGKGPLLLREIIRIslegrAPKQDPTLFA 141  pig roundworm
XP_005341459  206 TSEDseshlEPTDQVLQEKKMALMSLLCST---LASNVNVKDAY-------DPTQVSILEVCTEL-----APLEPVFILK 270  thirteen-line...

Q231I6         87 LAVYIRNELYIRTTTN---------------------------------------------------------------Y 103  Tetrahymena t...
Q27274        143 LAICARISTHDTTKKTecpmlnay------------------------------------------------sdyiralH 174  Caenorhabditi...
EGT55430      144 LAICARIATHDTSKKNrecpvida-----------------------------------------------ysqyirelH 176  Caenorhabditi...
XP_003373098  124 LALCARHSAEIMDRENgn-----------------------------------------------------------qlR 144  Trichinella s...
XP_011456874  118 LALCCRSNDPVTKHEG---------------------------------------------------------------- 133  Pacific oyster
XP_001698480   96 LAMCARLGDPASRRA----------------------------------------------------------------- 110  Chlamydomonas...
KKA65036      135 LGLCSRFGVSSLSSAPsdlaahpf------------------------------------------------yvylremH 166  Pristionchus ...
WP_011727486  102 LAIAASSEDVDGRRA----------------------------------------------------------------- 116  Mycobacterium...
ERG85813      142 LALCARYKVRDTTRPNihnqvmkkykgktltqedceaivnevqertkesllanerskvagdgfeqqapqeayddyqkalQ 221  pig roundworm
XP_005341459  271 AALYTRQQLNIRDLAN---------------------------------------------------------------K 287  thirteen-line...

Q231I6        104 IVAFCVVHKNTQpfiekyfnkavlLPNDLLEVCEfaqvlyifdatefknlYlDRILSQ-----DI--------------- 163  Tetrahymena t...
Q27274        175 DSALDLIPEVCR------------TPTHLFEFVD----------------YcQTISES-----TKag------------- 208  Caenorhabditi...
EGT55430      177 AAALRLLPDVCR------------TPTHLFEFVD----------------YcQTISES-----TKag------------- 210  Caenorhabditi...
XP_003373098  145 QAAYNALPSVCR------------IPTHLFEFIG----------------FcKANSE----------------------- 173  Trichinella s...
XP_011456874  134 ---YNVLSDVCR------------IPTHLFEFIK----------------CcEEESAG---------------------- 160  Pacific oyster
XP_001698480  111 --ALSAVPAVCR------------TASTLFEWVQ----------------RcKELGAAaelrkTE--------------- 145  Chlamydomonas...
KKA65036      167 KEATGLVNTICR------------TATHLFSYVA----------------YcEMVAAD-----IIithdeevekrheepg 213  Pristionchus ...
WP_011727486  117 --ALAALPRVAR------------TATHLFLFAG----------------YvEQFR------------------------ 142  Mycobacterium...
ERG85813      222 NMAFRAVLKVCR------------IPTHLFAFVG----------------YcQKISAE-----TGa-------------- 254  pig roundworm
XP_005341459  288 VVAIAAFLPVCRphlrryfcaivhLPSDWIQVAEf---------------Y-QSLAEG-----DQ--------------- 331  thirteen-line...

Q231I6        164 ----------------------RKELTFRKCLQRCVRS--------KFSEFNEYQLGKYCTESQR-KKTMFRY----LS- 207  Tetrahymena t...
Q27274        209 --------------------gaKSSTGWGRSMRNAISKwy----ttKTTEKLAMLLTKYPQREGWsHRDLFRL----AHp 260  Caenorhabditi...
EGT55430      211 --------------------gsKSSTGWGRSMRNAISNwy----ksKTPKNLAMLLTKYPQRDGWtHRDLFRL----AHp 262  Caenorhabditi...
XP_003373098  174 ------------------------STCWGRSHRRAIANwy----lrKNPLDLVYLVTKYKNRHGWtHLDVIRL----AH- 220  Trichinella s...
XP_011456874  161 -------------------------TGWGRAHRRAIANwylnygkkGKGEFLALHMTKYKTRFGWnHKDVFRL----CH- 210  Pacific oyster
XP_001698480  146 ----------------------SGALTWGRAMRRTVARwy----ldKTAGAVAYQATKYSQRNGWsHADLLRL----VHp 195  Chlamydomonas...
KKA65036      214 hqarkrktremlekkekesapvRKSTGWGRVMRKCIQNwy----lsKTPEELAVAVTKYRARNGWsHKDLLRLshpiPR- 288  Pristionchus ...
WP_011727486  143 --------------------------GWGPTLRRAVSRwy----teRPVDALAYQLVKYRQRGGWsHRDMLRL----AR- 187  Mycobacterium...
ERG85813      255 ---------------------kQNSKGWGRGLRTAIAYwy----fnQTPERLAMLITKYQQRNKFcHRDLLRL----CHl 305  pig roundworm
XP_005341459  332 ----------------------TKLVPLPACLRAAMTD--------KFAQFDEYQLAKYNPRKHRaKRRPNRP----PRp 377  thirteen-line...

Q231I6        208 -------------------------VTNKQKWDQTKKKRkenlltklqaikesedkskretgdimnvedaikalkpavmk 262  Tetrahymena t...
Q27274        261 nlmdsrshgqsed------rlereqlfrfavkGDLVKRKrkmsveevaevekvwdk------------------------ 310  Caenorhabditi...
EGT55430      263 nlkkn--------------------------------------------------------------------------- 267  Caenorhabditi...
XP_003373098      --------------------------------------------------------------------------------      Trichinella s...
XP_011456874      --------------------------------------------------------------------------------      Pacific oyster
XP_001698480  196 dpeqhatk------------------------------------------------------------------------ 203  Chlamydomonas...
KKA65036          --------------------------------------------------------------------------------      Pristionchus ...
WP_011727486      --------------------------------------------------------------------------------      Mycobacterium...
ERG85813      306 rpktsfpkshkywhh--hkefdfifayiagdtGDGHKRKaepegngikkaknenrkdetdeqrkkreekerervekqmar 383  pig roundworm
XP_005341459  378 prteplfseqkryfakslwplereqLEFEATYNAVPEKK----------------------------------------- 416  thirteen-line...

Q231I6        263 kiakrqnamkkhmkapkipnstlE--------------------------------------------------S----- 287  Tetrahymena t...
Q27274        311 -------kalklpyteeqlikeeQ--------------------------------------------------S----- 328  Caenorhabditi...
EGT55430      268 -----------------dgedsyE--------------------------------------------------R----- 275  Caenorhabditi...
XP_003373098  221 -----------------------P--------------------------------------------------K----- 222  Trichinella s...
XP_011456874  211 -----------------------I--------------------------------------------------K----- 212  Pacific oyster
XP_001698480  204 --------------rrkaparivL--------------------------------------------------S----- 214  Chlamydomonas...
KKA65036      289 -----------------------NdhqrivfehifyyatkgecqprkrlfpadtcwaetvrmkyteaqlveediS----- 340  Pristionchus ...
WP_011727486  188 -----------------------P--------------------------------------------------Sgvvdp 194  Mycobacterium...
ERG85813      384 mklreekvkifselklpeapdaeG--------------------------------------------------S----- 408  pig roundworm
XP_005341459  417 -----------------------N--------------------------------------------------Q----- 418  thirteen-line...

Q231I6        288 -K----------------------------------------------YL-------TF--------------------- 292  Tetrahymena t...
Q27274        329 -R----------------------------------------------AL-------NL--------------------- 333  Caenorhabditi...
EGT55430      276 -E----------------------------------------------YLfrfaatgDL--------------------- 287  Caenorhabditi...
XP_003373098  223 -PdsnqkeiddiflyiksglnsvlqrrvvnfeeksaeeiedivnnsgeLL-------KY--------------------- 273  Trichinella s...
XP_011456874  213 -Pevdhpeikylvmvstkgkektd---ksdfvqqekqkpeyensdlkkVM-------VF--------------------- 260  Pacific oyster
XP_001698480  215 -P----------------------------------------------VM-------QY--------------------- 219  Chlamydomonas...
KKA65036      341 -E----------------------------------------------GL-------LY--------------------- 345  Pristionchus ...
WP_011727486  195 aR----------------------------------------------RM-------AFnwaagkglgdyaeaparltdv 221  Mycobacterium...
ERG85813      409 -P----------------------------------------------AA-------KL--------------------- 413  pig roundworm
XP_005341459  419 -P----------------------------------------------RF-------TL--------------------- 423  thirteen-line...

Q231I6        293 -KDLIKFC----HI--------------------SEPK------------------------ER---------------- 307  Tetrahymena t...
Q27274        334 -VEAYLKL----KN--------------------EQSE------------------------EV---------------- 348  Caenorhabditi...
EGT55430      288 -KDRKRKAaadeKS--------------------TKES------------------------EKdkndqsdvp-----md 317  Caenorhabditi...
XP_003373098  274 -LYYLERL----KS--------------------SQDE------------------------LI---------------- 288  Trichinella s...
XP_011456874  261 -MDAVEKA----EK--------------------CRES------------------------DT---------------- 275  Pacific oyster
XP_001698480  220 -LVDAHRL----RKevrappplksaagkrgrdaaESDE------------------------EHedeadpeviaeheaat 270  Chlamydomonas...
KKA65036      346 -LERVSSL----SP--------------------YTSE------------------------EE---------------- 360  Pristionchus ...
WP_011727486  222 eLKVGQRT----AV--------------------RPPVraevvpdelaiiadfedaqaasaaAR---------------- 261  Mycobacterium...
ERG85813      414 -IRAFEEM----KA--------------------VTEP------------------------EK---------------- 428  pig roundworm
XP_005341459  424 -KKLVQRL----HI--------------------HEPA------------------------HH---------------- 438  thirteen-line...

Q231I6        308 ------VYKILGKKYpkteeeykaafgdSAsapfnpelagkrmkieiskTWEN------------------E-LSAKGNT 362  Tetrahymena t...
Q27274        349 ------IVAAI-KKH-------------GL-------------------VREH------------------L-PTTSLNS 370  Caenorhabditi...
EGT55430      318 teeqssVVGLV-EAYl------------RL-------------------KNEQneelivaaikkhglvrehL-PTSSLNS 364  Caenorhabditi...
XP_003373098  289 ------CAQLI-EKF-------------KF-------------------VREQ------------------V-PQRLLSS 310  Trichinella s...
XP_011456874  276 ------MTRLI-LEH-------------KL-------------------TREH------------------V-PTDLLKS 297  Pacific oyster
XP_001698480  271 aeavetALTLI-RRH-------------RF-------------------GHEH------------------VgDTVLLRN 299  Chlamydomonas...
KKA65036      361 ------MIWSI-RHF-------------RL-------------------TWEQ------------------V-PSKHLNS 382  Pristionchus ...
WP_011727486  262 ------WIEIIgRGH-------------GL-------------------SWEM------------------L-PDAALAQ 284  Mycobacterium...
ERG85813      429 ------AASLI-REY-------------GL-------------------VREH------------------V-PSHLLNS 450  pig roundworm
XP_005341459  439 ------VQALLGYRYpsnlq---lfsrsGLpgpwdssragkrmklsrpeTWER------------------E-LSLRGNK 490  thirteen-line...

Q231I6        363 AEVWDNLISSnQLPYMAMLRNLSNILKAGVSD-TT-----H-----S---IVINKICEPKAVENSKMFPLQFFSAIEavn 428  Tetrahymena t...
Q27274        371 KLVWETLFDV-SMPMTAMIRNLAKMTVVGALD-EK-----R-----Vd--NIVKRLTDQEELRRSRIHPINLLTARa--- 433  Caenorhabditi...
EGT55430      365 KLVWETLYDV-RMPMTAMIRNLAKMTVVDALD-EK-----R-----Vd--DIVKRLTNQDELRRARIHPLNLLTARA--- 427  Caenorhabditi...
XP_003373098  311 KHIWQALLK--EMPLTATVRTLNRMTVAGLLI-PG-----S-----EatnLVVERLNDTEALRAARVHPMALLLAYV--- 374  Trichinella s...
XP_011456874  298 KEIWKALIK--FMPMTAMIRNLGKMSQLELLE-PGs---fE-----En--LTISKLTNPEMLTRARIHPFTLLVALN--- 361  Pacific oyster
XP_001698480  300 PAVWGAFLEN-GMPLTAMIRNLGRMSELGVLEqPG-----Y-----Qq--RVTDRLRDAKALTAARVHPMTLLDAMC--- 363  Chlamydomonas...
KKA65036      383 LEVWKAIVE--RMPMLAMIRNLAKMQNVGLFK-GE-----KkegdkIa--HVVAHLANIEAIKKARIHPIQILLAKT--- 449  Pristionchus ...
WP_011727486  285 PAVWEALIDR-GMPQTALMRQLPRLTRLGVLS-GA-----V-----Gd--TVAEQLADRDRLVKARVHPVNVLVAQR--- 347  Mycobacterium...
ERG85813      451 KSVWDALLV--DMPMTALIRNLGKLASIDMIT-DKeenkrH-----Vq--KVVSQLTDEQALQDARVHPVSVLLASa--- 517  pig roundworm
XP_005341459  491 ASVWEELIDNgKLPFMAMLRNLCNLLRVGISA-RH-----H-----G---LILQRLQHEKSVINSRQFPFRFLNAHDsid 556  thirteen-line...

Q231I6        429 eavtkgfkakkrenmnlkgqieavkevvektdeekkD------------------------MELEQTEEGEFV-KV---- 479  Tetrahymena t...
Q27274        434 ------------------------------------------------------------vYAQGRGDKGSltw-----e 448  Caenorhabditi...
EGT55430      428 ------------------------------------V------------------------YAQGRGDKGSLKwEP---- 443  Caenorhabditi...
XP_003373098  375 ------------------------------------N------------------------YKEGRTSHSRLRwDP---- 390  Trichinella s...
XP_011456874  362 ------------------------------------Q------------------------YKKGQGELGSLKwQT---- 377  Pacific oyster
XP_001698480  364 ------------------------------------T------------------------YRNGAGARGKARwAP---- 379  Chlamydomonas...
KKA65036      450 ------------------------------------V------------------------YDVGTGDRGSLTwTP---- 465  Pristionchus ...
WP_011727486  348 ------------------------------------T------------------------YTRGCGARGQAVwTP---- 363  Mycobacterium...
ERG85813      518 ------------------------------------------------------------vYKSGGGYRGKlhw-----k 532  pig roundworm
XP_005341459  557 nleaqlrnralpfps----ninlmrrimirkskkvrRparwkhlcklsrrelraamkipaiYEELQREKLKIH-KArqgn 631  thirteen-line...

Q231I6        480 -NEGIgkqyINSIELAIKIAVNkNLDEIKG 508  Tetrahymena thermophila SB210
Q27274        449 pNQKI----CDALEAGFYKAFV-NAPPTGK 473  Caenorhabditis elegans
EGT55430      444 -NQKI----VKALEDGFYKAFV-NAPPTGK 467  Caenorhabditis brenneri
XP_003373098  391 -EPTV----VAALERAFYHSFG-NVLPTGK 414  Trichinella spiralis
XP_011456874  378 -NDNI----SKALEDAFYMSFK-NVKPTGK 401  Pacific oyster
XP_001698480  380 -VAAV----TAALEDAFYLAFK-NVVPTGK 403  Chlamydomonas reinhardtii
KKA65036      466 -KPEL----SAALEKAFYLAFS-LMPKTEK 489  Pristionchus pacificus
WP_011727486  364 -VAKI----SDALDAAFYAAYG-AVRPAYK 387  Mycobacterium smegmatis
ERG85813      533 tNPEI----TAALEKAFLLAFK-NVTPTNK 557  pig roundworm
XP_005341459  632 yDLEIldqyRQALEAAVNLSVKhSLPPLPG 661  thirteen-lined ground squirrel
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