Conserved Protein Domain Family
eIF_4EBP
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pfam05456: eIF_4EBP (this model, PSSM-Id:283183 is obsolete and has been replaced by 461656)
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.
Links
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Statistics
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PSSM-Id: 283183
Aligned: 45 rows
Threshold Bit Score: 110.357
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q60876        11 PSRAIP--TRRVALGDGVQLPPgDYSTTPGGTLFSTTPG---------GTRIIYDRKFLMECRNSPVAKTPP----KD-L 74  house mouse
Q7PN41        14 ISQAIP--SKRVLIHDASELPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPP----NN-- 75  Anopheles gambi...
Q17JZ5        13 QTQAIP--SKRVLIHDASELPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPP----SN-L 75  yellow fever mo...
XP_011066562  12 QSQSIP--SKRIVIHDPNQLPV-DYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLRNSPISRTPP----RN-P 74  Panamanian leaf...
XP_001604271  12 QTQSIP--AKKVVIHDANQLPA-DYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLRNSPISQTPP----KN-M 74  jewel wasp
XP_001846418  10 aAMTIP--SRKVLIHDASDLPD-LYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPP----TN-L 72  southern house ...
ETN61553      14 ITQAIP--SKRVLIHDASELPD-LYSSTPGGTLYSTTPGasrpssggpSTRIVYERAFLMNLKNSPLARTPP----NN-V 85  Anopheles darlingi
XP_974931     12 ESKAIP--TKKVLINDPSELPS-HYSSTPGGTLYSTTPG---------GTKIVYEKAFLMNLRNSPISKTPP----SY-G 74  red flour beetle
NP_001040409  12 HSQSIP--SRRVLITDPAQMPD-VYSSTPGGTIYSTTPG---------GTRIVYERSFMLSLRQSPISQTPP----QCaL 75  domestic silkworm
XP_004362536  11 TSRAIPfnVSRQDM-------I-NFSTSLGGTLYGTTPG---------GTKLVYDKNTLLQYRNSPLAKTPPppemAN-M 72  Dictyostelium f...

Q60876        75 P--------AIP------G-V---TS--P-TSD------E-PPMQASQSQLPSSPEDKR-AGG--EESQFEMDI 117 house mouse
Q7PN41        76 ----------VPmnllrtG-V---VS--P-NTK------PmTTLSVKQQKPARNSPPKY-DEH--QE-QFDMDL 122 Anopheles gambiae str...
Q17JZ5        76 N--------NLPhni-lrN-G---TT--G-VTS------K-----PKPQQQPQNSPPKF-DEH--QE-QFDMDL 118 yellow fever mosquito
XP_011066562  75 L--------TIPsel-lkG-N---TP--V-ITK------D-------PAKNTNKDSLMI-EES--AE-QFEMDM 115 Panamanian leafcutter...
XP_001604271  75 P--------TIP------AsL---LK--G-AAP------T-VTAPNKIPSPPAKDAAVL-DES--AE-QFEMDM 117 jewel wasp
XP_001846418  73 N--------NLP------H-NilrNS--PtANR------Q-QQHVPQAKKQP-NAQPKF-DEH--QE-QFDMDL 117 southern house mosquito
ETN61553      86 PlnllrangSPT------G-G---ASakP-LST------L-SLSKPNQQKPARNSPPKY-DEH--QE-QFDMDL 137 Anopheles darlingi
XP_974931     75 ----------IPenl-mrG-K---TN--G-SAP------I-----RRFSPPTKNHSAKIeDSH--DEHQFQIDI 117 red flour beetle
NP_001040409  76 P--------A--------A-L---LK--N-PSS------V-PNVQPASTQKPRSNSISF-DES--QE-TFSMDL 115 domestic silkworm
XP_004362536  73 L--------N--------M-I---NK--S-QSSphphskP-IHSNKQPAAASTSAEAKN-TTKqnEDDIFEMD- 120 Dictyostelium fascicu...
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