4LT6,1FA0


Conserved Protein Domain Family
PAP_central

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pfam04928: PAP_central (this model, PSSM-Id:282745 is obsolete and has been replaced by 461486)
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Poly(A) polymerase central domain
The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.
Statistics
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PSSM-Id: 282745
Aligned: 119 rows
Threshold Bit Score: 346.385
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LT6_A        26 GITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEelnhrlvVLGKLNNLVKEWISDVSE-Sknlp-psvVATVGGKIF 103 human
Q4E647         6 GPTKPLEVPPAQPRDLAESKRLCETMATVVADRVRE-------AIDLIELTAHRLVDQITA-E--------PEERWVRAY 69  Trypanosoma cruzi
XP_010314830  19 GVTKPLSLAGPTETDLQRNAELEKFLRESELYESEEetarreeVLRRLDQIVKQWVKQLTR-Qrgyi-dqmVEDANAIIV 96  tomato
XP_001752191   8 GVTEPISTADPTEVDYVNTKQLEECVKGLALQGSREeevrreeVLGRLDELVNVWVKSMSR-Kkgln-deyVREARCKIF 85  Physcomitrella ...
XP_002280350  12 GLTKPISYVKPTDFHIRRSFELEKVLWDGGVYQVEEearkreeIIEKLRVVVKSWVKQVTR-Wkgyt-dkmVENANALIV 89  wine grape
XP_002515957  18 GVTKPISTAGPTEADIQRTRELEKLLGDSGLYESKDeavkreeVLARIDQ------------------------------ 67  castor bean
XP_002140497  25 GVTPPISESLPTPQDYKLTEQLIIAMRSENLYETVEgmkkreqILASLNKMVREWIYEASL-Ehsms-eeeSLTAGGGIY 102 Cryptosporidium...
XP_001608755  14 GITDPVSTDGPSESDREDTAELMKFLVAQNLFETEDgkrkrerVLESLNRVLQQFVRKNAI-KqlgipddeASKISAKLL 92  Babesia bovis T2Bo
XP_002773978  13 GVSPPVSLSKATPKDIAATDVMMKVLDEEAPPASEEerqlhkrVFELMSRLVTEWGKEYAF-Stgl----keEDCRCELM 87  Perkinsus marin...
Q4N9S7        14 GITDPVSHEGPTNNDLKASRELLNLLKSHNLYETEEgkkrredILESLNRLLQQFVRRQAKiTrglt-dqeASQVSGKLL 92  Theileria parva
4LT6_A       104 TFGSYRLGVHTKGADIDALCVAPRHVERS-DFFQSFFEKLKHqdGIRN--LRAvedAFVPVIKFEFDGIEIDLVFARLAI 180 human
Q4E647        70 PFGSCGLGASVADSDLDIVLFCSFKVTAE-VFFREFPPLLQP--VVGNvvLVP---ARVPVVKFSYSGTSVDVVFVSAAL 143 Trypanosoma cruzi
XP_010314830  97 TFGSYRLGVHGPGADLDTLCVGPCYVNREeDFFILLHDILAEmeEVCE--LQPvpdAHVPVMKFKFQGISIDLLYASITL 174 tomato
XP_001752191  86 TFGSYRLGVHGPGADIDTLCVGPCYVTREeDFFVELHDLLQKteGVTE--LHTvpdAHVPVMSFEFNGIPIDLLYARLPL 163 Physcomitrella ...
XP_002280350  90 TFGSYRLGVHGPGSDIDTLCIGPSYVNREeDFFIRLHNILIGmeGVSE--LLPiphAHVPVMKFKFEGVSIDLLYASVSH 167 wine grape
XP_002515957  68 --------VHGPGADIDTLCVGPSYVNREeDFFFVLHNILAEmeEVTE--LQPvpdAHVPVMRFKFDGISIDLLYASISL 137 castor bean
XP_002140497 103 TFGSYRLGVVAAGSDIDTLCIVPRHITRD-SFFTFFLAKLQQdiHITK--IQPvpdAYTPIIKMVYYGIEMDLLFACLNL 179 Cryptosporidium...
XP_001608755  93 TFGSYRLGIVAPNSDIDCLCLCPQSVTRE-SFFTDFYNALKLlpNITK--LHAvpdAYTPVIKLIYDGIDIDLLFANLPA 169 Babesia bovis T2Bo
XP_002773978  88 AIGSARLGLQDPSSDIDCVVVAAHKVTRD-AFFELFPLKLSElnDVTN--LNPvpqAAVPVIKMKFMGVDVDVLYCGLAH 164 Perkinsus marin...
Q4N9S7        93 TFGSYRLGIVAPDSDIDVLCLCPRSVTRE-SFFSDFYNTLNKvdGISK--LQAvpdAYTPVIKLYFYDISIDILFANLDA 169 Theileria parva
4LT6_A       181 QTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKE-TFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVA 259 human
Q4E647       144 AAPPTTEQLLDDSFLLQVARDTRHSVNGLRTVLEVKRRLPVAYdVFTTVLKSVKLWAMRRKVYGNLYCYPSGVVLAIMVA 223 Trypanosoma cruzi
XP_010314830 175 LVIPEDLDISDQSVLCNVDGPTVRSLNGCRVADRILKLVPNAK-HFRTTLRCLKFWAKRRCVYSNVTGFLGGVNWALLVA 253 tomato
XP_001752191 164 WVIPEELDILQDTILQNVDEQSVRSLNGCRVTDRILRLVPNME-HFRTTLRYVKLWAKRRGVYSNVIGFLGGVNWALLVA 242 Physcomitrella ...
XP_002280350 168 LVVPDDLDISNESILYEADEPTVRSLSGCRVADQILRLVPNVE-HFRTTLRCLKFWAKRRGVYSNVTGFLGGVNLALLVA 246 wine grape
XP_002515957 138 LVVPEDLDISDVSVLYDVDEPTVRSLNGCRVADQILKLVPNVE-HFRTTLRCLKFWAKRRGVYSNVTGFLGGVNWALLVA 216 castor bean
XP_002140497 180 SRIPSDLNTLDDDLLRNVDEKTARSLNGCRVNDMILQLVPNKE-SFRTALRFVKHWSKSRGIYSNVLGYLGGISWAILTA 258 Cryptosporidium...
XP_001608755 170 QTVPEEIDVLDDAILRNMNEATARSINGCRVAALILASVPNKD-NFRTTLRYVKLWANRRGLYTTVMAYMGGVAWAILTA 248 Babesia bovis T2Bo
XP_002773978 165 PLSGPAIDPADDNLLCGMDEKSARSINGVRVSDAIKACVPHFA-HFLGALRVIRAWARRRGIYSNALGYLGGVSWAILVA 243 Perkinsus marin...
Q4N9S7       170 PTVSPHINVLDDNILRNMNDSTVRSINGCRVASYILDSVPNKN-YFRTTLRFIKLWASRRKIYSTVVGYLGGVAWAILTA 248 Theileria parva
4LT6_A       260 RTCQLYPNAAASTLVHKFFLVFSKWEW---PN-P--VLLKQPEES--N---Ln-Lp----VWD--PrVNPSDR-----YH 316 human
Q4E647       224 RICQVMPASHPNVLLRFFFLFYTQWLSrhdRIsP--VYITTSLES--RgriP--Glp--dSWD--P-RRDACR-----DD 287 Trypanosoma cruzi
XP_010314830 254 RICQFYPNAIPSMLVSRFFRVYTQWRW---PN-P--VMLCPIEED--El--Gf-L-----VWD--PrKNPKDR-----TH 310 tomato
XP_001752191 243 RICQLYPNAVPSVLLSRFFRVYKQWRW---PN-P--VMLCAIEEGp-----Lg-Lp----VWD--PrRNPRDR-----SH 299 Physcomitrella ...
XP_002280350 247 RVCQLYPNANPSMLVSRFFRVYTQWHW---PN-P--VMLCPIED---Ke--Lg-Fp----VWD--PrRNPLDR-----NH 303 wine grape
XP_002515957 217 RICQLYPNAIPSMLVSRFFRVYTQWRW---PN-P--VMLCPIEED--El--Gf------sIWD--PrKNPRDR-----TH 273 castor bean
XP_002140497 259 RICQLYPNSAPNQIINRFFYVYKAWQW---KN-P--VILCEIKEVpkNs--Pg-Lmg-frVWN--PnTNPQDR-----AH 321 Cryptosporidium...
XP_001608755 249 RVCQLYPNFLPNQLIQKFFRVYAQWNW---KC-P--VMLCKIKEV--Pn--Ip-GymsfkVWD--PrNNPTDR-----QH 310 Babesia bovis T2Bo
XP_002773978 244 RVCQLFPNMGPSQLVVRFFRVYSRWNWd--PS-EgaVVLRHSEQR--Ng--Eg-Fqh-hkVWCppPkRTTTDQplplaAS 314 Perkinsus marin...
Q4N9S7       249 RVCQLYPNCAPNQLIEKFFRVYSVWQW---EC-P--VTLCKIKEP--Pn-iPglMsf--kVWD--PrVNPQDR-----HH 310 Theileria parva
4LT6_A       317 LMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVT--D----EILQgKsdWSKLLEP 369 human
Q4E647       288 LLPVINPAYPYVNDARNVGRCSLEVFYAELTYAYRLL--S----NLET-P--LEAIWEP 337 Trypanosoma cruzi
XP_010314830 311 HMPIITPAYPCMNSSYNVSPSTLRVMMDQFQIGNKIS--E----DVELnKsqWPALFEh 363 tomato
XP_001752191 300 LMPIITPTYPCQNSSFNVSNSTLRVMTEEFKRGDSIC--D----SLDSkVadWSKLFEP 352 Physcomitrella patens
XP_002280350 304 HMPIITPAYPNMNSSYSVSTSTLEAMMKQFHTANKIC--N----DIELnKssWGALFEP 356 wine grape
XP_002515957 274 HMPIITPAYPCMNSSYNVSTSTLRVMMEQFQYGNKIC--E----EIELiKtqWATLFEP 326 castor bean
XP_002140497 322 LMPIITPAFPSMNSTHNVTQTTLRVITEELQRGSELV--K----EIENeRaqWSDLWSP 374 Cryptosporidium muris RN66
XP_001608755 311 LMPVITPAFPSMNSTHNITLTTKRILTDEFKRANDLL-------KVNAkGaqMKNIWER 362 Babesia bovis T2Bo
XP_002773978 315 PMAVITPAYPSMNSTFGVTRMTMDTIKKELERGAGII--SskgvDLRSrEc-WETLLEP 370 Perkinsus marinus ATCC 50983
Q4N9S7       311 LMPIITPAFPSMNSTHNVTATTKRVITEELMRALEIFktS----NLTNvEl-WEKVLEE 364 Theileria parva
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