3K2I


Conserved Protein Domain Family
Bile_Hydr_Trans
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pfam04775: Bile_Hydr_Trans (this model, PSSM-Id:282610 is obsolete and has been replaced by 461422)
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Acyl-CoA thioester hydrolase/BAAT N-terminal region
This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolizm. For example, in peroxisomes, the hydrolase acts on bile-CoA esters.
Links
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Statistics
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PSSM-Id: 282610
Aligned: 147 rows
Threshold Bit Score: 69.8702
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3K2I_A        18 EPVRIAVRGLAPEQRVTLRASLRDe---------KGAL-FRAHARYCADACGELDLERAPALGGSFAGLEPM--GLLWAL 85  human
Q8DV73        16 SPFELIIERLPPCCQVKVRLDLDHyyninapmnlSSQApWQAEALFYSDDKGILDLSE----SNPYHNLSIM--ELFFKS 89  Streptococcus m...
WP_044955858  34 EAVTIRVSGLRAGEKVTVTAETDDa---------GGVT-WTGRATFTADRTGAVDPARAKPSAGTYRAADAM--GLFWSM 101 Streptomyces cl...
WP_009945491  38 EPLRVAVSGLEPGSTATVWARMTDd---------QGRP-WTSWGVFAADGTGRVDLARQAPTGGSYSGTEPE--GLLWSM 105 Saccharopolyspo...
WP_012921729  17 TPLQIRVNGLPPGAETVLTATQPDq---------TARP-WTSSATFVAGPSGELDLSTDAPIAG-YAGADPM--GLVWSM 83  Kribbella flavida
WP_033260076  43 QAVHVRIGGLRPGEEVTVGTRALDd---------QGRV-WSGRAVLRADGGGLVALDTAVPRSGSYQEADGM--GLFWSM 110 Kitasatospora s...
ACY12843      54 APMDIRLAGLEPGERVTVRATMADs---------PELI-WQASAVFAADAAGTVDLGRDAPLEGSYESADAM--GLIWSM 121 Haliangium ochr...
AFD24464      19 rrffLRAWALPPKTEVTVGTAAPDr---------HGAC-WQAEATYRTTAAGALDLSAQPALTGRFRGVDPA--GPIWSL 86  Deinococcus gob...
WP_013808643 229 TPFPVRVEGCASGAEVRIQTNGTDl---------FGRK-WRSAAVFTAPVAGPLDLASAAPVSGDWAVADGD--APIWAM 296 Amycolicicoccus...
WP_013487962  14 EPLQLHMDGLKPNETITLTLKMKYe---------Q-VM-WTSTTTTAADDNGKL------SI-GSADGKSNIlsELLWKM 75  Bacillus cellul...

3K2I_A        86 epek------pfwRFLKRDV-Qi-PFv--VELEVLdghdpeP---GRLLCQAQHERHfLPPGVWRQ 138 human
Q8DV73        90 qpivc---kkaklSQQLESI-Pl-NPfydLKISIFk-----G---HSLLGETSVRRYyQLPSISCL 142 Streptococcus mutans
WP_044955858 102 epeqg----saaaSVFVSDV-Lq-Rp--vDTVRVTar---aE---GRPDAHRDLARRwTAEGVEsr 153 Streptomyces clavuligerus
WP_009945491 106 rlpdgapatdprpALDSGEV-A---------YTVGvd---vA---GRTVARDSLVRRlRAPGVRsl 155 Saccharopolyspora erythraea
WP_012921729  84 trgr-----kprgAERDRRL-Lp-Pa--eLTLSVEat---vPaagGRFSASAVVQRHrWPDGVRRa 137 Kribbella flavida
WP_033260076 111 apad-----gdpeRLSFTPP-LsaDh--aYRLTLTas---aP---GRRSADLVLTRQwYGPGVTgr 162 Kitasatospora setae
ACY12843     122 tpsted--weqhaRAAPQ---Lq-Pm--rIRYEAErt---gA---DKVFAAVDVERLrIAEDVRRs 173 Haliangium ochraceum DSM 14365
AFD24464      87 rprp-----dhtpAFFEAPE-Ag------VTLTVRls---aG---ERVLEETTVRRLtHSPDLHet 134 Deinococcus gobiensis I-0
WP_013808643 297 rsap-----aeglSGMFVAP-Ag-Dw--lVTVEATsg---------nAVVRRTVVRHaAPSSVTvs 344 Amycolicicoccus subflavus
WP_013487962  76 hpqsk----qqhkSLFNEDIsQl-Tl--hIDIEAe------E---SQRKEARTITRMfKEDYVHee 125 Bacillus cellulosilyticus
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