Conserved Protein Domain Family
Pinin_SDK_N
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pfam04697: Pinin_SDK_N (this model, PSSM-Id:282542 is obsolete and has been replaced by 461397)
pinin/SDK conserved region
SDK2/3 is localized in nuclear speckles where as pinin is known to localize at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing. pinin has also been implicated as a tumour suppressor. The conserved region is found at the N-terminus of the member proteins.
Links
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Statistics
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PSSM-Id: 282542
Aligned: 5 rows
Threshold Bit Score: 116.121
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011420191   7 VSALQNEIEKARENLKGVDENIKKLTGRDPTERRQFAp----KRRVVSvSGELrgKERLFSQARREIE---AyVSPVKRR 79  Pacific oyster
XP_012867687   5 VRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQa----RLLALSgPGGG--RGRGSLLLRRGFSdsgG-GPPAKQR 77  Ord's kangaroo rat
AAH95809      14 VRSLQDQLEKAKEGLKSVDENIRKLTGRDPGELRPGQn----RRLTIPgPGGG--RGRGINLLRRGLSdsgG-GPPAKLR 86  zebrafish
XP_002610726   5 VRSLQDQINKAKENLKGVDENIKKLIGRDPSDNRPGAvggpgRRVSLGgAGPGvgRGRGAGFRRESEDw--GdGPAVKRR 82  Florida lancelet
XP_002124629   5 VSALKEQIERAKENLKTVDDSIKKVTGRDPNEARP----------ERQmNERGrgRGRGQVLGRRRWTnegAeEPPSKKA 74  vase tunicate

XP_011420191  80 -VVG-T------AFSR--LGPpRLAGRDRQRADSGDEEDlPNKPAVQSSVgnVITSKTPrSRKESMDNQ 138 Pacific oyster
XP_012867687  78 -DLE-G------AVSR--LGGeRRTRRESRQESDPEDDD-VKKPALQSSV--VATSKER-TRRDLIQDQ 132 Ord's kangaroo rat
AAH95809      87 -DID-G------ALLR--LAGdQRARRDSRHDSDAEDDDdVKKPALQSSV--VATSKER-TRRDLIQDQ 142 zebrafish
XP_002610726  83 gEIGlG------ARDRrvVTYrGRGRGRGRRDDEDDEDElPHKPSLASSV--IPTPTAKmTRKDSIDql 143 Florida lancelet
XP_002124629  75 gDLY-QrvgvgpGRRV--VAGnRRNFAPVAHHESEEEEEeEQKLTVQSSI--VSTAKKI-TKKELIHAQ 137 vase tunicate
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