Conserved Protein Domain Family
TPD52
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pfam04201: TPD52 (this model, PSSM-Id:282107 is obsolete and has been replaced by 461225)
Tumour protein D52 family
The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.
Links
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Statistics
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PSSM-Id: 282107
Aligned: 22 rows
Threshold Bit Score: 165.687
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3SYU8        20 DSMTDVPVDTAVAAQAPAv-eGLTETEAEELRAELAKVEEEIVTLRQVLAAKERHCGELKRKLGLSTLEGLKQNLSRSWH 98  cattle
XP_007484569  18 DPLHEPVEETISHIDLNS----ISEEEREELKTELVKLEDEISTLPQVLTAKEKHLVEIKQKLGMNLMNEIKQNFSKGWH 93  gray short-tail...
XP_006635694  52 EPIPEVGEDAVSTVSLSAp--ALTEEEQEELRAELAKVEDEIQTLSQVLAAKEKHVAEIKRKLGISPLNELKQNITKGWQ 129 spotted gar
XP_007255464  33 EPLQEVDEEMVSEVDLNN---TITEEEKEEMHNELTKLEEEIATLRQVLSSKEKRHSELKQRLGITPLSELRHNLSRGWN 109 Mexican tetra
XP_007656188  62 EPLQGANEGRSSEIVFLS---MISEEEREELKTELVKLEEEVSTLRQVLSAKEKHRLEIKQKLGMTLMDELRQNLSKGWH 138 platypus
XP_003269527  52 DPVPEEGEDVAATISATEt--L-SEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQ 128 northern white-...
XP_011610284  45 GPLKETDEDSGSEVNLNSs--IMTEEEREEILQELAKLEEEIGTLRQVLSSKEKQHADLRQKLGINPLNEIRSNFNRGWR 122 torafugu
XP_007249368  47 DSIPEVGEDAVTTVGETTpstALTEEEQEELRNELIKVEEEIQTLSQVLASKEKQVAEIKRKLGITPLNELRQNLSKSWQ 126 Mexican tetra
XP_002936056  13 QPLQETDEELATDIDYSE---TISEEEKEELKSELFKLENEIVTLRQVLAAKEKHLVEIKQKLGVSMMNELKQNFSRSWH 89  western clawed ...
XP_006626511 245 EPLQEVDEDVVAEVDLNNs--V-SEEEREEIQTELAKLEEEIAALKQVLAAKEKHHAELKLKLGMNPLNDLKQNVSKSWH 321 spotted gar

Q3SYU8        99 DMQVSNAYkktqetlsqagQKTSAALSTMGSAISRKLGD-----------------------MRNSATFKSFEDRVG--- 152 cattle
XP_007484569  94 EMQTTTAYkkthetlshagQKATAAFTNVGTAISKKFGD-----------------------MRNSPTFRSFEERVEttv 150 gray short-tail...
XP_006635694 130 DMTASTAYkktsetlsqagQKATAAFSSVGSAITKKLEDvrlqafsnsfsirslqhsismpaMRNSPTFKSFEEKVE--- 206 spotted gar
XP_007255464 110 DMQTSTAYkktsetlstagQKTTAAFSNLGSAISRKFGDmstqpsysi------rhsvsmptMRNSPSFKSFEEKVEntv 183 Mexican tetra
XP_007656188 139 DVQTTSAYkkthetlsqagLKATAALNNMGMAISRTFGD-----------------------MRNSSTFKSFEERVE--- 192 platypus
XP_003269527 129 DMTATSAYkktsetlsqagQKASAAFSSVGSVITKKLEDvklqafshsfsirsiqhsismpaMRNSPTFKSFEEKVE--- 205 northern white-...
XP_011610284 123 DVQTSVAYkktsetlstagQKTSAAFSTLSSTISRKFED-----------------------MRNSPSFRSLEEKMEntv 179 torafugu
XP_007249368 127 EVTTSTAYrrtsetlsqagQKATATFTSVGSAISRKLEDvsirsiq---------hstsmpvMRNTPTFKSFEDRVE--- 194 Mexican tetra
XP_002936056  90 DVQTHSAYkktqetlsqagLKATAAITNVGSAIGKKLGDmrshsisys-----irhsismpaMRNSPTFKSFEERVE--- 161 western clawed ...
XP_006626511 322 EVQTSTAYkktqetlstagQKATAALSNVGTAISRKFGDmrshsigys-----irhsmsmpaMRNSPSFRSFEEKVEstv 396 spotted gar

Q3SYU8       153 -Ti----kSKV--VGGREn---gGDNLPSPTGSGD 177 cattle
XP_007484569 151 tNl----kTKV--GGIPMgg-nfEEVLsstahasa 178 gray short-tailed opossum
XP_006635694 207 -Tl----kTKV--SSQPPtg-dfGEVLNsaasasa 233 spotted gar
XP_007255464 184 tNi----kSKV--GGTSSgg-sfEEVLSSAAQASA 211 Mexican tetra
XP_007656188 193 -TtvtslkTKVggAGGSSgg-sfEEVLsstaqass 225 platypus
XP_003269527 206 -Nl----kSKV--GGTKPaggdfGEVLNSAANASA 233 northern white-cheeked gibbon
XP_011610284 180 sNi----kTKV--GASESkg-nfEEVLssaasass 207 torafugu
XP_007249368 195 -Si----kTKM--SPTPSts-elGDVSNSIPNAES 221 Mexican tetra
XP_002936056 162 -NtvttlrAKV--GSANQtqgsfEEVLSSTAHASA 193 western clawed frog
XP_006626511 397 sTl----kTKVg-GSSSSrg-sfEEVLSSTAHASA 425 spotted gar
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