Conserved Protein Domain Family
Paf1
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pfam03985: Paf1 (this model, PSSM-Id:281915 is obsolete and has been replaced by 397885)
Paf1
Members of this family are components of the RNA polymerase II associated Paf1 complex. The Paf1 complex functions during the elongation phase of transcription in conjunction with Spt4-Spt5 and Spt16-Pob3i.
Links
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Statistics
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PSSM-Id: 281915
Aligned: 38 rows
Threshold Bit Score: 250.337
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17LJ8        27 ELISRVKYCNTLPDIPFDLKFITYPFE---NDRFIQYK-PTSLERNYRYEVL-------TEHDLGVTIDLINRDLYQI-D 94  yellow fever mo...
Q9US06         7 DYILRVRYHNPLPPPPFPPKLINIPNP---VKQYALPNfVSTLVQEKKIPIE-------NDIELGMPLDLAGITGFFEgD 76  Schizosaccharom...
EHK48006      16 DFIARIRFSNALPPPPNPPKLLDIPNTglaSGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgD 88  Trichoderma atr...
ETS06374      15 DFIARIRFSNALPPPPNPPKLLDIPNTglaSGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgD 87  Trichoderma ree...
CCE27944      16 DFIARIRFSNALPPPPNPPKLLDIPNTglaSGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgD 88  Claviceps purpu...
EPY53462       7 DYILRVRYHNPLPPPPFPPRLINISNP---VKQYALPNfVSNLIQEKKIAIE-------NDAELGMPMDLAAVDGFFEgD 76  Schizosaccharom...
XP_003954938   6 DYIAKIRYENNLPPPTVPPKLLNYQIN---PDEDVD---SPQLITSLYTRTNvtp-lvdINGDLGMPMDLMEIPGLLNkN 78  Kazachstania af...
XP_001560890  12 EYIARIRYSNALPPPPNPPKLLDIPNTglaSGQYTTPGfATRLARDQPLNIE-------ADAELGMPLDLVGMPGIFDgD 84  Botryotinia fuc...
XP_001525872   9 DYIAKIRYTNNLPPPPLNPKYIEYNTT---NPISPKVE-AEQLLSSLFRKENfqnllgrIDDFSGLELNLLNNAGFFAgD 84  Lodderomyces el...
XP_004199563  11 EYISKVRYINDLPPPPLNPKFLEYNTT---ERSSTKTE-SEQVISSLFRKENfhsliecIDEDMGMNLNLLNNKGFLDeN 86  Pichia farinosa...

Q17LJ8        95 ------H-------------L---------AQLDPADEKLLEEDihtpQDSLRSSrHAKSVSWLRKSEYISTE-QT-RFQ 144 yellow fever mo...
Q9US06        77 t----sW-------------Mhsd---lssVNLDPIDRSLLKVAggs-------gsTHLEVPFLRRTEYISSE------- 122 Schizosaccharom...
EHK48006      89 e----rS-------------Iqap---sqpLAVHPHDRALLRPI----AALGKPKvAEANVSFLRRTEYISSL-IP-KRF 142 Trichoderma atr...
ETS06374      88 e----rS-------------Iqas---sqpPPVHPHDRALLRPI----AALGKPKvAEANVSFLRRTEYISSL-MP-KRL 141 Trichoderma ree...
CCE27944      89 ersiqaP-------------Vq-------tPAVHPHDRPLLRPI----AALGKPKvAEANVSFLRRTEYISST-TP-KRL 142 Claviceps purpu...
EPY53462      77 t----sW-------------Nqsd---msgMNLEPVDRSLLKVAg-------gSGsSHVEVPFLRRTEYISAE-VG-R-- 125 Schizosaccharom...
XP_003954938  79 d----tR-------------Ylys---fdnVKLDPKDRILLRDp----RVDRLTKtDMSKVKFLRRTEYVSST-IA-ASN 132 Kazachstania af...
XP_001560890  85 e----sS-------------Iqap---lhpPQLHPHDRALLRPl----ATLGKPKfSDTGVSFLRRTEYISSG-FTsKAR 139 Botryotinia fuc...
XP_001525872  85 s----tV-------------VgqlskngqpVHLHPKDRALLRDAgigkINK-----SEPGVSFLRRTEYISERsLP-KAA 141 Lodderomyces el...
XP_004199563  87 d----eSvigmflneknkkdNk-------pVTLHERDRELLRDA----GIERIAR-SELGVSFLRRTEYISEKqFM-KPS 149 Pichia farinosa...

Q17LJ8       145 PQTM-EKVE-AKVGFNVKQsl----rEETLYMDREAQIKA-IEKTFDDNTKEIT-----AHYSKPGVTPVEILPVFPDFA 212 yellow fever mo...
Q9US06       123 -VARaASNR-GNLRLTASTskalaeqRGRSLREVPKQLEA-INESFDVVQQPLEq---lKHPTKPDLKPVSAWNLLPNTS 196 Schizosaccharom...
EHK48006     143 --EA-NHPR-ALLAKSRRPv-----kRPEPAADSPQAIKRkIDKGFEVAEQDLKdpkriKHPSKKHLKLVDALPLVPDLD 213 Trichoderma atr...
ETS06374     142 --EA-NHPR-ALLAKNRRPa-----kRPEPAADSPQVIKRkIDKSFEIAEQDLKdpkrvKHPSKKHLKLVDAAPLLPDLD 212 Trichoderma ree...
CCE27944     143 --DA-SHPR-ALLPKARRPlr----tAPDAAADSPLAIKRkIDRSFETAEQDIKdvkrvKHPTKKHLKVVEAIPMLPDLE 214 Claviceps purpu...
EPY53462     126 ---N-SSTR-GNLRLTASTskaiaeqRGRSLREIPNQIQA-IEQTFSAVQQPLEn---lKHPTKPELKPVGAWNFLPNDS 196 Schizosaccharom...
XP_003954938 133 TKKR-PRNRle--------------dDDDKVLNPAEIVTR-VENTFEAMTDDLSk---lRHPVKRHLKATKVWNLIPDTA 193 Kazachstania af...
XP_001560890 140 MEGT-TSAK-GLVDTRKPKpv----qNLPADRESPAYIKAqVEKGFETAAANLKdrtrvRHPTKRNVQLVNAVPLIPDLD 213 Botryotinia fuc...
XP_001525872 142 HSVT-AHTEeVKVNEKLKNn-------ESHSLDADAQLNA-VEETFTAANSTLLdvsslKHPRKRHLKAVDAWPLLPDTQ 212 Lodderomyces el...
XP_004199563 150 ANGV-ENG-----AHKLTKgk----eDNQEKLDADAQLQA-VEKTFADAQKTLQdfqniKHPRRKNLKAVAAWPILPDTS 218 Pichia farinosa...

Q17LJ8       213 NWKYP--CAQVIFDFDPAP----AGKNVPA--------Q-----MEEMSQAMIR----------------------Gv-- 249 yellow fever mo...
Q9US06       197 MAGIQ--HLMLRVADDLSErshsYSSLVNL--------QeghnlTKRHEVALFM----------------------P--- 241 Schizosaccharom...
EHK48006     214 AFPDSgaYVTIKFLTNPVSssneYD--------------------NRLRSGLFRpidrtaaeeaaleaameaynqdPv-- 271 Trichoderma atr...
ETS06374     213 AFPDSgaYVTIKFLTNPVSssseYD--------------------TRLRSGLFR----------------------Pidr 250 Trichoderma ree...
CCE27944     215 AFPDSgaYVTIKFLTNPVSsaneYD--------------------TRLLSGLFR----------------------Pier 252 Claviceps purpu...
EPY53462     197 MAGIQ--HLMLRVSDNLTDrtptSSTPGEE--------Dv----SNRHKVALFM----------------------P--- 237 Schizosaccharom...
XP_003954938 194 SMDQN--YFTLKLVGSAALdkreKEAL-------------------ALKTTIFR----------------------Pv-- 228 Kazachstania af...
XP_001560890 214 AFPDAggYVLLKFLTNPVPpsstYD--------------------ARVESSVLR----------------------Padp 251 Botryotinia fuc...
XP_001525872 213 MMDNV--LMNLRFLGSASIdrelKDLKRKRgtafnekfE-----RQKQESSIFK----------------------Pi-- 261 Lodderomyces el...
XP_004199563 219 MLDSK--FLNVKFFGSASFsremQLLKRQEkekydeqfQ-----KNSLETSIFR----------------------Pi-- 267 Pichia farinosa...

Q17LJ8       250 ----------------------------MDESG--------------EQ-------FVAY--FLPSEETLEKRR------ 272 yellow fever mo...
Q9US06       242 ----------------------------SSAEG--------------EE-------FLSY--YLPSEETAEEI------- 263 Schizosaccharom...
EHK48006     272 ----------------------------SNPKP--------------AN-------LMNYdfYLGQSRADADRF------ 296 Trichoderma atr...
ETS06374     251 taaeeaaleaameaytqdpvnnpkpanlMNYD---------------------------F--YLGQTRADADRF------ 295 Trichoderma ree...
CCE27944     253 teaee---------------aayeaaleAHEQD--------------PEnnpsphnLMNYdfYLGQSSTVARNF------ 297 Claviceps purpu...
EPY53462     238 ----------------------------SSAEG--------------EQ-------YLSY--YLPSEESAEKIQ------ 260 Schizosaccharom...
XP_003954938 229 -----------------------------ELEE--------------DE-------WMSM--YTTDMKDSETLE------ 250 Kazachstania af...
XP_001560890 252 te----------------------aeleMKEAArqayeldphnnpppDE-------KIQYemFMPDTVTDAKNIkrkfdv 302 Botryotinia fuc...
XP_001525872 262 ----------------------------NSEDG--------------E--------WMSM--FEVNDISQAEQV------ 283 Lodderomyces el...
XP_004199563 268 -----------------------------TSDD--------------GE-------WISL--YQSKDPQRTQIL------ 289 Pichia farinosa...

Q17LJ8       273 -------R-------------D------LVN-----------ET----LY-----Ed-eEEYEYKMAREYNWNVKS--KA 303 yellow fever mo...
Q9US06       264 ---------------------Q------AKV-----------ND----AS-----AdvhEPFVYNHFRNFDASM------ 290 Schizosaccharom...
EHK48006     297 -------RrkfdvddadrdeeD------LYT-----------HR----GD-----Tg--GYFQFNRIRAYETAQET--EL 339 Trichoderma atr...
ETS06374     296 -------RrkfdvddpshdddD------LYT-----------HK----AD-----Tg--GYFQFNRIRAYETAQET--EL 338 Trichoderma ree...
CCE27944     298 -------RrkfdiedadrdntD------LYT-----------HQ----GE-----Tg--PYFQFNRVRAYETADER--EL 340 Claviceps purpu...
EPY53462     261 ---------------------Q------ASN-----------NS----SS-----Te--GPFLYNLFRNFDASMLV--NP 289 Schizosaccharom...
XP_003954938 251 -------K-------------S------IER-----------VI----DEnltadDs-nKVFRFRRLRDFDMKQAK--ST 286 Kazachstania af...
XP_001560890 303 ldpehddR-------------D------LYS-----------QF----DE-----EtgkGAFRLKRLRGYETVQTSggTD 343 Botryotinia fuc...
XP_001525872 284 -------H-------------Q------KLNstapeqpinllDL----DD-----Es-aSNYNFKFVHNYDMQYQE--YP 325 Lodderomyces el...
XP_004199563 290 -------K-------------DklnsseKEK-----------QVyvldEE-----Ed-aEEYKFEHIKEYDMSFQR--Y- 329 Pichia farinosa...

Q17LJ8       304 Skgy----eenYFLVLRQD------------GMYYNELETRVRLSKRRQKvgq-----------qpNNTKLVVKHRPLNA 356 yellow fever mo...
Q9US06       291 HvnstgledlcLTFHTDKdhp-------eanQVLYTPIYARSTLKRRHVRapv----------sldAVDGIELSLRDLND 353 Schizosaccharom...
EHK48006     340 Dhptk--yedeIILSINEKdtda-----sqkAVFYYPIMQRSTIRPQRTRniartnyglaeddepqVVDQLDLTVDEPTE 412 Trichoderma atr...
ETS06374     339 Dhptky-edeiILAVNDDTtyp------kqkAVYYYPIMQKSTIRPQRTKniartnygladddeaqVVDQLDLTVEDPTE 411 Trichoderma ree...
CCE27944     341 Dhptky-sdeiIVAYNDVDayp------rqkAMYYYPIMQKSTIRPQRTKniartig--inadeeqMVDQLDITVEDPTE 411 Claviceps purpu...
EPY53462     290 Sgle----dlcLSICTDQEnpk-------nnKALYTPIYARSTLKRRHVRapv----------npdTIDGIELTLREPNR 348 Schizosaccharom...
XP_003954938 287 Dssl-----seLAIVLNNEk----------gVAYYKPLRTRIELRRRRVNdvikp------lvtehNIDQLNISLRNPTT 345 Kazachstania af...
XP_001560890 344 Dkyd----eyvVIAMHDGTdgl------hqkAAHYYPVVQRSSIRPQRTKniqkmrhn-isgeeeeVLDMVDLSIVDPGA 412 Botryotinia fuc...
XP_001525872 326 Evnq----elaIKFIPDDEhkdtkaptkkrkVAYYLPVTGKIELRKHRLStnsein----kfvkerTYDEVAFKLREPST 397 Lodderomyces el...
XP_004199563 330 Nkpy-----eeLAIKFASEgepnskgdrkrkAAYYYPVTGKIDLKKHRAStnaein----rfirdsAYDIVNYKLREPNT 400 Pichia farinosa...

Q17LJ8       357 SEHRMQRYRERQ---LEP-----PGE-EDDEDIEEEEEEeEDMEEEIQET----QEEE-GAEKDEEGEEDKDEdarRSRS 422 yellow fever mo...
Q9US06       354 EESLQLKRARYDtfgLGN-----IKD-LEEEEEKLRSVE---GSLNEELSeeekPAES-REQLESAEQTNGVK---PETQ 420 Schizosaccharom...
EHK48006     413 EMRAAMKMYARHp--MGW-----EQD-EEDE-----------LHQGVERSieegDVDA-DGDAEGEDADRNGA---SSPA 469 Trichoderma atr...
ETS06374     412 EMRGAMKMYAEHp--LGW-----DQE-EGAEEHEHEQEH-EHEHEHIEQSiedaDVDAdGEEAERNGASSPGG---QERS 479 Trichoderma ree...
CCE27944     412 EMLDAMKKYKNHplgWEQ-----EPD-EEDIAAGATQEQ-Gpdadgdadadvevdgeadadaeagadadpepdadveang 484 Claviceps purpu...
EPY53462     349 EESVQLKRARYD---SFA-----MGDvEALEKEEQEIAE-EQAGEENELNeieeQHQD-ENPLPNPSENPQPL---PTEE 415 Schizosaccharom...
XP_003954938 346 SEVNTRDRLRMKfdpINF-----VPV------DEEEEEK-EEESREDDMSkekhDDNE-QHKHEDLDSTQNQI---TGKA 409 Kazachstania af...
XP_001560890 413 ETKQVMEGFKTW---PYG-----ENH-EDDAERDAAEVE-DALSEADAEGedddlnspvrpslggktiasrvqsdeeddd 482 Botryotinia fuc...
XP_001525872 398 NELKEMDRARSE---FDPmeyegDDD-DEEEEDDDDEEE-LEDGEDYEEReeqeELES-RQGRSNGNAESGAD---QESV 468 Lodderomyces el...
XP_004199563 401 NEMRRMDTIRSE---FDP----------MEYEGEEEVAE-TNETQPNEEEqekkDQDN-GSSINNDQENNGET---KPED 462 Pichia farinosa...

Q17LJ8       423 RSGSRSRS-V 431 yellow fever mosquito
Q9US06       421 AQNMSASEsQ 430 Schizosaccharomyces pombe 972h-
EHK48006     470 EKYHERSPsA 479 Trichoderma atroviride IMI 206040
ETS06374     480 PSAHRDAEgD 489 Trichoderma reesei RUT C-30
CCE27944     485 vgdkhsqade 494 Claviceps purpurea 20.1
EPY53462     416 SGQLSTKNeQ 425 Schizosaccharomyces cryophilus OY26
XP_003954938 410 DSKEDEVEkA 419 Kazachstania africana CBS 2517
XP_001560890 483 eneslhsed- 491 Botryotinia fuckeliana B05.10
XP_001525872 469 DGKVKHDReD 478 Lodderomyces elongisporus NRRL YB-4239
XP_004199563 463 DSSLKNQEeT 472 Pichia farinosa CBS 7064
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