Conserved Protein Domain Family
PHD_PHF3
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cd15638: PHD_PHF3 
PHD finger found in PHD finger protein 3 (PHF3)
PHF3 is a human homolog of yeast protein bypass of Ess1 (Bye1), a nuclear protein with a domain resembling the central domain in the transcription elongation factor TFIIS. It is ubiquitously expressed in normal tissues including brain, but its expression is significantly reduced or lost in glioblastomas. PHF3 contains an N-terminal plant homeodomain (PHD) finger, a central RNA polymerase II (Pol II)-binding TFIIS-like domain (TLD) domain, and a C-terminal Spen paralogue and orthologue C-terminal (SPOC) domain.
Links
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Statistics
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PSSM-Id: 277108
Aligned: 4 rows
Threshold Bit Score: 111.555
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding sitehistone H3
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #  #           #  #    #  #                   #  #
Q92576     719 QCgfCKKPHGNrFMVGCGRCDDWFHGDCVGLSLSqaqqMGEEDKEYVCVKC 769  human
EMP34983   735 QCgfCRKPHGNrFMVGCGRCDDWFHGDCVGLSLSqaqrMGEEDKEYVCVKC 785  green seaturtle
AAH92387   554 CCs-CRKLHGNkFMVGCGRCDDWFHGECLGLSLSqaqhMETEDKEYLCPKC 603  African clawed frog
AAH90712   625 NCvlCKKPHNNrFMVGCGRCDDWFHGDCVGLDLAkvqqMEKEDQEYVCLKC 675  zebrafish

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