1Y8M,1PC2,2PQN,3O48,1NZN,1IYG,3UUX


Conserved Protein Domain Family
Fis1
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cd12212: Fis1 
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Mitochondrial Fission Protein Fis1, cytosolic domain
Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 276936
Aligned: 55 rows
Threshold Bit Score: 93.3863
Created: 26-Jan-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:Mdv1 is recruited by Fis1 to the mitochondrial outer membrane to facilitate fission
  • Structure:3UUX: Saccharomyces cerevisiae Fis1-Mdv1 complex; contacts at 4A.
    - View structure with Cn3D
  • Structure:2PQN: Saccharomyces cerevisiae Fis1 bound to Mdv1 fragment, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  ##  #                   ### ##  #        #  ## ##  #  ## #              
1Y8M_A        16 PLYPQQLEILRQQVVSEGgp---------tATIQSRFNYAWGLIKSTdVNDERLGVKILTDIYKEAe------------- 73  baker's yeast
3UUX_C        16 PLYPQQLEILRQQVVSEGgp---------tATIQSRFNYAWGLIKSTdVNDERLGVKILTDIYKEAe------------- 73  Saccharomyces c...
Q9M1J1        23 PWCDGDVIAGCEREVREAtdsg-----tedLKKECLMRLSWALVHSRqTEDVQRGIAMLEASLESSap------------ 85  thale cress
XP_004346793  39 SIVGLVRSRFEREHNDLIlrt-------gsSTDNAKFNYAWCLVKSRfRGDNRRGIEMFQDLLASGd------------- 98  Capsaspora owcz...
XP_001764446  24 PWTDSEMIASCELEASGEkaa------vsgDNNDSIMRLAWALVHSRnPPDVQRGIAMLEASLAGVga------------ 85  Physcomitrella ...
XP_002958416   8 SVDLDFVKHAEDEYHSIYqtg------tsdEVDGARFRLVWALVHSTnRSHQSRGLELCRAKLREQa------------- 68  Volvox carteri ...
XP_001418662  38 AEYGRILARSKDVVVRDAdra------tdaEVRRARFNMVWALCHSGvEDQLRRGTQMLERGASNGanaettlearwrve 111 Ostreococcus lu...
EFN52415      34 PYTEPELIQQCQKEYEEAaqh------ggqEALDACFRLSWALVHSQvPGEVQRGIELAEALTDSAg------------- 94  Chlorella varia...
XP_003113470   3 PESILDFRTENEDILAARar---------sVTRENQIQLAIVLVGSEnPKEVEEGAAILEEIVKDTih------------ 61  Caenorhabditis ...
CBY22179       8 TFNEKNIADLRENYNLSIgqfqatnsvnkeAFYQTKFQLAHGLILSEnQRDINEGIDFLKQLIREHen------------ 75  Oikopleura dioica

Feature 1             #### # #       # #  #  ##  #                           
1Y8M_A        74 ----sRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHErNNKQVGALKSMVEDKIQKETL 129 baker's yeast
3UUX_C        74 ----sRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHErNNKQVGALKSMVEDKIQKETL 129 Saccharomyces cerevisiae S288c
Q9M1J1        86 ---plEDREKLYLLAVGYYRSGNYSRSRQLVDRCIEMQaDWRQALVLKKTIEDKITKDGV 142 thale cress
XP_004346793  99 -----RDRECLFFIALGYYRLGEYPNARVYVKRLLQIEpRNRQALQLDAAIDKLVSKDTL 153 Capsaspora owczarzaki ATCC 30864
XP_001764446  86 ---pmQKREILYLLAVGQFRAGEYARSRRLLDQALQISpDFRQAAGLKKVVEDKIAKDGL 142 Physcomitrella patens subsp. patens
XP_002958416  69 -----KDKEFRYFAAVASYNLGQYIEARRELSSLLQEHpGFRQAEFLRGLVEDAIVREGL 123 Volvox carteri f. nagariensis
XP_001418662 112 fgdamEVRDGHYLRSVAYYGMRDYERAREAAFAALKCDpECRQAAALREASEEALARDGL 171 Ostreococcus lucimarinus CCE9901
EFN52415      95 ----lDQRDLLYLVAVGKYRQRRYIEARRTLKGLMQVHpEFRQAEGLLEACDREIVKDGL 150 Chlorella variabilis
XP_003113470  62 ---seDSRVCVHYLALAHARLQNYDKSVRLLDALLRTEpSNMQATELRRVVEKKMKREGL 118 Caenorhabditis remanei
CBY22179      76 ---mtANRDYAYFIAIGLLRQKKYEDCMRKCEQILRVEpENHQVKQLSVAAEKNLRKEGL 132 Oikopleura dioica

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