Conserved Protein Domain Family
MYSc_Myh13
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cd14923: MYSc_Myh13 
class II myosin heavy chain 13, motor domain
Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276887
Aligned: 15 rows
Threshold Bit Score: 1029.63
Created: 8-Jan-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #########                                           #
Q076A3        100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  dog
AAG43570      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  rabbit
NP_001074719  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  house mouse
EDL10432      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  house mouse
NP_001156538  100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  rabbit
DAA18765      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  cattle
EHB04540       98 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVGAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 177  naked mole-rat
ELK03872      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  black flying fox
ELR48002      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  Bos grunniens...
ELW53081      100 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVSAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 179  Chinese tree ...

Feature 1         #######                                                ###########              
Q076A3        180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  dog
AAG43570      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  rabbit
NP_001074719  180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  house mouse
EDL10432      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  house mouse
NP_001156538  180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  rabbit
DAA18765      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  cattle
EHB04540      178 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 257  naked mole-rat
ELK03872      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQLGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  black flying fox
ELR48002      180 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  Bos grunniens...
ELW53081      180 ESGAGKTVNTKRVIQYFATIAVTGEKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259  Chinese tree ...

Feature 1                                                                                         
Q076A3        260 LASADIETYLLEKSRVTFQLSSERSYHIFYQILSNKKPELIDLLLISTNPFDFPFVSQGEVTVASINDSEELLATDNAID 339  dog
AAG43570      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  rabbit
NP_001074719  260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  house mouse
EDL10432      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  house mouse
NP_001156538  260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  rabbit
DAA18765      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  cattle
EHB04540      258 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 337  naked mole-rat
ELK03872      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  black flying fox
ELR48002      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  Bos grunniens...
ELW53081      260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 339  Chinese tree ...

Feature 1                                                                                         
Q076A3        340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  dog
AAG43570      340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  rabbit
NP_001074719  340 ILGFSPEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  house mouse
EDL10432      340 ILGFSPEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  house mouse
NP_001156538  340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  rabbit
DAA18765      340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  cattle
EHB04540      338 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 417  naked mole-rat
ELK03872      340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  black flying fox
ELR48002      340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  Bos grunniens...
ELW53081      340 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 419  Chinese tree ...

Feature 1                                                    ######                               
Q076A3        420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  dog
AAG43570      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  rabbit
NP_001074719  420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  house mouse
EDL10432      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  house mouse
NP_001156538  420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  rabbit
DAA18765      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  cattle
EHB04540      418 QQVTNAVGALAKAVYEKMFLWMVNRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 497  naked mole-rat
ELK03872      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  black flying fox
ELR48002      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  Bos grunniens...
ELW53081      420 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 499  Chinese tree ...

Feature 1                                                                                         
Q076A3        500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  dog
AAG43570      500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  rabbit
NP_001074719  500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  house mouse
EDL10432      500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  house mouse
NP_001156538  500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  rabbit
DAA18765      500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  cattle
EHB04540      498 QEEYKKEGIEWTFIDFGMDLAACIELIEK--------------------------------------------------- 526  naked mole-rat
ELK03872      500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  black flying fox
ELR48002      500 QEEYKKEGIEWEFIDFGMDLAACIELIEK--------------------------------------------------- 528  Bos grunniens...
ELW53081      500 QEEYKKEGIDWEFIDFGMDLAACIELIEKkmflwmvtrinqqldtkqprqyfigvldiagfeifdfnsleqlcinftnek 579  Chinese tree ...

Feature 1                                                                                         
Q076A3        529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  dog
AAG43570      529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  rabbit
NP_001074719  529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  house mouse
EDL10432      529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  house mouse
NP_001156538  529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  rabbit
DAA18765      529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  cattle
EHB04540      527 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 564  naked mole-rat
ELK03872      529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  black flying fox
ELR48002      529 ------------------------------------------PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 566  Bos grunniens...
ELW53081      580 lqqffnhhmfvleqeeykkegidwefidfgmdlaacieliekPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQ 659  Chinese tree ...

Feature 1                                                                                         
Q076A3        567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  dog
AAG43570      567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSALKLLSFLFSNYAgaeag-------------- 632  rabbit
NP_001074719  567 KPkptKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  house mouse
EDL10432      567 KPkptKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  house mouse
NP_001156538  567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSALKLLSFLFSNYAgaeag-------------- 632  rabbit
DAA18765      567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  cattle
EHB04540      565 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 630  naked mole-rat
ELK03872      567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  black flying fox
ELR48002      567 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaeag-------------- 632  Bos grunniens...
ELW53081      660 KPkpaKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAgaetvadkagylmglnsae 739  Chinese tree ...

Feature 1                                                                                         
Q076A3            --------------------------------------------------------------------------------      dog
AAG43570          --------------------------------------------------------------------------------      rabbit
NP_001074719      --------------------------------------------------------------------------------      house mouse
EDL10432          --------------------------------------------------------------------------------      house mouse
NP_001156538      --------------------------------------------------------------------------------      rabbit
DAA18765          --------------------------------------------------------------------------------      cattle
EHB04540          --------------------------------------------------------------------------------      naked mole-rat
ELK03872          --------------------------------------------------------------------------------      black flying fox
ELR48002          --------------------------------------------------------------------------------      Bos grunniens...
ELW53081      740 mlkglccprvkvgneyvtkgqnvqqvtnsvgalakavyekmflwmvtrinqqldtkqprqyfigvldiagfeifdfnsle 819  Chinese tree ...

Feature 1                                                                                         
Q076A3            --------------------------------------------------------------------------------      dog
AAG43570          --------------------------------------------------------------------------------      rabbit
NP_001074719      --------------------------------------------------------------------------------      house mouse
EDL10432          --------------------------------------------------------------------------------      house mouse
NP_001156538      --------------------------------------------------------------------------------      rabbit
DAA18765          --------------------------------------------------------------------------------      cattle
EHB04540          --------------------------------------------------------------------------------      naked mole-rat
ELK03872          --------------------------------------------------------------------------------      black flying fox
ELR48002          --------------------------------------------------------------------------------      Bos grunniens...
ELW53081      820 qlcinftneklqqffnhhmfvleqeeykkegidwefidfgmdlaacieliekpmgifsileeecmfpkatdtsfknklyd 899  Chinese tree ...

Feature 1                                                                                         
Q076A3        633 ----------------------------------------------------------------------------dsgg 636  dog
AAG43570      633 ----------------------------------------------------------------------------dsgg 636  rabbit
NP_001074719  633 ----------------------------------------------------------------------------dsag 636  house mouse
EDL10432      633 ----------------------------------------------------------------------------dsag 636  house mouse
NP_001156538  633 ----------------------------------------------------------------------------dsgg 636  rabbit
DAA18765      633 ----------------------------------------------------------------------------dsga 636  cattle
EHB04540      631 ----------------------------------------------------------------------------darg 634  naked mole-rat
ELK03872      633 ----------------------------------------------------------------------------dsgg 636  black flying fox
ELR48002      633 ----------------------------------------------------------------------------dsga 636  Bos grunniens...
ELW53081      900 qhlgksnnfqkpkpakgkaeahfslvhyagtvdyniagwldknkdplnetvvglyqksslkllsflfsnyagaetgdtgg 979  Chinese tree ...

Feature 1                                                                                         
Q076A3        637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 716  dog
AAG43570      637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 716  rabbit
NP_001074719  637 gKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 716  house mouse
EDL10432      637 gKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 716  house mouse
NP_001156538  637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 716  rabbit
DAA18765      637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHHLVLHQLRCNGVLEGIRICRKGFPSR 716  cattle
EHB04540      635 sKKGGKKKGSSFQTASAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 714  naked mole-rat
ELK03872      637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHSLVMHQLRCNGVLEGIRICRKGFPSR 716  black flying fox
ELR48002      637 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHHLVLHQLRCNGVLEGIRICRKGFPSR 716  Bos grunniens...
ELW53081      980 sKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSR 1059 Chinese tree ...

Feature 1                                                               
Q076A3        717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLSSIDVDREQYRFGHTKVFFK 770  dog
AAG43570      717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 770  rabbit
NP_001074719  717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGHTKVFFK 770  house mouse
EDL10432      717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGHTKVFFK 770  house mouse
NP_001156538  717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 770  rabbit
DAA18765      717 ILYGDFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 770  cattle
EHB04540      715 LLYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDQEQYRFGHTKVFFK 768  naked mole-rat
ELK03872      717 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLSSIDVDREQYRFGHTKVFFK 770  black flying fox
ELR48002      717 ILYGDFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQYRFGHTKVFFK 770  Bos grunniens mutus
ELW53081     1060 ILYADFKQRYRILNASAIPEGQFIDSKNASEKLLGSIDVDRDQYRFGHTKVFFK 1113 Chinese tree shrew

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