1A1F,2DRP,1A1H,1A1I,1AAY,1F2I,1G2F,1JK1,1MEY,1TF3,1TF6,1UN6,2KMK,2LT7,2WBU,3UK3,4GZN,1UBD,1BBO


Conserved Protein Domain Family
ZF_C2H2
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sd00019: ZF_C2H2 
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Zinc finger, C2H2 type
The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
Links
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Statistics
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PSSM-Id: 275370
Aligned: 291 rows
Threshold Bit Score: 29.8919
Created: 21-Dec-2011
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1TF6: Xenopus TFIIIA zinc finger contacts to Zn ion.
    - View structure with Cn3D
  • Comment:The small C2H2 zinc finger domain is conformationally stabilized by coordinating a zinc ion on the two invariant cysteine and histidine residues.
  • Citation:PMID 2028256
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #    #            #    #                                         
1A1F_A          7 CPveSCDRRFSDSSNLTRHIr-IHtgqk----------pfqCRI--CMRNFSRSDHLTTHI-RTH 57   house mouse
1TF6_A         15 CSfaDCGAAYNKNWKLQAHLc-KHtgek----------pfpCKEegCEKGFTSLHHLTRHS-LTH 67   African clawed frog
XP_004181192  698 CKweNCSRKFKSLFDLQSHI--LHehlaieaqkqdakrnfdCQWkdCQTQSNDICTLINHInTDH 760  Tetrapisispora blattae CBS 6284
NP_001100873   28 CS--QCEEGFDFPEDLQKHIaeCHpecspne----draalqCVY--CHELFVEETSLMNHIeQVH 84  
CAG04760      299 CD--ICGKRFTHLRSLERHHl-VHtger----------phrCPQ--CGRSFSRLGNLERHQ-RIH 347  spotted green pufferfish
NP_001004998  133 CE--ICAKGFRLQRMLNRHLk-CHnqvk----------rhlCTF--CGKGFNDTFDLKRHV-RTH 181 
NP_001019784  262 CE--VCGKVFNAHYNLTRHMp-VHtgar----------pfvCKV--CGKGFRQASTLCRHK-IIH 310 
EGI64272      177 CG--VCQRSFGYKHVLQNHEr-THtgek----------pfqCQE--CQKRFTRDHHLKTHM-RLH 225  Panamanian leafcutter ant
XP_003387259  345 CQ--ICQRIFTSQGSLRAHAr-IHtgek----------pyqCQF--CKRVFTQASTLRSHE-RLH 393  Amphimedon queenslandica
XP_003387382  432 CG--RCQESFYALHKLQDHIr-KHegqr----------rfhCEY--CNKSFTQRGSLNTHI-RIH 480  Amphimedon queenslandica

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