4LWZ,4J5M,4LNZ


Conserved Protein Domain Family
Myo5b_CBD
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cd15477: Myo5b_CBD 
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Cargo binding domain of myosin 5b
Class V myosins are well studied unconventional myosins, represented by three paralogs (Myo5a,b,c) in vertebrates. Their C-terminal cargo binding domains (CBDs) are important for the binding of a diverse set of cargos, including membrane vesicles, organelles, proteins and mRNA. They interact with several adaptor proteins, in case of Myo5b-CBD, Rab11-family interacting protein 2.
Links
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Statistics
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PSSM-Id: 271261
Aligned: 10 rows
Threshold Bit Score: 750.538
Created: 17-Apr-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Rab11 interface
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:Rab11 interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              # ##                                                       
4LWZ_B         53 KEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNT 132  human
4J5M_A         22 KEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNT 101  human
4LNZ_A         20 KEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNT 99   human
XP_005815462 1517 KEDEARLIKTLITDIQPSTVSATVPCLPAYILFMCIRHADYINDDQKVISLLTSSINAIKKVLKRNNDDFEMISFWLANS 1596 southern plat...
XP_005060402 1449 KEDEPRLIRNLITDLKPQAVSATVPCLPAYILYMCIRHADYINDDQKLNSLLTSTINGLKKVLKKHHNDFEMTSFWLANT 1528 collared flyc...
XP_006030092  176 KEDEPLLVRNLITDLKPQTVSTTVPCLPAYILYMCIRHADYVNDDQKVHSLLTSTINGIKKVLKKHNDDFQMTSFWLANT 255  Chinese allig...
XP_004616187 1326 RDDEALLVRSLVTELRPQALVGAVPCLPAYILYMCVRHADYTNDDAKLHSLLTATINGIKRVIKKHSEDFEVTSFWLANS 1405 European shrew
XP_007250150 1227 KEDEALLIRTLVTDMKPHVVSATVPCLPAYILFMCIRHADYINDDQKVHSMLTSTINAVKKVLKKNNDDFEMTSFWLANT 1306 Mexican tetra
XP_002936554 1436 KEEEPLLVRNLIIDVKPEQMSSMVPCLPAYILFMCIRHADYINDDQKVHSLLTSTINGIKKVLKKHHSEFQITSFWLSNS 1515 western clawe...
NP_001155104 1462 KEDEALLVKTLVTDMKPNAVSATVPCLPAYILFMCIRHADYINDDQKVHSLLTATINAIKKVLKKNNDDFEMTSFWLANA 1541 zebrafish

Feature 1          #                                                                              
4LWZ_B        133 CRLLHCLKQYSGdegfmtqNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENesiqglsgv 212  human
4J5M_A        102 CRLLHCLKQYSGdegfmtqNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENesiqglsgv 181  human
4LNZ_A        100 CRLLHCLKQYSGdegfmtqNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENesiqglsgv 179  human
XP_005815462 1597 SRLLHCLKQYSGeeafmtqNTTKQNEHCLKNFDLAEYRQILSDLSIQIYQQLIKVAQGIIQPMIVSAMLESesipslagv 1676 southern plat...
XP_005060402 1529 CRLLHCLKQYSGeecfmtqNTAKQNEHCLQNFDLVEYRHAFSQLSIQIYQQLINVAETILHPMIVSAVLEDesipglssv 1608 collared flyc...
XP_006030092  256 CRLLHCLKQYSGdtgfmtqNTAKQNEHCLKNFDLAEYRQVLSDLSIQIYQQLIKIAEGMLQPMIVSAMLENesiqglsgv 335  Chinese allig...
XP_004616187 1406 CRLLHCLKQYSGdegfmtqNTAKQNEHCLKNFDLTEYRQVLSDLSIHIYQQLIRVAEGVLQPMIVSAMLENesiqglsgm 1485 European shrew
XP_007250150 1307 SRLLHCLKQYSGdeafmtqNTSKQNEHCLKNFDLAEYRQVLSDLSIQIYQQLIKIAESILQPMIVSAMLESgsltgvkpm 1386 Mexican tetra
XP_002936554 1516 SRLLHCLKQYSGdegfmtsNSPKQNEHCLRNFDLTEYRQVLSDLSIQIYQQMIKIAETHMQPMIVSAMLETesiqglsgv 1595 western clawe...
NP_001155104 1542 SRLLHCLKQYSGdeafmtqNSAKQNEHCLKNFDLAEYRQVLSDLSIQIYQQLVKVAEANMQPMIVSAMLESesipslagv 1621 zebrafish

Feature 1                                               #    ##                              #   #
4LWZ_B        213 kptgy---rkrsssmadgdnsYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGM 289  human
4J5M_A        182 kptgy---rkrsssmadgdnsYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGM 258  human
4LNZ_A        180 kptgy---rkrsssmadgdnsYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGM 256  human
XP_005815462 1677 ksmgyrnrsssmdtdadgpttYTLQGLIRQLSQFNSIMRDHGLDPEVVGQVARQLFHCINAFTLNNLLLRKDICSWSTGM 1756 southern plat...
XP_005060402 1609 kplgy--rkyssnsaegdnnsYTLDEMIHQLNTFHSIMCDQGLDPEIIQQVFKQLFYMINAVTLNNLLLRKDVCSWNTGM 1686 collared flyc...
XP_006030092  336 kpmgy---rkrsssmpdgdntYSLDAVVRQLNTFHSIMCEQGLDPEIIQQAFKQLFYMINAVTLNNLLLRKDVCSWSTGM 412  Chinese allig...
XP_004616187 1486 kpmgy---rkrsssmvdgensYCLEAVMRQMTTFHTVMGDQGLDPEIILQVFRQLFYMINAVTLNNLLLRKDVCSWSTGM 1562 European shrew
XP_007250150 1387 gyrnr---sssmdcetggpggYTLEALIRQLGQFNTIMGEHGLDPEIGQQVIRQLFYSINAVTLNNLLLRKDVCSWSTGM 1463 Mexican tetra
XP_002936554 1596 kqtgy---rkrtssmadgdnsYSLEAVIRQLNTFNSIMCDHGLDPEIIQQVFKQLFYMINAVTLNNLLLRKDVCSWSTGM 1672 western clawe...
NP_001155104 1622 kpmgyrnrsssvdcesggpagYTLQALIKQLAQFYSTMADHGLDPEISQQVLRQLFYSINAVTLNNLLLRKDVCSWSTGM 1701 zebrafish

Feature 1           ##  ##  #  #  #                 #  ##             #                      #    
4LWZ_B        290 QLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVT 369  human
4J5M_A        259 QLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVT 338  human
4LNZ_A        257 QLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVT 336  human
XP_005815462 1757 QLRYNTSQLEEWLRANNLFQSKASATLEPIIQAAQLLQVKKKTSQDAEAICSLCTALTVQQIVKILNLYTPLNEFEERVT 1836 southern plat...
XP_005060402 1687 QLRFNISQLEEWLRGKNLQQSGAAKTLEPLIQAAQLLQLKKKTSEDANAICSLCTSLMTQQIVKILNLYTPVNEFEERVT 1766 collared flyc...
XP_006030092  413 QLRFNISQLEEWLHGKNLQQSGAAQTMEPLIQAAQLLQLKKKTSEDAEAICSLCTSLTTQQIVKILNLYTPVNEFEERVT 492  Chinese allig...
XP_004616187 1563 QLRYNISQLEEWLRGRNLQQSGAAQTLEPLIQAAQLLQLKKKTPEDAEAICSLCTALSTQQIVKILNLYTPLNEFEERVT 1642 European shrew
XP_007250150 1464 QLRYNISQMEEWLRGRNLHQSGVMATIEPLIQAAQLLQVKKKTSQDAEAICTLCSALTTQQIVKILNLYTPLNEFEERVT 1543 Mexican tetra
XP_002936554 1673 QLRYNISQLEEWLRGKNLHPSGAAQTMEPLIQAAQLLQLKKKTEEDAEAICSLCTALTTQQIVKILNLYTPVNEFEERVT 1752 western clawe...
NP_001155104 1702 QLRYNISQLEEWLRGKNLHQCGAVATMEPVIQAAQLLQVKKKTSQDAEAICSLCTALSLQQIVKILNLYTPLNEFEERVT 1781 zebrafish

Feature 1                                           #####                
4LWZ_B        370 VAFIRTIQAQLQERNDPQQLLLDaKHMFPVLFPFNPSSLTMDSIHIPACLNLEFL 424  human
4J5M_A        339 VAFIRTIQAQLQERNDPQQLLLDaKHMFPVLFPFNPSSLTMDSIHIPACLNLEFL 393  human
4LNZ_A        337 VAFIRTIQAQLQERNDPQQLLLDaKHMFPVLFPFNPSSLTMDSIHIPACLNLEFL 391  human
XP_005815462 1837 VSFIRNVQSVLQERNDPPQLLLDtKHTFPVLFPYAPSALSLEAVRIPPSLGLDFL 1891 southern platyfish
XP_005060402 1767 VTFIRNIQKLLQERNDPPQLLLDfKHVFPVQFPYNPSAITLDSIHLPASLKLDFL 1821 collared flycatcher
XP_006030092  493 VAFIRNIQAHLQERNDPPQLLLDfKYTFPVLFPFSPSSITMDSIHIPASLNLEFL 547  Chinese alligator
XP_004616187 1643 VGFIRTIQAQLQERNDPPQLLLDfKHMFPVVFPFNPSSLTMDSIHIPASLNLEFL 1697 European shrew
XP_007250150 1544 VSFIRDIQNRLQDRIENKQLLVDtKHTFPVLFPYTPSALSLETIHMPASLNLDFL 1598 Mexican tetra
XP_002936554 1753 VSFIRIIQAQLQERNDPPQLLMDsKYMFPVLFPFSPSAITLDTIQIPPSLKLDFL 1807 western clawed frog
NP_001155104 1782 VSFIRDIQNRLQDRIENNQLLADtKYTFPVLFPYTPSNLSLETIHIPASLSLDFL 1836 zebrafish

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