Conserved Protein Domain Family
SGNH_hydrolase_like_5
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cd01842: SGNH_hydrolase_like_5 
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Links
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Statistics
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PSSM-Id: 238880
Aligned: 4 rows
Threshold Bit Score: 321.372
Created: 16-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:the histidine side chain may be oriented by a backbone oxygen or by an acidic sidechain
  • Citation:PMID 7773790
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                       #                                
XP_136686  17 FVVVLGDSIQRAvykdlvlllqkdcllsssqlkskgelsFERDVLLEGGRWgrmhngahyrevrqfcsgrhlirfy-flt 95  house mouse
AAH86831   12 FVVVLGDSIQRAvykdlvlilqkdshlsasqlkskgefsFENDTLVEGGRLgemnngtqyrevrqyrtdhhlvrf--yfi 89  zebrafish
XP_786568  20 FVVILGDSIQRGiykdlvallqgneylssqdlkakgeknFMNDVLLEGGKMhnginyrevrqyrtdyhllrfyf----it 95  purple urchin
CAI12119   34 FVVILGDSIQRAvykdlvlllqkdslltaaqlkakgelsFEQDQLVAGGQLgelhngtqyrevrqfcsgsghhlvrfyfl 113 human

Feature 1                               #                                                     
XP_136686  96 rayspyvedilqqlrwgeyapDLVIMNSCLWDLSry-rsNFLRNYREDLERLfqrldqvlpthCLMVWSTTMpvaevvsg 174 house mouse
AAH86831   90 trtfsqyvesiisdfekgikpDLVVVNSCVWDISry-srQWAVEYRENLKKLfmklksvlpeeSLVIWNMTMplgrkilg 168 zebrafish
XP_786568  96 rihnkyweeiilpdlqgdpvpDVVIMNSCLWDVSrygqyNSMKTFKRNIETTfsklnsilpieTLIMWNTALpvaeeikg 175 purple urchin
CAI12119  114 trvyseyledvleeltygpapDLVIINSCLWDLSry-grCSMESYRENLERVfvrmdqvlpdsCLLVWNMAMplgeritg 192 human

Feature 1                                                         #  #                  
XP_136686 175 gfilrdapgcPSRLREDVMEANFyssreaarrgFDVLDLHFHfrhagqhrlsDGVHWDERAHRYLSQLLLAHVA 248 house mouse
AAH86831  169 gflvpeiehmGPSLRFDVIEANYfgatlanesgFDVLDLHYQfrfslqhrtrDGVHWNAVAHRKLSSLLLQHVA 242 zebrafish
XP_786568 176 gfllpelhdlSKTMRYDVLLGNFyakelakcyeIDVLDLNYFfrhqmhrqvgDGVHWNYVAHRRITNLVLAHIA 249 purple urchin
CAI12119  193 gfllpelqplAGSLRRDVVEGNFysatlagdhcFDVLDLHFHfrhavqhrhrDGVHWDQHAHRHLSHLLLTHVA 266 human

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