4RHN,6FIT,1FHI,1HXP,1HXQ,1GUQ,1EMS


Conserved Protein Domain Family
HIT_like
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cd00468: HIT_like 
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HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literacture into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Further sequence analysis reveals several new closely related, yet uncharacterized subgroups.
Links
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Statistics
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PSSM-Id: 238263
Aligned: 9 rows
Threshold Bit Score: 97.5386
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site/active site [active site]
Evidence:
  • Structure:4RHN: HINT-adenosine complex
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  • Structure:6FIT: Fhit substrate-analog complex (AMP-CP,adenosine alpha/beta-methylene)
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  • Structure:1FHI; Fhit transition state analog complex (tungstate and adenosine)
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  • Structure:1GUQ_A:_A:structure of galactose-1-phosphate complexed with udp glucose
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # #                            # #                                     
4RHN         21 IFEDdqcLAFHDisp---------------------qapTHFLVIP-KKHisqisaaedadesLLGHLMIVGKkcaad-- 76  rabbit
6FIT         16 FLKTelsFALVNrkp---------------------vvpGHVLVCP-LRPverfh---dlrpdEVADLFQTTQrvgtvve 70  human
1FHI         16 FLKTelsFALVNrkp---------------------vvpGHVLVCP-LRPverfh---dlrpdEVADLFQTTQrvgtvve 70  human
1HXP_A       66 NPDYtgtYVFTNdfaalmsdtpdapeshdplmrcqsargTSRVICFsPDHsktlp---elsvaALTEIVKTWQeqtael- 141 Escherichia coli
1HXQ_B       66 NPDYtgtYVFTNdfaalmsdtpdapeshdplmrcqsargTSRVICFsPDHsktlp---elsvaALTEIVKTWQeqtael- 141 Escherichia coli
1GUQ_A       66 NPDYtgtYVFTNdfaalmsdtpdapeshdplmrcqsargTSRVICFsPDHsktlp---elsvaALTEIVKTWQeqtael- 141 Escherichia coli
1EMS_A      312 FYSTphsFVFVNlkp---------------------vtdGHVLVSP-KRVvprlt---dltdaETADLFIVAKkvqamle 366 Caenorhabditis e...
ZP_00103673 444 VHRDqhvAAFVDlrq---------------------avdGHVLIVP-NRHvetly---eldedTAGRLMALAVrvarala 498 Desulfitobacteri...
NP_608634    51 VETDe-yVIFKDkyp---------------------aarLHYLAIP-KEHfds-------lkaLNKSHVGLVRrmeqgmm 100 fruit fly

Feature 1                      #        #   # #   
4RHN         77 ----lglkkGYRMVVNEGsdggqSVYHVHLHVLG 106 rabbit
6FIT         71 ---khfhgtSLTFSMQDGpeagqTVKHVHVHVLP 101 human
1FHI         71 ---khfhgtSLTFSMQDGpeagqTVKHVHVHVLP 101 human
1HXP_A      142 ----gktypWVQVFENKGaamgcSNPHPHGQIWA 171 Escherichia coli
1HXQ_B      142 ----gktypWVQVFENKGaamgcSNPHPHGQIWA 171 Escherichia coli
1GUQ_A      142 ----gktypWVQVFENKGaamgcSNPHPGGQIWA 171 Escherichia coli
1EMS_A      367 ---khhnvtSTTICVQDGkdagqTVPHVHIHILP 397 Caenorhabditis elegans
ZP_00103673 499 ---adgappGLNLWQSNGhaggqEVPHVHLHVQP 529 Desulfitobacterium hafniense
NP_608634   101 eflrsqnvdPKEAIVGFHlppfiSVRHLHLHGIF 134 fruit fly

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