1ZNC,1CNX,1FLJ,1KEQ,1KOP,1TB0,1URT,1Y7W,1RJ5


Conserved Protein Domain Family
alpha_CA

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cd00326: alpha_CA 
Click on image for an interactive view with Cn3D
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.
Statistics
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PSSM-Id: 238200
Aligned: 176 rows
Threshold Bit Score: 117.384
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitezinc binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1CNX: human carbonic anhydrase II binds zinc and benzenesulfonamide, contacts at 4.5 Angstrom
    View structure with Cn3D
  • Structure:1Y7W: a halotolerant carbonic anhydrase from Dunaliella salina binds Zinc and acetic acid
    View structure with Cn3D
  • Comment:zinc binding histidines and other residues found to be important for enzymatic activity

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1ZNC_A     30 KDRQSPINIVttKAKVDk----------------------------------------kLGRFFFsgydk---------- 59  human
1CNX       25 GERQSPVDIDthTAKYDp----------------------------------------sLKPLSVsydq----------- 53  human
XP_419221 398 GEYQSPINLNsrEAKYDp----------------------------------------sLLEVRLspnyv---------- 427 chicken
AAF46521   54 GRRQSPVNLEpqRLLFDp----------------------------------------nLRPMHIdkhr----------- 82  fruit fly
AAF46274   51 GRRQSPIDVVpdKLLFDp----------------------------------------yLRPLHIdkhk----------- 79  fruit fly
AAA20616   56 GRLQSPIDIQpdRLLFDasvkpvsyaelnffliiyltislklmryiftcahlfacnkklGTWNRIfganiakfrawvvyi 135 nematode
NP_495567  33 GQMQSPVNIDpsQLLYDp----------------------------------------hLMPINIegni----------- 61  nematode
XP_784796  55 GQRQSPIDLRaeSLVYDp----------------------------------------nLPQLEIdspa----------- 83  purple urchin
AAH69744   46 GEYQSPINLNsrEARYDp----------------------------------------sLLDVRLspnyv---------- 75  human
AAH87769   38 GDYQSPININsrEAMYDp----------------------------------------sLLEVRLtpsyv---------- 67  western clawed frog
Feature 1                         #                                     # # #           #     
1ZNC_A     60 ----------kqtwTVQNNgHSVMMLLen-----------kASISGggl--paPYQAKQLHLHWsdl--pykGSEHSLDG 114 human
1CNX       54 ----------atslRILNNgHAFNVEFdds--------qdkAVLKGgpl--dgTYRLIQFHFHWgsl--dgqGSEHTVDK 111 human
XP_419221 428 ---------vcrdcEVINDgHSIQIALks-----------kSVLIGgplprghEFELHDVRFHWgre--nqrGSEHTVNF 485 chicken
AAF46521   83 -----------isgLITNTgHSVIFTAgndtvanydgmqtpVNISGgpl--syRYRFHEIHMHYgln--dqfGSEHSVEG 147 fruit fly
AAF46274   80 -----------vsgTLHNTgQSLVFRVdkdt-------kqhVNISGgpl--ayRYQFEEIYIHYgte--nvrGSEHFIQG 137 fruit fly
AAA20616  136 iifhaqvpqlqvvsEFVNTgQMVRVRIgyss------kkpsVNITSgpl-ygyRYRVQRIDFHMgrk--nenGSEHTING 206 nematode
NP_495567  62 -----------veaVFENTgQLPVVTVkdlp------nrptINITGgpt-mpyRYKLHQISVHFgradegekGSEHTVDR 123 nematode
XP_784796  84 ----------etngIVNNTgRGISFFPdpa---------nvTYISRgpl--syRYRLVEIRLHFgge--nthGSEHTVGG 140 purple urchin
AAH69744   76 ---------vcrdcEVTNDgHTIQVILks-----------kSVLSGgplpqghEFELYEVRFHWgre--nqrGSEHTVNF 133 human
AAH87769   68 ---------vcrdcEVINDgHVVQILLks-----------kSVLKGgplprghEYELNEVRFHWgke--nqrGSEHTVNF 125 western clawed frog
Feature 1            #                                                                        
1ZNC_A    115 EhfaMEMHIVHEkekgtsrnvkeaqdpeDEIAVLAFLVeagtqvNEGFQPLVEALsnipk------------pemsTTMA 182 human
1CNX      112 KkyaAELHLVHWntkygdf--gkavqqpDGLAVLGIFLkvg-saKPGLQKVVDVLdsikt------------kgksADFT 176 human
XP_419221 486 KafpMELHLMHWnstlyssi-deavgkkHGIAIIALFVqig-keHVGLKAVTEILqdiqy------------kgksKTIP 551 chicken
AAF46521  148 YtfpAEIQIFGYnsqlyanf-sdalnraQGIVGVSILLqlgdlsNAELRMLTDQLeriry------------ggdeAFVK 214 fruit fly
AAF46274  138 YsfpGEIQIYGFnkelyhnm-seaqhksQGIVGLSLMVqigetpNPELRIITSTFnkvly------------rgfsTPIR 204 fruit fly
AAA20616  207 RrfpMEVQLVAYntdlypnf-tsaskspHGIAILSVLVdfgpetNQELIKLTIATasisy------------kdqrVQLA 273 nematode
NP_495567 124 VrfpAEIQLLAYnsalypnf-svamtspRGLLAVSVIVdigkttSVELRRLTVASqsiny------------kgqtTNLT 190 nematode
XP_784796 141 RafpGELQLIFFnddlydsy-gqaekspNGLAIMGLFIktngivNNTGRGISFFPdpanvtyisrgplsyryrlveIRLH 219 purple urchin
AAH69744  134 KafpMELHLIHWnstlfgsi-deavgkpHGIAIIALFVqig-keHVGLKAVTEILqdiqy------------kgksKTIP 199 human
AAH87769  126 KafpMELHLIHWnstlyrsl-eeamgkvHGIVIISLFVqig-keNIGLKAITEVLqdify------------kgksKTIP 191 western clawed frog
Feature 1                                             #                                       
1ZNC_A    183 ES----------------SLLDLLpkeeklrhYFRYLGSLTTP-TCDEKVVWTVFR----------EPIQLHREQILAFS 235 human
1CNX      177 NF----------------DPRGLLpes---ldYWTYPGSLTTP-PLLECVTWIVLK----------EPISVSSEQVLKFR 226 human
XP_419221 552 CF----------------NPNSLLpdpl-lrdYWVYEGSLTIP-PCSEGVTWILFR----------YPLTVSQVQVTIVL 603 chicken
AAF46521  215 RL----------------SIRGLLpdt---dhYMTYDGSTTAP-ACHETVTWVVLN----------KPIYITKQQLHALR 264 fruit fly
AAF46274  205 HI----------------SVRSLLpnt---dhYITYEGSTTHP-GCWESTVWIIVN----------KPIYITKQELYQLR 254 fruit fly
AAA20616  274 DF----------------EPWRLLpft---rdIITYEGSLTSP-GCHETVTWIILN----------QPIFIKKEHFEEWS 323 nematode
NP_495567 191 DF----------------QPSALLpkt---shYVTYEGSLTFP-GCHETVTWVILN----------NPIYITNDDLQIWN 240 nematode
XP_784796 220 FGgenthgsehtvggrafPGELQLiffn-ddlYDSYGQAEKSPnGLAIMGLFIKVVkltfrassipLLLPETKEYMTSVG 298 purple urchin
AAH69744  200 CF----------------NPNTLLpdpl-lrdYWVYEGSLTIP-PCSEGVTWILFR----------YPLTISQLQIEEFR 251 human
AAH87769  192 CF----------------NPNTLLpdpl-lrdYWVYEGSLTMP-PCSEGVTWILFR----------YPLTVSQTQIEEFR 243 western clawed frog
Feature 1                                    
1ZNC_A    236 Qklyydk--eqtvsmKDNVRPLQQLGQRTVI 264 human
1CNX      227 Klnfngeg-epeelmVDNWRPAQPLKNRQIK 256 human
XP_419221 604 KvtleygyelkvivcKYIYQDVMSVLREDPI 634 chicken
AAF46521  265 Rlmqgspd-hpkaplGNNYRPPQPLLHRPIR 294 fruit fly
AAF46274  255 Rlmqgses-tpkaplGNNARPVQSLHHRTVR 284 fruit fly
AAA20616  324 Hlylsmeg-aekvpvAPNFRKIQETNNRLVR 353 nematode
NP_495567 241 EmqktetkqpepsymTPAYRPLKSLNGRLVR 271 nematode
XP_784796 299 Sit----------tpRCTETVPWIIFNRPVY 319 purple urchin
AAH69744  252 RlrthvkgaelvegcDGILGDNFRPTQPLSD 282 human
AAH87769  244 RlrthikgadlpdgcDGLMADNFRPTQPLSD 274 western clawed frog

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