1OVA,1ATT,1C5G,1IMV,1JMJ,1JRR,1K9O,1QLP,1QMN,1SEK,1XQJ


Conserved Protein Domain Family
SERPIN
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cd00172: SERPIN (this model, PSSM-Id:238101 is obsolete and has been replaced by 381000)
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SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants have been associated with blood clotting disorders, emphysema, cirrhosis, and dementia.
Links
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Statistics
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PSSM-Id: 238101
Aligned: 91 rows
Threshold Bit Score: 194.394
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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reactive center
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop
Evidence:
  • Comment:depending on the conformational state, the RC loop is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form.
  • Structure:1QLP_A; active conformation-loop out; P1-P1' cleavage site: Met-Ser.
    - View structure with Cn3D
  • Structure:1K9O_I; active conformation - complexed; serpin-trypsin interface
    - View structure with Cn3D
  • Structure:1ATT_B; loop cleaved and partially inserted.
    - View structure with Cn3D
  • Structure:1C5G_A; latent-uncleaved and inserted.
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  • Structure:1QMN_A; delta form-natural occurring mutant, L-55-P.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1OVA_A      7 ASMEFCFDVFKELKvhh----anENIFYCPiAIMSALAMVYLGAkdsTRTQINKvvrfdklpgfgdsieaqcgtsvnvHS 82  chicken
1QLP_A     29 NLAEFAFSLYRQLAhqs----nsTNIFFSPvSIATAFAMLSLGTkadTHDEILEglnfnlt----------eipeaqiHE 94  human
1QMN_A     30 ANVDFAFSLYKQLVlka----pdKNVIFSPpSISTALAFLSLGAhntTLTEILKglkfnlt----------etseaeiHQ 95  human
P05155    145 ALVDFSLKLYHAFSamk---kveTNMAFSPfSIASLLTQVLLGAgenTKTNLESilsypk-------------dftcvHQ 208 human
P46202     53 NYKAFAQELFKTLLied----prKNMIFSPvSISISLATLSLGLrsaTRTNAIDvlerdlr----------nlrvwdkHQ 118 pig
AAC63406   50 SQGDFGFQFFHKLGeas----pgQNVLFSPlTTSAALMMLLAGSgdkTETQLTNalrlqf------------lrdpnpQA 113 sea lamprey
Q9UK55     78 ETSNFGFSLLRKISmr-----hdGNMVFSPfGMSLAMTGLMLGAtgpTETQIKRglhlqalk---------ptkpgllPS 143 human
AAM52988   47 NNQKFALSLYKQLPqpk----rgKNLIFSPlGIIVPLVLLAFQDkpkARHQVLQdlgftvt----------galdtkaAS 112 Norway rat
CAG00125   53 LNTLLAFEPYQALAsaepeapqqPNILFSPlGLASAAALLSRVSgpeRRSQALTllglaags--------peqsvedtLS 124 Tetraodon nigrovir...
AAH81282  332 SITSFSIDLLKEIDpes----kkPSVVMSPfSIALGLLQLSLGSgkeMEEKLMKtlh------------------vesLH 389 African clawed frog

Feature 1                                                                                     
1OVA_A     83 SLRDILNQItkpndvysfSLASRLYAEERYPILPEYLQCVKelyrggLEPINFqta-adqARELINSWVESQtngiIRNV 161 chicken
1QLP_A     95 GFQELLRTLnqpdsqlqlTTGNGLFLSEGLKLVDKFLEDVKklyhseAFTVNFgdt--eeAKKQINDYVEKGtqgkIVDL 172 human
1QMN_A     96 SFQHLLRTLnqssdelqlSMGNAMFVKEQLSLLDRFTEDAKrlygseAFATDFqds--aaAKKLINDYVKNGtrgkITDL 173 human
P05155    209 ALKGFTTKGv--------TSVSQIFHSPDLAIRDTFVNASRtl--ysSSPRVLsnn-sdaNLELINTWVAKNtnnkISRL 277 human
P46202    119 ALQHLVEMLhelekkkqlKHKDIFFIDRNKKMNQMFLKEIDrvykvdIQMIDFkdk--ekTKKAINQFVADKidkkAKNL 196 pig
AAC63406  114 SFQALVSKLhhgr--dstNIAARIFTAKHATIKQQFLDAVEkyykakPQKLIGnm---keDVALINKWVAEKteghIPDF 188 sea lamprey
Q9UK55    144 LFKGLRETLsrnl-elglTQGSFAFIHKDFDVKETFFNLSKryfdteCVPMNFrna--sqAKRLMNHYINKEtrgkIPKL 220 human
AAM52988  113 EYGKLLSNLlhtk-ncgiYTGSLLFIDKTLKPAKTFVKLANssynsnVVLISFgny--glAQKQIDLAIRARthgkITKL 189 Norway rat
CAG00125  125 ALTNLLHNLtlp----eeGEGAGAWGGAGDNGSSTDAAEAAth--agSQLKVWsrlqadgKQADHQSFPSGNqrggSSNA 198 Tetraodon nigrovir...
AAH81282  390 CLHNKLKTVrkeltksilRTATRIYLKKGFKIKKSFLKRSEkw--ygSKPLNLant-kkqNLDSINKWVKDVtegqIPQF 466 African clawed frog

Feature 1                                                                                     
1OVA_A    162 LqpssvdSQTAMVLVNAIVFKGLWEKAFkdedTQAMPFRVTeqesKPVQMMYQIg--lFRVASMas--ekMKILELPFAs 237 chicken
1QLP_A    173 Vke--ldRDTVFALVNYIFFKGKWERPFevkdTEEEDFHVDqvttVKVPMMKRLg--mFNIQHCkk--lsSWVLLMKYLg 246 human
1QMN_A    174 Ikd--ldSQTMMVLVNYIFFKAKWEMPFdpqdTHQSRFYLSkkkwVMVPMMSLHhl-tIPYFRDee--lsCTVVELKYTg 248 human
P05155    278 Lds--lpSDTRLVLLNAIYLSAKWKTTFdpkkTRMEPFHFKns-vIKVPMMNSKk---YPVAHFidqtlkAKVGQLQLSh 351 human
P46202    197 Ith--ldPQTLLCLVNYVFFKGILERAFqtnlTKKEDFFVNektiVQVDMMRKTe--rMIYSRSee--llATMVKMPCKe 270 pig
AAC63406  189 Vke--lpEELQLFIVSAIFFKGKWLKPFqvesTSPRPFHLSpsneTQVPTMFASgy-pIKKGRHps--lpVTVAKIQFQg 263 sea lamprey
Q9UK55    221 Fde--inPETKLILVDYILFKGKWLTPFdpvfTEVDTFHLDkyktIKVPMMYGAg--kFASTFDkn--frCHVLKLPYQg 294 human
AAM52988  190 Lri--lkPPTNLFLANYNFFKGKWKYPFnrkhTXMRYFWLEdgtkTLVPMMQRVg--wFQLQYFsq--mhSYVLQLPFTc 263 Norway rat
CAG00125  199 Sdt---dSQVSDKLNLRSYAYFKGRLPFerrhTVRRSFQLNatasVEVAMMFRDdssdVRMLYDtn--csATVVQLAQSe 273 Tetraodon nigrovir...
AAH81282  467 Lsd--lpQNVALILLNAMHFKGIWKNTFdpslTSEDTFYINdddgIQVEMMNAPky-pFSWLHLea--ieGHVAKLQFKg 541 African clawed frog

Feature 1                                                                                     
1OVA_A    238 gtMSMLVLLPDev-sgLEQLESIInf-eKLTEWTssnvme-erkikVYLPRMKMEEK-----YNLTSVLMaMGITdvfss 309 chicken
1QLP_A    247 -nATAIFFLPDeg--kLQHLENELth-dIITKFLenedr---rsasLHLPKLSITGT-----YDLKSVLGqLGITkvfsn 314 human
1QMN_A    249 -nASALFILPDqd--kMEEVEAMLlp-eTLKRWRdslef--reigeLYLPKFSISRD-----YNLNDILLqLGIEeafts 317 human
P05155    352 -nLSLVILVPQnlkhrLEDMEQALsp-sVFKAIMeklemskfqptlLTLPRIKVTTS-----QDMLSIMEkLEFFdfsyd 424 human
P46202    271 -nASIILVLPDtgkfdFALKEMAAkr-aRLQKTNe-----------LQIGALSCAQDqdhlqDRFKHLLPkIGINdiftt 337 pig
AAC63406  264 -nTSLLLFVPDavstnLSALESSLss-qLVTTLVeetlv--qkkidLYLPLISLDVE-----SNIEQKLTdIGLGdlfkt 334 sea lamprey
Q9UK55    295 -nATMLVVLMEkm-gdHLALEDYLtt-dLVETWLrnmkt---rnmeVFFPKFKLDQK-----YEMHELLRqMGIRrifsp 363 human
AAM52988  264 -sISGVFFLPDdg--kFEESEKALle-qSFETWIqpfpm---skrwLFFPKFSIPVAlh--lEKLKHVNSnIKLFsehmd 334 Norway rat
CAG00125  274 -rLAWLLLLPRa---eLQSLEGCLye-gRMRFWLsnlkp---ghaeILFPKLQLRRS-----YNLEKLLRsSGASslfsd 340 Tetraodon nigrovir...
AAH81282  542 -nMSFVILMPFsstwdLSKLLANFnqtdLYSRFSkek------vsnLKMPKLNLDYK-----LELNEALTnLGLGqlftn 609 African clawed frog

Feature 1                                   ####                     ######                   
1OVA_A    310 sanlsg-issaeslkisQAVHAAHAEINEaGREVVGSAeagvda-----asvseeFRADHPFLFCIKHiatnAVLFFGRC 383 chicken
1QLP_A    315 gadlsg-vteeaplklsKAVHKAVLTIDEkGTEAAGAMfleaip-----msippeVKFNKPFVFLMIEqntkSPLFMGKV 388 human
1QMN_A    318 kadlsg-itgarnlavsQVVHKAVLDVFEeGTEASAATavkitlls-alvetrtiVRFNRPFLMIIVPtdtqNIFFMSKV 395 human
P05155    425 lnlcg--ltedpdlqvsAMQHQTVLELTEtGVEAAAASaisva-------rtllvFEVQQPFLFVLWDqqhkFPVFMGRV 495 human
P46202    338 kavtw---nttrtstilEAVHHAVIEVKEdGLTKNAAKdkdfwkvpvdkkevpvvVKFDRPFFLFVEDeitrRDLFVAKV 414 pig
AAC63406  335 pdlsk---isdiplrvsKVIHRATMTLNEeGVKATAATgimislm---svqhseeLKVDRPFVFLIRDdetgALLFVGRV 408 sea lamprey
Q9UK55    364 fadlselsatgrnlqvsRVLQRTVIEVDErGTEAVAGIlseita-----ysmppvIKVDRPFHFMIYEetsgMLLFLGRV 438 human
AAM52988  335 lsrit---lqkapltvsTAVHRVELTVNEdGEEKDESQpepd----------latLHFNRSFLLLILDetsnSLLFMGKV 401 Norway rat
CAG00125  341 lpgq----seektprlqEASHEVMLEVEEaKLEEAGSYdvpldf------smpprITFNRPFILMVYDrvtgLVLLLGRI 410 Tetraodon nigrovir...
AAH81282  610 pdlsg---isdeplfvsSIQHQSCLELNEeGVEASAATavits-------rshsiYRIDRPFIFFLFEdtmgLPLFMGQV 679 African clawed frog

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