1QQK,1G82,1IJT,1RML,1BFC,1CVS


Conserved Protein Domain Family
FGF

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cd00058: FGF (this model, PSSM-Id:238015 is obsolete and has been replaced by 466989)
Click on image for an interactive view with Cn3D
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate embryogenesis, and has neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active. FGFs have internal pseudo-threefold symmetry (beta-trefoil topology).
Statistics
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PSSM-Id: 238015
Aligned: 31 rows
Threshold Bit Score: 124.648
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heparin bindingreceptor
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:heparin binding site (glycine box) [chemical binding site]
Evidence:
  • Comment:binding site for anionic heparin sulfate contains conserved positively charged residues
  • Citation:PMID 1849658
  • Structure:1BFC; basic fibroblast growth factor with bound heparin
    View structure with Cn3D
  • Citation:PMID 1702556
  • Comment:motif has been described as glycine-box in the literature
  • Comment:9843417

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1QQK_A     13 RRLFCRt-QWYLRIDKRGKVKGTQEMrnSYNIMEIRTVA-VGIVAIKGVeSEYYLAMNKEGKLYAKK-----ECNEDCNF 85  Norway rat
1BFC       22 KRLYCKngGFFLRIHPDGRVDGVREKsdPHIKLQLQAEE-RGVVSIKGVsANRYLAMKEDGRLLASK-----SVTDECFF 95  human
2494465    31 VQVLIH--NRYLAVRSDGTVGGTTYAssLDTVLQRIAIA-HGRILLRNAvSCMYVCLDRCGAMYASA-----ALSSDCIL 102 Orgyia pseudotsuga...
1169678    30 GQLFIN--RQFLAVNPDGAVYGTIESdnVDTIFKRVAVD-RNRIVIQNAiTCVYLCMDRCGQLYGSK-----TLSKDCFM 101 Autographa califor...
NP_203194  31 VQVFVH--NRYLAVRLNGTVEGTEDAfdVDTMLQRVSFR-DGRILLRNAiTCMHVCLDRCGVMYSTN-----AMSYDCFL 102 Epiphyas postvitta...
3006120    29 IQMFVK--NQYIAVDGNGDVMGCRDRtaSRTVFYRISIS-HNLLSLVNSvSCRYVCINACGYVYTLAmngagGISQDCLL 105 Spodoptera littora...
NP_037798  35 VHIFLN--HYFLQMNADGVVDGALTDasNQTIWHRIARP-DGMMLLRSSiYCTYLCVNECGYGYSAL-----LPNGECLW 106 SeMNPV
9631123    25 VQIGIN--RQLLTCFANGTVGGSTDEraDGTAWRRWAAK-PREVLIRSAaTCAFVCLDDCGFLYTAAe----APNKECLF 97  Lymantria dispar n...
NP_613134  36 VQIFIN--HHLLRMNLDGIVNGTQTGesSETVWHRISQS-DGILLRSSL-YCNYACINECGYGYSAL-----IPNNECLW 106 Mamestra configura...
2494455    54 YQLYSRtsGKHVQILDNKKINAMAEDgdVHAKLIVETDTfGSRVRIKGAaTGFYICMNKKGKLIGKSn----GKGKDCVF 129 chicken
Feature 1                                 ##    #   #          #        
1QQK_A     86 KELILENHYNTYASakwthsggemFVALNQKGLPVKGKKtkk-----eqKTAHFLPMA 138 Norway rat
1BFC       96 FERLESNNYNTYRSrky----tswYVALKRTGQYKLGSKtgp-----gqKAILFLPMS 144 human
2494465   103 NEVMLENNYDVMFKiyng---kktYVALDNTGNPRRVQLprqrp-lrmmNVYTFIMRI 156 Orgyia pseudotsugata multicapsid nuclear...
1169678   102 REFLEKNNYNTYYKvydr---kltYVALKNDGTPRKLQIsksr---klgKLSVYAMAL 153 Autographa californica nucleopolyhedrovirus
NP_203194 103 KENYTENNYSVMYKiykr---krtYVALNNRGRARRVQLpmrr---tlrKMSQYALLL 154 Epiphyas postvittana nucleopolyhedrovirus
3006120   106 REHMTESYYNWYYRednd---trsFLALNKYGRTKRVRIksddvlhnniNSINVITGQ 160 Spodoptera littoralis nuclear polyhedros...
NP_037798 107 SEIYDDFNNRFIVKrfen--nrtaYLALNAAGKLKRVVLlkkeklmdafEQTHVFIKN 162 SeMNPV
9631123    98 VEELSENHYSYLYRvhdr---sriYLALGANGKSRRVVApvd-----epLADHGNPTS 147 Lymantria dispar nucleopolyhedrovirus
NP_613134 107 TEQYDEHNYRFINKkfgn---rtaYLSINLEGKLKRTVLlrketlgnkfEQSHVTLKD 161 Mamestra configurata nucleopolyhedrovirus
2494455   130 TEIVLENNYTALQNaky----egwYMAFTRKGRPRKGSKtrq-----hqREVHFMKRL 178 chicken

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