1DF0,1KFU


Conserved Protein Domain Family
CysPc

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cd00044: CysPc 
Click on image for an interactive view with Cn3D
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Statistics
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PSSM-Id: 238004
Aligned: 36 rows
Threshold Bit Score: 207.184
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic site
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:has an active site cysteine; catalysis proceeds through a thioester intermediate.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1DF0_A     34 TLRNECLEAGALFQDPSFPalpsslgfke-----------------lgpyssktrgIEWKRPTEICAD----------PQ 86  Norway rat
CAB95475  167 DTLAACIAKKTKFVDLIFPpgqeslqi---------------------gtphklkvIPWERPSMYLSDena-----lhAR 220 Trypanosoma brucei
NP_055111 214 TTSKINGIEYVPFMNVDLRerfaypmpfcdrw-----------gklplspkqkttfSKWVRPEDLTNN----------PT 272 human
7507052   218 TTSNINNKLYVPFHNYDKVnefkgqqgkftdpe----------gkisltqkqrmklKCWKRVSELFEN----------PT 277 Caenorhabditis ele...
AAG48627  249 QLLEHCTANQVPYIDCSFRpcdrslsrp-------------------dvdvhnlqsLPWRRPCDYIPKsql----devRL 305 Trypanosoma brucei
AAG48626  201 ELLKLCSDSLVRYADINFLpsnsmfsrl-------------------dgdgrfiqpVEVRRPSEFAQCde------enID 255 Trypanosoma brucei
CAA91013  102 TREDIILLQGAKLNGFIFPpwkaepsltefetgtngdvlftdkpdlhlsnlqrdifAGWKRPHELLSGqvddagmplnPV 181 Aspergillus nidulans
AAD28472  104 TREEIILLEGAKLNGFIFPpwstspgsdefkredges-pftdkpdlhlsypqrkvfDGWKRPSELLAKdtedvytkvvPV 182 Aspergillus oryzae
CAC14603   75 LAEKIVYLSSRTNYGYALPweyatpvsalkksddl-----yvdatdgglrqsqhrdVSWLRIPHVFASs--------dAV 141 Yarrowia lipolytica
P25806    129 RGQDGLERILESFNDYDMPpeekeeaapkakkaaqkldiddlreqalssttitkeiSKIILPTKNLRDdnntvhqyreVG 208 Porphyromonas ging...
Feature 1                         #                                                           
1DF0_A     87 FIIGga--trTDICQGALGDSWLLAAIASLTLNEE------ILARVVPLdqsfq---------enyaGIFHFQFWQYg-e 148 Norway rat
CAB95475  221 LFRNni--hpGNIDEGELGDSWFTGALACMAEFPD------RVRDMFRHprsieeg-----knereiGAYRVTFNKDg-w 286 Trypanosoma brucei
NP_055111 273 MIYTvs---sFSIKQTIVSDCSFVASLAISAAYERrfn-kkLITGIIYPqnkdge------peynpcGKYMVKLHLNg-v 341 human
7507052   278 IIFSid---cHTIKQTVISDCSFISSLSIAALYEKrfk-kqLVTSIIFPqdangk------piynpaGKYMFKFHLNg-a 346 Caenorhabditis ele...
AAG48627  306 FRRSia---pSHVTQGELGDSYFTSAVACLAEMPD------KIRDLFRHpvspsvg-----kaerrvGAYWVTLNCGg-w 370 Trypanosoma brucei
AAG48626  256 AVRGvv--lsSCVEAGTLGDSWFVSALSLLATDEE------RVKAMFASttpa----------ekqmGAYRVLLNKDg-w 316 Trypanosoma brucei
CAA91013  182 MTVSg----nTDLVQDVLTDCSVVASLCATTSRSErglddtLLPIVYPCihnsmk------sdispsGKYIFRFYFNg-c 250 Aspergillus nidulans
AAD28472  183 MSVPg----kTDLVQDMLTDCSVVASLCATTSMLErgqcthFLPMIYPSrgssq---------pspsGKYIFRFYFNg-c 248 Aspergillus oryzae
CAC14603  142 FTWSg----fETLYQDGLENCSFVASLLSIGVMEKrcn-ysLLKEALLDkssnhhl-----gtppssGRYDIKLFINg-c 210 Yarrowia lipolytica
P25806    209 FQSNgahnlwDTVVQGIAGDCYMLAALSAIAWVWPa-----LLNMDVDImsnqdewrlyryfigrskQTYANRPSGSgts 283 Porphyromonas ging...
Feature 1                                                                                     
1DF0_A    149 WVEVVVD--DRLPTKDGE--LLFVHSaeg---sefWSALLEKAYAKINGcyeal-------sggaTTEGFEDFTGGIAEW 214 Norway rat
CAB95475  287 WTNVIID--DYLPCSGGH--PMFARSygdp--melWVSLAQKAYAKLHGgygfl-------vvgdPLRALQDLTGFPCSS 353 Trypanosoma brucei
NP_055111 342 PRKVIID--DQLPVDHKGe-LLCSYSnnk---selWVSLIEKAYMKVMGgydf--------pgsnSNIDLHALTGWIPER 407 human
7507052   347 WRKVLID--DYFPVDENNr-MMCSQTenk---gelWVSLLEKAYMKVMGgydf--------pgsnSNIDLNALTGWIPER 412 Caenorhabditis ele...
AAG48627  371 WRPTVID--DYLPAYREG--PEYAHCavdf--rrlWVALLEKAYAKIHHsysni-------asgdPLDPLQDLTGFPITR 437 Trypanosoma brucei
AAG48626  317 WKNILVD--DFLPTVGGV--PCYARCidds--gelCLSLLQKAYAKLYGfyasi-------tggdTFFALQNFTGAPVYR 383 Trypanosoma brucei
CAA91013  251 FRKVVID--DRLPSSKTSr-SLYMIDrnhr--nfmWPALVEKAYLKLRGgyef--------pgsnSGTDLWVLTGWIPEQ 317 Aspergillus nidulans
AAD28472  249 FRKVIID--DRLPSSKTSrsLHVIDRknp---nflWPALVEKAYLKLRGgydf--------pgsnSGTDLWVLTGWIPEQ 315 Aspergillus oryzae
CAC14603  211 DRRITID--DRFPIREPS--LPNMYLrsytnptlvWPALLEKAFMKVLDgydy--------agshAGGDTFVLCKWFPEF 278 Yarrowia lipolytica
P25806    284 TNEILQEgyYKVPIFARSr-YWFNGEy--------WPALFEQAYANWKFpndskynailqigggwPEEALCELSGDSWFT 354 Porphyromonas ging...
Feature 1                                                                             #       
1DF0_A    215 YELrkp---------ppnLFKIIQKALEKGSLLGCSIDItsaads----------------eavtyqKLVKGHAYSVTGA 269 Norway rat
CAB95475  354 FNTafenak---mnggeeLFVHLLQYGQTSYQTILTVPTrgalklqga-----------sveayeatGLLPGHVYTVLSV 419 Trypanosoma brucei
NP_055111 408 IAMhsdsqt---fskdnsFRMLYQRFHKGDVLITASTGMmteae-------------------gekwGLVPTHAYAVLDI 465 human
7507052   413 IELsdtska----dpdevFRKLFDRFHRGDCLITLATGKmtedm-------------------qkrsGLVETHAYAVIDI 469 Caenorhabditis ele...
AAG48627  438 FDTdwesav----ngddkLFKRLVMYNKRGYITVLYTPPpaalkaaqpsdtspttearkprvtckelGLQAHSGYSVLQV 513 Trypanosoma brucei
AAG48626  384 FDKawrdaat-deekknaLIQKITGYVEAHNPVILSVPTgrkaa------------------tavanGLREGYSYALLSV 444 Trypanosoma brucei
CAA91013  318 VFLhsdev-----tadqiWSDLFKSFHSGDVLLTIGTGKltere-------------------qkelGLVSEHDYAILDM 373 Aspergillus nidulans
AAD28472  316 VFLhnddv-----tgdqlWKRLYRSFHQGDVLLTIGTGEltere-------------------qrelGLVSEHDYAILDM 371 Aspergillus oryzae
CAC14603  279 VSLtsyhd------tnglWRYIYDSWLQGDVLLCLGTGSfsree-------------------adykGLLGEHDYAVLEL 333 Yarrowia lipolytica
P25806    355 SSGklmlssftdlsllnfMKSMCYSWKTIKPMVIVTPCWeplp--------------------pmmpGIAAYHAYTVLGY 414 Porphyromonas ging...
Feature 1                     #                                                             
1DF0_A    270 EEVessgslQKLIRIRNPWGqvewtgkwndncpswn-----tvdpevranlterqeDGEFWMSFSDFLRHYSRLEICN 342 Norway rat
CAB95475  420 MPFpe--ynLRLLLLRNSWAnhskhrwngawkrgsek--wkqypgvaaacagacdaDGVLCVEWSEALALFAGCGVCF 493 Trypanosoma brucei
NP_055111 466 REFk----gLRFIQLKNPWShlrwkgrysendvknwtp-elqkylnfdprtaqkidNGIFWISWDDLCQYYDVIYLSW 538 human
7507052   470 RCVe----tKRLLKVKNPWThsrwkgnfsdkdkvnwta-kmknalafdpevaaekdDGIFWIDYESVRHFFDVIYVNW 542 Caenorhabditis elegans
AAG48627  514 KCFee--mgLFLLQVRNPWStgeewkgrwsksdklweeypsvqsacfpsgmespkdDNMFWLQWSDALNVFAGGGVCH 589 Trypanosoma brucei
AAG48626  445 HNFpe--enITLLKMFNPWEpampwsgqwregsdkwt---ehseiqsscepcfeahDGIFFIEWSEAVEVFNGCGVLY 517 Trypanosoma brucei
CAA91013  374 KELk----gRRQFLIKNPWAgtdavypalfad-------------pgpfpnspflsPGTFWMDCEMVLQNFENLYLNW 434 Aspergillus nidulans
AAD28472  372 KESk----gRRQLLVKNPWAgadtapgdngsls----------asqdlphnppsfePGTFWMDCEKLLQHFENLYLNW 435 Aspergillus oryzae
CAC14603  334 REIqdgcntAHILRIRDPLLfgpfsnpknplveesn-----rlaklvdgknvdmasRGEIWMDFNQATREYQSLYLNW 406 Yarrowia lipolytica
P25806    415 TVSn----gAYYLIIRNPWGvteptgdgvlskrdw------vihfdnmkwfnlskdDGIFALRLDKVRENFWYIAYMY 482 Porphyromonas gingiv...

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