Conserved Protein Domain Family
PurF

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COG0034: PurF (this model, PSSM-Id:223112 is obsolete and has been replaced by 439804)
Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]
Statistics
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PSSM-Id: 223112
Aligned: 53 rows
Threshold Bit Score: 359.606
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6647716   54 PREECGVFGVWAPGE-L-VAKLTYFGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLA-AMEG-HVAIGHC 129 Mycobacterium leprae
21759385   7 MREKCGIFGVS-SED---AVRKTYYGLIALQHRGQEGAGISVWNGR-IRTIKGHGLVSEVFDENSLN---LAsNIAIGHV 78  Pyrococcus abyssi
18311787   1 --MSAGLFAIYSFQGpVnLYPFVYYGLRAMANRGDVAVAYVLGEG--------------------------------GDL 46  Pyrobaculum aerophilum
18311794   1 ---MCGIGGAWGGR----AGERVRRMAPWLMHRGHEGVGYAYMKG---------GEIALGEPRDDAEg-------ALVHT 57  Pyrobaculum aerophilum
6647708    6 MKEKCGIFGAY-SQD---ATKKTYYGLMALQHRGQEGAGISVWDGD-IRTVKGHGLVSEVFKGGSIRr--LNgNPVIGHV 78  Pyrococcus horikoshii
15926656   7 LNEECGVFGIWNHPE---AAQLTYMGLHSLQHRGQEGAGIVVSDQNELKGERGLGLLTEAINDD-QMeRLKGyQHAIGHV 82  Staphylococcus aure...
15674270   8 LNEECGVFGIWGHPQ---AAQVTYFGLHSLQHRGQEGAGIVSNDNGKLYGYRNVGLLSEVFKNQSELdNLTGnA-AIGHV 83  Streptococcus pyoge...
15897546   4 IRDKCGVFAVSSPKEv--NIQLVVEGIRLLQHRGQESAGIAYAENGEILTIKGSGLVDEVFKENLNK--Fi--KNGIGHV 77  Sulfolobus solfatar...
15644003   1 ---MCGIAGVWNVKD---AFSVLHDVLLGLQHRGQESVGV-VVDG--FKTIKGKGLVDTVLTEDRWE----DaEKGIGHV 67  Thermotoga maritima
16800946   8 LNEECGIFGIWDHPN---AAEITYYGLHSLQHRGQEGAGIVSTDGETLKGHRNLGLLADVFKHG-ELdDLKGkA-AIGHV 82  Listeria innocua
6647716  130 RYSTTGDTTWENAQPVFRNIAaGSGVALGHNGNLVNTAELAARARDAGLIakrcpAPATTDSDI----LGALLAHGAADS 205 Mycobacterium leprae
21759385  79 RYSTSG--SLSEVQPLEVRCC-GYELAIAHNGTLTNFIPLRRLYEGMGIK-----FHSSVDTEVigisFLNHYSQVK--- 147 Pyrococcus abyssi
18311787  47 RRVEVDFS-----KEAAGEAR-----GIAAVGCVSTEECCR----------------ATEEGVY------CAFGRDR--- 91  Pyrobaculum aerophilum
18311794  58 RYSTSGEY-GVQLQPVLAKYR-DLEIAVVFNGTVVN-------YKRLGVE------SPSFDGDA----LAKALAREIWER 118 Pyrobaculum aerophilum
6647708   79 RYSTSG--SLSEVQPLEVECC-GYKVSIAHNGTLTNFLPLRRFYESRGFK-----FRSSIDTEViavsFLNHYSELK--- 147 Pyrococcus horikoshii
15926656  83 RYATSGNKGIENIQPFLYHFY-DMSVGICHNGNLINAKSLRQNLEKQGAI-----FHSSSDTEV----IMHLIRRSKa-P 151 Staphylococcus aure...
15674270  84 RYATAGSADIRNIQPFLYKFH-DGQFALCHNGNLTNAISLRKELEKQGAI-----FNASSDTEI----LMHLIRRSHn-S 152 Streptococcus pyoge...
15897546  78 RYSTSGKSSIEEAQPLGDSKI-----VVAFNGTISN-------YYQFGSF-------R-VDTEF----IYKFFKQKLAFR 133 Sulfolobus solfatar...
15644003  68 RYSTAG--SLEDIQPIVAFTR-KGRLAIAHNGNIPNGEKWIEMLKEKGAV-----FQSSLDSEV----FLHLISMSEG-- 133 Thermotoga maritima
16800946  83 RYATAGQKNLGNVQPFLFHFH-SSSLALAHNGNLVNAKTLRRELEEEGAI-----FQTSSDTEV----LAHLIKRSHt-G 151 Listeria innocua
6647716  206 TLEQAALELLPTVRGAFCLTFMDEN-TLYACRDPYGVRPLSLGRLDRG---WVVASETAGLDIVGASFVRDIEPGELLA- 280 Mycobacterium leprae
21759385 148 DEFEAMRRVFEEVKGAYSILILFDG-KIIAARDPVGFRPLVFGE-GDG---YYFASEDSALRMFGLETRDVLP-GEVFV- 220 Pyrococcus abyssi
18311787  92 -----VKLG--APSGDTVYVGLLKN-GVVYAYRPPRLWHLAVGAH--GfdfAIIATESSVIEILGGDLRRSLKGGELLKi 161 Pyrobaculum aerophilum
18311794 119 GVEQGVISVYSKIVGAATLLALTPW-GLLAVRDPRGIRPLAYRLYGEG---VAFSSETVALGGG-----QEVAPGLAVL- 188 Pyrobaculum aerophilum
6647708  148 DEFEAMSRVFEEVKGAYSVLMLFNG-KLIAVRDPVGFRPLSFGA-GDG---YYFSSEDSALRMFCTNIRDVSP-GEVIV- 220 Pyrococcus horikoshii
15926656 152 TFEEALKESLRKVKGGFTFAILTKD-ALYGAVDPNAIRPLVVGKMKDGt--YILASETCAIDVLGAEFVQDIHAGEYVV- 227 Staphylococcus aure...
15674270 153 SFMGKVKEALNTVKGGFAYLLMTEN-KLIAALDPNAFRPLSIGQMQNGa--WVISSETCAFEVVGAKWVRDVEPGEVIL- 228 Streptococcus pyoge...
15897546 134 SIPDTVKEFMKVVDGGYSVAILLNDeEIVVFRDPKGFHPVVLGFL-EGs--LIVSSEDSVIRQLGGSVLKHILPSEMIIm 210 Sulfolobus solfatar...
15644003 134 DLKESIVKALKKVPLAYSLLILHEE-FLAAARDPYGVRPLFYGKYGDG---IVVASEDAALKAIGVEDIEEVPSGTVVF- 208 Thermotoga maritima
16800946 152 DFVEDLKVALNKVKGGFAYMLLTED-TMYAALDPNGFRPLSIGRIGDs---YVVASETCAFETVGAEFVRDVEPGELII- 226 Listeria innocua
6647716  281 -IDADGVRSTRFANP-TPKGCVFEYVYLARPDSTLAGRSVHGTRVEIGRRLARECPVEADLVIGVPESGTPAAVGYAQES 358 Mycobacterium leprae
21759385 221 -IDGESYESKVLARE-KHAYCVFEYIYFARPDSTLNGINVYCARYRMGVELARESPAEGDVVIAVPDSGRTAALGFAHES 298 Pyrococcus abyssi
18311787 162 hKFG--VESAGGGPPr--EICAMELVYASRLDSVIDGVEIAEVRAKLGEALGKKAGRAD-VVIGVPDTGLYYAAWAARAA 236 Pyrobaculum aerophilum
18311794 189 -YGKR-MAFWKIPPGe-aKICAMELVYFAHPASILGNRLVADVRRALGRALAEVETHNFDVVAYVPETARTAAEAFAEAL 265 Pyrobaculum aerophilum
6647708  221 -VKDGEAESKIVGRS-EHAYCVFEYIYFARPDSIINGISVYWARYRMGVELARESPAEGDVVIAVPDSGRTAALGFAHES 298 Pyrococcus horikoshii
15926656 228 -INDKGITVKSYTHHtTTAISAMEYIYFARPDSTIAGKNVHAVRKASGKKLAQESPVNADMVIGVPNSSLSAASGYAEEI 306 Staphylococcus aure...
15674270 229 -IDDRGIQCDRYTDEtQLAICSMEYVYFARPDSTIHGVNVHTARKNMGKRLAQEFKQDADIVIGVPNSSLSAAMGFAEES 307 Streptococcus pyoge...
15897546 211 kNGKi-LYDKVIYEEknyATCSFEYIYFARPDSNIDGHSVYLARIRLGELLAEKHPANGDIVVPVPDSSRPIALGFSRKS 289 Sulfolobus solfatar...
15644003 209 -FSNKGTETVRFSKK-EKRFCSFEFIYFARPDSHFLDQSVHIARYRMGEELYRENPIEADVVVPVLDSGLSGAMGFSSAS 286 Thermotoga maritima
16800946 227 -INNDGLRIEKFTENvTHSICSMEYIYFARPDSNIAGINVHSARKRSGKRLAKEAFIDADVVTGVPDSSISAAIGYAEEA 305 Listeria innocua
6647716  359 GISYGQGLMKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIRGKRLIVVDDSVVRGNTQRALVRMLR-EAGAVELHVRIA 437 Mycobacterium leprae
21759385 299 GIPYMEGLIKNRYIGRTFIMPSG--RGLKVKLKLSPVREVVNGKRVVLVDDSIVRGTTMTRIVKMLR-DAGAREVHVRIA 375 Pyrococcus abyssi
18311787 237 G-AWHAPGFVSTIKKRSALLDEVKERISAIQLKANVVRHAVAGKRVLVVDDSIISGLTLRHIAQLIRvKAGAKEVHAATA 315 Pyrobaculum aerophilum
18311794 266 GKPLVDAVVKNRFAGRVFITPPH-LRNPGDAFR--AVPQLVEGRRVALVDDSLIRGTNIRTVVRLLK-EAGAREVHVRIA 341 Pyrobaculum aerophilum
6647708  299 GIPYMEGLIKNRYIGRTFIMPSG--REIKVRLKLSPVKEVIKGRRIVLVDDSIVRGTTMKNIVKMLR-DAGAREVHVRIA 375 Pyrococcus horikoshii
15926656 307 GLPYEMGLVKNQYVARTFIQPTQELREQGVRVKLSAVKDIVDGKNIILVDDSIVRGTTIRRIVKMLK-DSGANKVHVRIA 385 Staphylococcus aure...
15674270 308 GLPNEMGLVKNQYTQRTFIQPTQELREQGVRMKLSAVSGVVKGKRVVMIDDSIVRGTTSRRIVGLLR-EAGASEVHVAIA 386 Streptococcus pyoge...
15897546 290 HIPLEEPLVRTISSVRSFIMPTQDKRNEVLEEKFGVVADAVRGKRIVLIDDSIVRGNTMKRIITMLR-KAGAKEIHVRIG 368 Sulfolobus solfatar...
15644003 287 GIPLDIGLMRNRYVGRSFIMPVD--REKIVKKKLVPIEDVVSGKRVVVIDDSIVRGTTMGIIVKILR-EAGAKEVHVGIH 363 Thermotoga maritima
16800946 306 GLPYELGLIKNRYVARTFIQPSQELREQGVRMKLSAVRGVVEGKRVVMIDDSIVRGTTSKRIVQLLR-EAGAAEVHVRIA 384 Listeria innocua
6647716  438 SPPVKWPCFYGIDFPSPAELIANVVAdeeemLEAVRQGIGADTLGYISLRGMIAASEQPA-----SRLCYACFDGRYPIE 512 Mycobacterium leprae
21759385 376 SPPIRYPCYMGIDIPTRHELIAAWRS-----IEDIRKEIGADSLAYLSIEGLKRAVGTKN-------LCMACLTGEYPEW 443 Pyrococcus abyssi
18311787 316 APPLRSQCPYGVKMPPESHMIFNHLD-----LKTATVALELDSFFHLDVEEFEKTVGMS--------VCTRCFVRP---- 378 Pyrobaculum aerophilum
18311794 342 SPPVKWPCFFGMDFQTRRELVAHKRD-----VEAIRAYIGADSLIYLPLEKFRQILG---------SACYGCFTGEYPVQ 407 Pyrobaculum aerophilum
6647708  376 SPPIRYPCYMGIDIPTRHELIAAWKS-----IEEIKKEIGADSLAYLSVEGLKRAIGTDK-------LCMACLTGNYPEW 443 Pyrococcus horikoshii
15926656 386 SPEFMFPSFYGIDVSTTAELISAS-Ks----PEEIKDYIGADSLAYLSVDGLIESIGLDYda-pySGLCVESFTGDYPAG 459 Staphylococcus aure...
15674270 387 SPELKYPCFYGIDIQTRRELISAN-Hs----VDEVCDIIGADSLTYLSLDGLIESIGLETka-pnGGLCVAYFDGHYPTP 460 Streptococcus pyoge...
15897546 369 SPMIKYPCYMGIDFPKREELIAHNKS-----EKEIGNELNADSIEFLSVEEMLQGIGRR-------DLCNACFSGIYPLK 436 Sulfolobus solfatar...
15644003 364 SPPVRFPCFYGIDTARKKELVAGERA-----VEEVKKIVNADSLFYLSLEGLKRAIGRSE-------LCVACFSGEYLHE 431 Thermotoga maritima
16800946 385 SPPLAYPCFYGIDIQTRNELIASN-Ys----VDEICRIIGADSLEYLSEEGLVDSIGKPYpnepyGGLCMAYFNGDYPTP 459 Listeria innocua
6647716  513 LPSEAMLGKNVIEHML 528 Mycobacterium leprae
21759385 444 AFNF------------ 447 Pyrococcus abyssi
18311787     ----------------     Pyrobaculum aerophilum
18311794 408 INVEEAEVSTRGA--- 420 Pyrobaculum aerophilum
6647708  444 AFDFKV---------- 449 Pyrococcus horikoshii
15926656 460 LYDYEANYKAHLSHRQ 475 Staphylococcus aureus subsp. aureus N315
15674270 461 LYDYEEEYLRSLEEKT 476 Streptococcus pyogenes M1 GAS
15897546 437 FNYNSTELERIFGK-- 450 Sulfolobus solfataricus
15644003     ----------------     Thermotoga maritima
16800946 460 LYDYEAEYLASLEAEK 475 Listeria innocua
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