3RMU,1JC5


Conserved Protein Domain Family
metmalonyl_epim
?
TIGR03081: metmalonyl_epim 
Click on image for an interactive view with Cn3D
methylmalonyl-CoA epimerase
Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 5.1.99.1), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.
Links
?
Statistics
?
PSSM-Id: 213772
Aligned: 13 rows
Threshold Bit Score: 184.065
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3RMU_A         5 RLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLG-N------TKMELLHPLGLDSPIAGFLQKNkAG- 76  human
Q96PE7        47 RLNHVAIAVPDLEKAAAFYKNILGAQVSEAVPLPEHGVSVVFVNLG-N------TKMELLHPLGRDSPIAGFLQKNkAG- 118 human
NP_001018602  46 RLNHVAIAVPDLEKATALYRDVLGAQVSDTVPLPEHGVYTVFVELG-N------TKLELLHPLGEKSPIAGFLQKNkAG- 117 zebrafish
XP_781898     29 KLNHVAIAVPDLEKAASMYRDVLGATVSETVPLPDHGVYTIFIELG-N------TKLELLHPLGDDSPIQGFLDKKpEG- 100 purple sea urchin
WP_010943915   4 KINHIGIAVTSLDAAVPFYRDNLGMAFTGTEEVAEQKVRVAFFQIG-E------TKIELLEPTAEDSPIAKFLEKN-GN- 74  Geobacter sulfu...
AAL57846       9 CIDHVAYACPDADEASKYYQETFGWHELHREENPEQGVVEIMMAPAaKlte-hmTQVQVMAPLNDESTVAKWLAKHnGRa 87  Propionibacteri...
WP_011026418   4 KVDHIGIAVKSIEEARKFYEEVLGLKVTGIEEVKEQKVKTAFIPVG-E------SEIELLESTSEDGPVAKFIEKR-GE- 74  Caldanaerobacte...
1JC5_A         9 CIDHVAYACPDADEASKYYQETFGWHELHREENPEQGVVEIMMAPA-AkltehmTQVQVMAPLNDESTVAKWLAKH-NGr 86  Propionibacteri...
AAK52053       7 RIDHVGIAVKNLEEAIKIWE-GLGFKVEEIEEVPDQKVKVAVIKVG-E------NRIELLEATTEDSPIAKFIEKR-GE- 76  Pyrococcus hori...
WP_010973159   4 RLNHVALAVPDLDAAVSRYR-ALGAQVSEPQALPEHGVTVVFIAAD-N------TKIELLHPLGENSPIAAFLERNpGG- 74  Agrobacterium f...
WP_010879707   4 KIDHVGVAVKSLEEAVKTYE-ALGFGVEEIEEVAEQKVRVAMLPAG-E------SRVELLEATSEDSAIAKFISSR-GE- 73  Archaeoglobus f...
WP_011322341   2 RFDHAGVATDDAEGLAFLYEDLFGCSIAHEERFGE--LKVLFLELE-N------GYFELLEP-QDDGTIASYLDEH-GP- 69  Natronomonas ph...
WP_010902311  11 HVDHVGVATEDAADLGELYTALLGAPVAHEEVF--DGLHTVFLDLGgD------GYVELLEPVDEDTTVGRYLQRT-GG- 80  Halobacterium s...

3RMU_A        77 -GMHHICIEVDNINAAVMDLKKKKIRSLSE-EVKIGAHGKPVIFLHPKDCGGVLVELEQ 133 human
Q96PE7       119 -GMHHICIEVDNINAAVMDLKKKKIRSLSE-EVKIGAHGKPVIFLHPKDCGGVLVELEQ 175 human
NP_001018602 118 -GMHHICIEVDDINAAIVDLKEKKIRLLSP-EPRIGAHGKPVMFLHPKDCDGVLVEIEQ 174 zebrafish
XP_781898    101 -GMHHICIEVDNIEEAVKTVKENNIRPLGK-KPRIGAHGKPVMFLHPKDCGGVLIELEE 157 purple sea urchin
WP_010943915  75 -GIHHIAYEVDDIEAAIAKLVADGARMIDS-SPRNGAHGARIAFVHPKSSGGVLTELCQ 131 Geobacter sulfurreducens
AAL57846      88 -GLHHMAWRVDDIDAVSATLRERGVQLLYD-EPKLGTGGNRINFMHPKSGKGVLIELTQ 144 Propionibacterium freudenreichii sub...
WP_011026418  75 -GIHHIALQVDDIEKALEELKGKGVKLIDE-VPRYGAGGAKIAFVHPKSANGVLLELCE 131 Caldanaerobacter subterraneus
1JC5_A        87 aGLHHMAWRVDDIDAVSATLRERGVQLLYD-EPKLGTGGNRINFMHPKSGKGVLIELTQ 144 Propionibacterium freudenreichii sub...
AAK52053      77 -GIHHLAIRVENIESKLEELKQKGYKLIDE-KPRVGAGGAKIAFIHPKSVTGVLLELCE 133 Pyrococcus horikoshii
WP_010973159  75 -GTHHLCFEVPDILVARDDLLKKGVRILGDgEPKIGAHGNPVLFLHPKDMGGVLYELEQ 132 Agrobacterium fabrum
WP_010879707  74 -GIHHIAVNVENIEEALNKAKEAGLRLIDE-KPRVGAGGKKVAFVHPKSTHGVLLEFVE 130 Archaeoglobus fulgidus
WP_011322341  70 -GLHHIALETTDINAALETATDLGVECIDE-APRQGAWGHQVAFLHPKSTGGVLIEYVE 126 Natronomonas pharaonis
WP_010902311  81 -GIHHVAFATDDIEAALETARDAGVDRIDE-EPRAGAWGHDVAFLHPKDTGGALIEFVE 137 Halobacterium salinarum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap