Conserved Protein Domain Family
HDAC6-dom1
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cd11682: HDAC6-dom1 
Histone deacetylase 6, domain 1
Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).
Links
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Statistics
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PSSM-Id: 212545
Aligned: 5 rows
Threshold Bit Score: 655.383
Created: 21-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeZn binding site
Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q9UBN7         99 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQaRFAEKEELMLVHSLEYIDLMETTQYMNEGELRvLADTYDSVYLHP 178  human
XP_001493915   99 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQaRFAEKEELMLVHSLEYIDLMETTQYMNERELRiLADTYDSVYLHP 178  horse
NP_001080486   94 CLWDENFPECPGRIWAVRDKMAEYGLAERCVAVPaREASEEEILLIHSPQYVALMRSTQKMTMDELRaLSDRYDSVYLHP 173  African clawe...
XP_003216905  136 CPWDESFPECPERLVAIRDKLLQCGLLERCVPVLaREISEEEILLAHSPEYLALMKSTETMSKAELKsLSDTFDSVYLHP 215  green anole
XP_693858      76 CLWDASHPECPARVSTVMEMLETEGLLGRCVQVEaRAVTEDELLLVHTKEYVELMKSTQNMTEEELKtLAEKYDSVYLHP 155  zebrafish

Feature 1                                             ##       ##                           # #   
Q9UBN7        179 NSYSCACLASGSVLRLVDAVlgaeIRNGMAIIRPPGHHAQHslMDGYCMFNHVAVAARYAqqkhrirRVLIVDWDVHHGQ 258  human
XP_001493915  179 NSYTCACLASGSVLRLVDAVlgaeIRNGMAIIRPPGHHAQHslMDGYCMFNHVAVAARYAqqkheiqRILIVDWDVHHGQ 258  horse
NP_001080486  174 TSFTCASLAVGSVLQLVDRVqhgeIRNGLAVVRPPGHHAHTdqMNGYCMFNQLAIAARYAqltygakRVLIVDWDVHHGQ 253  African clawe...
XP_003216905  216 NSYHCACLAAGSVLQVVEKVwsgeLCNGLAVVRPPGHHAQHdkMDGYCMFNNVGIAAQYArqklgvdRVLIVDWDVHHGQ 295  green anole
XP_693858     156 GFFSSACLSVGSVLQLVDKVmtsqLRNGFSINRPPGHHAQAdkMNGFCMFNNLAIAARYAqkrhrvqRVLIVDWDVHHGQ 235  zebrafish

Feature 1                                                                                         
Q9UBN7        259 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTtGFGQGQGYTINVPWNQVGMrDADYIAAFLHVLLPVALEFQPQL 338  human
XP_001493915  259 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASDWSTiGFGQGRGYTINVPWNQVGMrDADYIAAFLHILLPVALEFQPQL 338  horse
NP_001080486  254 GTQFIFESDPSVLYFSVHRYDNGGFWPHLKESASSAvGKERGERFNVNVAWNKTRMsDADYIHVFLNVLLPVAYEFQPHL 333  African clawe...
XP_003216905  296 GTQYLFEDNPSVCYFSIHRYEGGNFWPHLPESDSHAvGRGRGEGYNINVPWDQIGMgDADYLAAFLHILMPVALEFQPQL 375  green anole
XP_693858     236 GIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSvGSGAGQGYNINLPWNKVGMeSGDYITAFQQLLLPVAYEFQPQL 315  zebrafish

Feature 1                #                                     #                                  
Q9UBN7        339 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYnlrALAEGVSASLHTLLGDPCPmlespgAPCR 418  human
XP_001493915  339 VLVAAGFDALQGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYnlrSLAEGVSASLHTLLGDPCPmlespgAPCL 418  horse
NP_001080486  334 VLVAAGFDSVVGDPKGEMSATPACFSHLTHLLMSLAQGRLILSLEGGYnqrSLAEGACASLKALLGDPCPrltlpsAPCQ 413  African clawe...
XP_003216905  376 VLVAAGFDSVIGDPKGEMATTPGCFAHLAHLLMPLSGGKLVLSLEGGYnlqSLAEGTCTVLKALLGDPCPlldsplAPCR 455  green anole
XP_693858     316 VLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYnlqSTAEGVCASMRSLLGDPCPhlpssgAPCE 395  zebrafish

Feature 1                          
Q9UBN7        419 SAQASVSCALEALEPFW 435  human
XP_001493915  419 SAKASLSCTLEALEPFW 435  horse
NP_001080486  414 SALDSMSDTISAHCSLW 430  African clawed frog
XP_003216905  456 SALHSVSQTIAAHSKFW 472  green anole
XP_693858     396 SALKSISKTISDLYPFW 412  zebrafish

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