1NLT,2CTT,1EXK


Conserved Protein Domain Family
DnaJ_zf
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cd10719: DnaJ_zf 
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Zinc finger domain of DnaJ and HSP40
Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.
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Statistics
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PSSM-Id: 199908
Aligned: 373 rows
Threshold Bit Score: 45.3243
Created: 21-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding sites [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two zinc ions are coordinated by two structural motifs (each of which comprises two sequence motifs CxxCxGxG); the second structural motif/zinc binding site interrupts the first instance as an insert.
  • Structure:1NLT: The yeast Hsp40 protein Ydj1 binds two zinc ions.
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  • Structure:1EXK: Escherichia coli DnaJ binds two zinc ions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #              #  #                      #  #            #  #    
1NLT_A        41 CKECEGRGgk--kGAVKKCTSCNGQGIKfvtrqmgpmiqrfqTECDVCHGTGDIIdpkdRCKSCNGKK 106 baker's yeast
YP_004369231 143 CPGCKGSGy---eYAGQVCPACGGRGVVekkvd----nvrmlINCAACQGTGRTGq--qSCRRCGGRG 201 Desulfobacca acetoxidans DS...
YP_285672    113 CPTCEGSGea-gmSRTRFCDACHGSGRIhdaq-------rklVRCDACDGRGLFRe--rICPDCGGSG 170 Dechloromonas aromatica RCB
EFA76295     267 CGHCLGTGsstkqREFTTCQRCNGNGRVtnf--------llaFACDVCNGQGVILk--nTCNYCHGDG 324 Polysphondylium pallidum PN500
EDK37837     178 CKHCHGIGg----ANPKSCPSCEGSGRVmmtmankfcrsqevSSCRACDGTGTVVspndQCPHCNRGY 241 Pichia guilliermondii ATCC ...
EEE65339     386 CDSCDGRGyl-anAKMYVCPSCRGAGRVsin--------pftSICTSCRGFGKVIk--dYCLTCKGSG 442 Japanese rice
YP_158994    120 CGACGGSGee-vlRHTRLCATCHGSGRVrdg--------rslTACADCAGRGYLSr--qACGACHGSG 176 Azoarcus sp. EbN1
YP_003168759 114 CRRCCGSGkl-qhDHLVPCPRCSGCGRVsrgr-------ggtSRCTSCAGRGYLRe--tDCADCAGSG 171 Candidatus Accumulibacter p...
CBZ32936     157 CPSCHGHGts-sgRPSPVCPQCKGNKTVtkalnfggltayqqCRCDRCEGLGKLPiq-sPCARCGPVY 222 Leishmania donovani BPK282A1
YP_001792203 136 CPDCNGAGy---rVLGGHCPQCHGSGAIrqpmwf--swvgvpAECDACHGGGIARq---ACVACAGSG 195 Leptothrix cholodnii SP-6

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