3CD3


Conserved Protein Domain Family
SH2_Fps_family
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cd10361: SH2_Fps_family 
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Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
The Fps family consists of members Fps/Fes and Fer/Flk/Tyk3. They are cytoplasmic protein-tyrosine kinases implicated in signaling downstream from cytokines, growth factors and immune receptors. Fes/Fps/Fer contains three coiled-coil regions, an SH2 (Src-homology-2) and a TK (tyrosine kinase catalytic) domain signature. Members here include: Fps/Fes, Fer, Kin-31, and In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
Links
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Statistics
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PSSM-Id: 198224
Aligned: 64 rows
Threshold Bit Score: 77.9531
Created: 16-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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phosphotyrosinehydrophobic
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #               #                                                 
3CD3_A      8 KPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQg----------------------------kQEYVLSVLWDg----- 54  human
CAA94372    9 KWLMNQKFYHGYLPREDLPYVLKKKGDFIFRVTErtvg----------------------keqkKDIVLSIAWPtesvam 66  nematode
ADY43573    2 GSEFNLEYYHGALLDEDANKLLEEDGDFLIQSKNepn------------------------htrNKLVLAVKKAg----- 52  pig roundworm
NP_500644  73 KSLQAMPFYHGFLPRDDLGVIIRNEGDYLIRVSEittkke------------------gttgikRDIILSVCSSerggte 134 nematode
EDP29274   21 YDHADMDCWHGMIPDEDTAMLLKNSGDFLMRAVEhd--------------------------rgYKITLSIRWGn----- 69  agent of lymphatic...
ADY45710    2 MSEYSLEYFHGALLDEDADKLLEKDGDFLIQSRSepn------------------------hsrSKLILAVRKGg----- 52  pig roundworm
NP_491620 165 DYITKMPNFHGYICREDAAQILKHPGDWLVRLSVppsndqdkknkaqnlaksvertkghkstmqKVFVISVLCKgkals- 243 nematode
ADY45842   10 AEEYVLQYFHGALPDVDADKLLVHQGDFLIQSRHdan------------------------nsrDRLILAIRKGs----- 60  pig roundworm
EFO21020    2 SGENSLPFFHGALLDDDADKMLELNGDFLLQTKFeqs------------------------kkkNKLVLAIKHGh----- 52  Loa loa
AAF98610   11 DEDRTLPYFHGALMNIDADQLLVNDGDFMVTTRIvad------------------------lnkLQFHLAVRLKk----- 61  nematode

Feature 1                           # #                                   
3CD3_A     55 -------------------lPRHFIIQSLDn--LYRLEge-gFPSIPLLIDHLLSTQQPL 92  human
CAA94372   67 ---------------idtkdIKNYLIERSAn--SVWLDlkisFHSIDALYNHYRKNELVH 109 nematode
ADY43573   53 -------------------kPRRIDIQRLEn--GFRIMgk-sFANVKTLIDYYQTRNLSV 90  pig roundworm
NP_500644 135 teqtntksdakselnlgerkMRNMVIRRFDg--KFGIKgn-lFPTIEALLANYHVTNALE 191 nematode
EDP29274   70 -------------------eVVNSEIVPGIq-gGYKFQgk-hFCQTKDLIDSYQVTKRPL 108 agent of lymphatic filariasis
ADY45710   53 -------------------kPRRVDIQRLEn--GFRIVgk-sFGDVKSLIEYYQTRTIEM 90  pig roundworm
NP_491620 244 ---------------paksnNRNLVIKTNNg--KFSIDsvhwLVKLKDLFSHYQGTSAVH 286 nematode
ADY45842   61 -------------------rVRRFDIQRCVh--GVRILgk-sFASIQAMVEHYHSKNLET 98  pig roundworm
EFO21020   53 -------------------rTIRIPISRLEk--GYRIFgr-sFQTMNTLIKYYQEHNLEI 90  Loa loa
AAF98610   62 -------------------gIRRYEIKRNQnsaKLGNRs---ASNIGKLIDSLKAETIEI 99  nematode

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