Conserved Protein Domain Family
NIRF_N
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cd01797: NIRF_N (this model, PSSM-Id:176392 is obsolete and has been replaced by 340495)
amino-terminal ubiquitin-like domain of Np95 and NIRF
NIRF_N This CD represents the amino-terminal ubiquitin-like domain of a family of nuclear proteins that includes Np95 and NIRF (Np95/ICBP90-like RING finger) protein. Both Np95 and NIRF have a domain architecture consisting of a ubiquitin-like domain, a PHD finger, a YDG/SRA domain, Rb-binding motifs and a RING finger domain. Both Np95 and NIRF are ubiquitin ligases that ubiquitinate PCNP (PEST-containing nuclear proteins). While Np95 is capable of binding histones, NIRF is involved in cell cycle regulation.
Links
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Statistics
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PSSM-Id: 176392
Aligned: 6 rows
Threshold Bit Score: 151.509
Created: 8-May-2010
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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hydrophobiccharged pocket
Feature 1:hydrophobic patch
Evidence:
  • Comment:surface patch shown to be essential for proteolytic targeting in some ubiquitins
  • Citation:PMID 9857029
  • Citation:PMID 8570649
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   ####                               
AAH28397     1 MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQL-------------------------ENG 55   human
BAC81739     1 MWIQVRTIDGSQTRTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQL-------------------------ENG 55   house mouse
AAF28469     1 MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQM-------------------------EDG 55   human
AAH72079     1 MWIQVRTMDGRDTRRIDSLSKLTKVDDLRDRIQQLFGVALESQRLFYRGKQM-------------------------ENG 55   African clawed frog
CAF99207     1 MWIQVRTIDGKETRTVEDLSRLTKIESLRLKIQDIFNVSPQQQRLFYRGKQVkplrrpnevcgmdkehakrqrdrqmEDG 80   Tetraodon nigrov...
NP_998242    1 MWIQVRTMDGKETHRVDSLSKLTKVDELRVKIAELFNVEPERQRLFYRGKQM-------------------------EDG 55   zebrafish

Feature 1                      ##     
AAH28397    56 YTLFDYDVGLNDIIQLLVRPDPD 78   human
BAC81739    56 YTLFDYDVGLNDIIQLLVRPDSS 78   house mouse
AAF28469    56 HTLFDYEVRLNDTIQLLVRQSLV 78   human
AAH72079    56 HTLFDYSVGLNDIVQLLVRQIPD 78   African clawed frog
CAF99207    81 QTLFDYNVGLNDIIQLLIRSQTE 103  Tetraodon nigroviridis
NP_998242   56 HTIFDYNVGLNDIVQLLVRQAVA 78   zebrafish

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